In the Health 5.0, disease screening and management of pandemics need a mixture of cutting-edge technology with Artificial Intelligence (AI). AI also spreads to the key stages of recognizing threats such as disease, diagnosing with ever - increasing precision and planning actions like response. Healthcare systems can use AI-driven tools to examine large-scale data, detect the early signals of an outbreak and get resources allocated more efficiently. AI also enables pandemic prevention, control and disaster relief by predicting vaccine demand in large-scale vaccination (mass-vaccination), optimizing supplies chains as well identifying populations with greater vulnerability to the virus. While the world battles rising health emergencies, leveraging AI to detect diseases, and manage pandemics is essential for global health security amplifying our response times and reaches while reducing disparities in access to care.