AI and precision oncology in clinical cancer genomics: From prevention to targeted cancer therapies-an outcomes based patient care

Dlamini, Zodwa; Skepu, Amanda; Kim, Namkug; Mkhabele, Mahlori; Khanyile, Richard; Molefi, Thulo; Mbatha, Sikhumbuzo; Damane, Botle Precious; Mulaudzi, Thanyani Victor; Mabongo, Mzubanzi; Bida, Meshack; Kgoebane-Maseko, Minah; Mathabe, Kgomotso; Lockhat, Zarina I.; Kgokolo, Mahlatste; Chauke-Malinga, Nkhensani; Ramagaga, Serwalo; Hull, Rodney

doi:10.1016/j.imu.2022.100965

Cited by 22 publications

(19 citation statements)

References 93 publications

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“…Technology is a tool that, under the guidance of the knowledge and expertise of our Center professionals, focuses on meeting those needs: treating the patient and taking care of the person. Thanks to the use of artificial intelligence (AI) and advanced medical technologies, it is increasingly possible to realize personalized and tailored cancer care pathways ( 24 , 25 ). In our context, we are investigating the combination of art and technology to include patients' emotional and relational experiences.…”

Section: Introduction: Integration Of Art and Technology In Personali...mentioning

confidence: 99%

Integration of art and technology in personalized radiation oncology care: Experiences, evidence, and perspectives

Casà

Dinapoli

Marconi

et al. 2023

Front. Public Health

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Cancer diagnoses expose patients to traumatic stress, sudden changes in daily life, changes in the body and autonomy, with even long-term consequences, and in some cases, to come to terms with the end-of-life. Furthermore, rising survival rates underline that the need for interventions for emotional wellbeing is in growing demand by patients and survivors. Cancer patients frequently have compliance problems, difficulties during treatment, stress, or challenges in implementing healthy behaviors. This scenario was highlighted during the COVID-19 emergency. These issues often do not reach the clinical attention of dedicated professionals and could also become a source of stress or burnout for professionals. So, these consequences are evident on individual, interpersonal, and health system levels. Oncology services have increasingly sought to provide value-based health care, considering resources invested, with implications for service delivery and related financing mechanisms. Value-based health care can improve patient outcomes, often revealed by patient outcome measures while seeking balance with economical budgets. The paper aims to show the Gemelli Advanced Radiation Therapy (ART) experience of personalizing the patients' care pathway through interventions based on technologies and art, the personalized approach to cancer patients and their role as “co-stars” in treatment care. The paper describes the vision, experiences, and evidence that have guided clinical choices involving patients and professionals in a co-constructed therapeutic pathway. We will explore this approach by describing: the various initiatives already implemented and prospects, with particular attention to the economic sustainability of the paths proposed to patients; the several pathways of personalized care, both from the patient's and healthcare professional perspective, that put the person's experience at the Gemelli ART Center. The patient's satisfaction with the treatment and economic outcomes have been considered. The experiences and future perspectives described in the manuscript will focus on the value of people's experiences and patient satisfaction indicators, patients, staff, and the healthcare organization.

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Section: Introduction: Integration Of Art and Technology In Personali...mentioning

confidence: 99%

Integration of art and technology in personalized radiation oncology care: Experiences, evidence, and perspectives

Casà

Dinapoli

Marconi

et al. 2023

Front. Public Health

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“…We face big obstacles managing, organizing, and processing the vastness of these data, but also encounter great opportunities as this information will be valuable for a better understanding of patient populations in a more personalized and precise way ( 13 ). AI is a set of informatic algorithms and computing frameworks that are usually used to simulate, enhance, and or even replace human reasoning in the form of decision-making, speech recognition, language understanding, visual perception, and pattern recognition ( 14 ). The final goal of using AI in PO is to accomplish tasks that would normally be performed by human experts in a certain field.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, mutations and genetic alterations can be found in certain genes and non-coding regulatory regions by comparing a cancer genome with a template of healthy DNA. This process of comparing and identifying differences is known as variant calling ( 14 ). The workflow for variant calling is a somewhat bothersome process in which a lot of bias and propensity to error might be found, not to mention high time consumption.…”

Section: Introductionmentioning

confidence: 99%

“…Cancer is a complex etiology, as its molecular characteristics and interactions are too. In the last decades, biomarkers have become a cornerstone for cancer treatment for their many implications: risk assessment, screening, differential diagnosis, classification and cancer typification, response to treatment monitoring, and prognosis in general ( 14 , 31 ). These biomarkers can be identified by several techniques focused on the detection of genomic alterations.…”

Section: Introductionmentioning

confidence: 99%

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Integration of artificial intelligence and precision oncology in Latin America

Sussman

García-Robledo

Ordóñez-Reyes

et al. 2022

Front. Med. Technol.

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Next-generation medicine encompasses different concepts related to healthcare models and technological developments. In Latin America and the Caribbean, healthcare systems are quite different between countries, and cancer control is known to be insufficient and inefficient considering socioeconomically discrepancies. Despite advancements in knowledge about the biology of different oncological diseases, the disease remains a challenge in terms of diagnosis, treatment, and prognosis for clinicians and researchers. With the development of molecular biology, better diagnosis methods, and therapeutic tools in the last years, artificial intelligence (AI) has become important, because it could improve different clinical scenarios: predicting clinically relevant parameters, cancer diagnosis, cancer research, and accelerating the growth of personalized medicine. The incorporation of AI represents an important challenge in terms of diagnosis, treatment, and prognosis for clinicians and researchers in cancer care. Therefore, some studies about AI in Latin America and the Caribbean are being conducted with the aim to improve the performance of AI in those countries. This review introduces AI in cancer care in Latin America and the Caribbean, and the advantages and promising results that it has shown in this socio-demographic context.

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“…Deep learning is the next step that combines advanced computers and special networks; deep learning discovers and develops itself while learning complex patterns hidden in big data. These AI technologies have made rapid advances in the fields of cancer genomic medicine and diagnostic support (Dlamini et al, 2022) and are used in performing gene analysis and image analysis by the automatic acquisition of multimodal learning, multitasking learning, expression learning, and hierarchical features, which are the characteristics of deep learning. Research and development aimed at optimizing cancer treatment and diagnostic systems have been promoted.…”

mentioning

confidence: 99%

Telenursing and artificial intelligence for oncology nursing

Kamei¹

2022

Asia-Pacific Journal of Oncology Nursing

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AI and precision oncology in clinical cancer genomics: From prevention to targeted cancer therapies-an outcomes based patient care

Cited by 22 publications

References 93 publications

Integration of art and technology in personalized radiation oncology care: Experiences, evidence, and perspectives

Integration of art and technology in personalized radiation oncology care: Experiences, evidence, and perspectives

Integration of artificial intelligence and precision oncology in Latin America

Telenursing and artificial intelligence for oncology nursing

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