AIDS and Hematopoietic Transplantation: HIV Infection, AIDS, Lymphoma and Gene Therapy

Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS)

“…These two mechanisms are shown in Figure 6.12. As with other gene therapy techniques, delivery of siRNA to specific cells and tissues has been the major challenge in realizing the potential of RNAi [83]. New nanotechnology platforms are tackling this problem by providing nonviral alternatives for effective and safe delivery.…”

“…As discussed above, siRNA are small single-stranded RNA molecules that are complementary to the gene targeted for knockdown [83]. The first study reporting the use of siRNA for intravaginal microbicide delivered siRNA using lipids and protected mice from lethal Herpes simplex virus 2 infection [120].…”