AIDS and chagas' disease with central nervous system tumor-like lesion

Castillo, Marcelo Del; Mendoza, Guillermo; Oviedo, Jorge; Bianco, Raul Pedro Perez; Anselmo, A; Silva, Marcelo

doi:10.1016/0002-9343(90)90544-n

Cited by 118 publications

(75 citation statements)

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“…From these, 13 have already been published (Rocha et al 1994, Ferreira 1996. The first case of association between Chagas' disease/AIDS was published by Del Castillo et al (1990) reporting the observation of a tumor in the cranial computed tomographic scan of a patient. The first case considered as reactivation of Chagas' disease in a HIV positive patient proceeding from an endemic area was published by Gluckstein et al (1992).…”

Section: Discussionmentioning

confidence: 99%

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Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain

Pacheco

Ferreira

Machado

et al. 1998

Mem. Inst. Oswaldo Cruz

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Section: Discussionmentioning

confidence: 99%

“…+ Corresponding author. Fax: +55-21-590.3495 Received 25 August 1997 Accepted 8 January 1998 been described in immunosuppressed patients, some of them showing fatal central nervous system (CNS) lesions related to the reactivation of the parasite (Del Castillo et al 1990, Ferreira et al 1991, Gluckstein et al 1992, Rocha et al 1994, Ferreira 1996.…”

mentioning

confidence: 99%

Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain

Pacheco

Ferreira

Machado

et al. 1998

Mem. Inst. Oswaldo Cruz

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“…Such factors have had the parasitemia as its main predictor 7,81 . The parasitemia must be identified by direct methods in blood or other organic fluids, always reflecting high intensity.…”

Section: Casesmentioning

confidence: 99%

“…This fact is based on increased survival of Chagas disease patients, urbanization of the population amongst other situations and consequently a higher probability of comorbidities, infectious or not 6 . Therefore, with the emergence of the human immunodeficiency virus (HIV) and the development of acquired immunodeficiency syndrome (AIDS), the co-infection with the Trypanosoma cruzi (T. cruzi) began to be described 7 . As in other infectious diseases, the T. cruzi behaves, potentially, as an opportunist microorganism in subjects with immunosuppression of any nature, among them, any generated by HIV, which is predominant in urban areas 8 .…”

Section: Introductionmentioning

confidence: 99%

Co-infection Trypanosoma cruzi/HIV: systematic review (1980 - 2010)

Almeida

Ramos

Correia

et al. 2011

Rev. Soc. Bras. Med. Trop.

114

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Introduction:The co-infection Trypanosoma cruzi/HIV has been described as a clinical event of great relevance. The objective of this study was to describe clinical and epidemiological aspects published in literature. Methods: It is a systematic review of a descriptive nature from the databases Medline, Lilacs, SciELO, Scopus, from 1980 to 2010. Results: There were 83 articles (2.8 articles/year) with a total of 291 cases. The co-infection was described in 1980 and this situation has become the defining AIDS clinical event in Brazil. This is the country with the highest number of publication (51.8%) followed by Argentina (27.7%). The majority of cases are amongst adult men (65.3%) native or from endemic regions with serological diagnosis in the chronic stage (97.9%) and indeterminate form (50.8%). Both diseases follow the normal course, but in 41% the reactivation of the Chagas disease occurs. The most severe form is the meningoencephalitis, with 100% of mortality without specific and early treatment of the T. cruzi. The medication of choice was the benznidazole on doses and duration normally used for the acute phase. The high parasitemia detected by direct or indirect quantitative methods indicated reactivation and its elevation is the most important predictive factor. The lower survival rate was related to the reactivation of the Chagas disease and the natural complications of both diseases. The role of the antiretroviral treatment on the co-infection cannot yet be defined by the knowledge currently existent. Conclusions: Despite the relevance of this clinical event there are still gaps to be filled.

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“…In regards to the first two patients, they behaved as most of the other patients described in the literature 6,7,12,16,17 with a very poor outcome in spite of specific treatment, and like most of them, died shortly after diagnosis.…”

Section: Discussionmentioning

confidence: 64%