AIDS Effects in Liver and Biliary Tract by using Ultrasound in Sudan

Mahmoud, Mustafa Z.; Abdulla, Alsafi A.; Elgyoum, Ala. M. Abd

doi:10.21608/aeji.2012.15962

Cited by 3 publications

(7 citation statements)

References 12 publications

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“…Different hepatobiliary sonographic abnormalities such as enlarged gallbladder (GB), increased liver echogenicity, hepatomegaly, thickened GB wall, gallbladder sludge and stone were observed in this study which were comparable with those documented by other authors (Obajimi et al (2008); Igbinedion et al (2009); Pawar et al (2013); Mahmoud et al (2012). Some of these abnormal ultrasound findings (enlarged GB, increased liver echogenicity and hepatomegaly) correlated significantly with CD 4 + count (P = 0.001).…”

Section: Discussionsupporting

confidence: 90%

“…This finding is also similar to the report of the Joint United Nations Programme on HIV/AIDS (UNAID), 2010) which documented that the percentage of women living with HIV/AIDS increased from 43% in 1999 to 50% in 2010 and that Sub-Sahara African women comprised 59% of adults infected with HIV (Global Fact sheet, 2012). The sex ratio in this study was however at variance with the study documented in Sudan by Mahmoud et al (2012) which showed a higher male preponderance of 66%. The finding of female preponderance in this study could be due to the fact that females" genital anatomy places them more at risk for sexually transmitted infections, compared to men (Center for Disease Control and Prevention Fact sheet, 2017).…”

Section: Discussioncontrasting

confidence: 88%

“…In this study, the prevalence of abnormal liver enzymes (ALT, AST and ALP) and ultrasound abnormalities (hepatomegaly, increased liver echogenicity, enlarged GB, thickened GB wall, GB sludge and stone) in adult HIV positive patients was 47.3%. This was lower than in earlier reported studies done by Igbinedion et al (2009), Pawar et al (2013) and Mahmoud et al (2012) which recorded 66.6, 96.0 and 93.3% respectively. This low prevalence may be due to the fact that all the patients at the time of conducting this study were already on regular Highly Active Antiretroviral Therapy (HAART).Some patients with normal liver enzymes had abnormal ultrasound findings and vice versa; an average of 46.3% of the patients had various grades of liver enzymes abnormalities.This was not in agreement with a study done by Savita et al 2015 in India which documented a higher (63%) abnormal liver function tests (LFT).…”

Section: Discussioncontrasting

confidence: 67%

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Correlation of hepatobiliary ultrasonographic findings with cd4cell count and liver enzymes in adult hiv/aids patients in Jos

Angbalaga¹,

Ani²,

Eze³

et al. 2018

J. AIDS HIV Res.

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Hepatobiliary diseases occur commonly in patients with Human immunodeficiency virus (HIV) infection and are now the commonest cause of death in HIV positive patients on antiretroviral therapy (ART) in western countries. The hepatobiliary manifestations of AIDS are related to the levels of CD 4 + count as well as liver enzymes. Abdominal ultrasound examination is easy to perform, non-invasive, inexpensive, readily available and provides valuable information about hepatobiliary findings in AIDS. The study was to evaluate hepatobiliary sonographic findings in HIV/AIDS adult patients and correlate with their CD 4 + count and abnormal liver enzymes (ALP, ALT and AST) in Jos, Plateau State, Nigeria. A cross-sectional study of hepatobiliary ultrasound findings of 410 adult patients with HIV/AIDS was carried out over a period of six months. Two hundred and sixteen (52.7%) of the patients had normal hepatobiliary ultrasound findings while 194 (47.3%) patients had various abnormalities. The common abnormalities seen include enlarged gallbladder in 33.5%, increased liver parenchymal echogenicity in 26.3%, hepatomegaly in 23.7%, and thickened gallbladder wall in 7.8% patients. Other findings included gallbladder sludge and gall stone in 6.6 and 2.1% respectively. These findings correlated significantly with the patients' CD 4 + count and liver enzymes (ALT, AST and ALP) with p value < 0.05 in both. Ultrasonography as a baseline imaging modality in HIV/AIDS patients, together with CD 4 + count and liver enzymes are useful in the assessment of the disease state, monitoring of therapy and management of these patients.

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 88%

Section: Discussioncontrasting

confidence: 67%

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Correlation of hepatobiliary ultrasonographic findings with cd4cell count and liver enzymes in adult hiv/aids patients in Jos

Angbalaga¹,

Ani²,

Eze³

et al. 2018

J. AIDS HIV Res.

View full text Add to dashboard Cite

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“…In line with this, Mahmoud et al . [ 6 ] and Bhabhor et al . [ 3 ] reported that males were most prone to experience the anomalies.…”

Section: Discussionmentioning

confidence: 99%

“…3 Antiretroviral therapy’s development and widespread use have increased life expectancy and enhanced quality of life, which may be why these abdominal signs are now becoming more common. [ 6 , 7 ] It is well-recognized that HIV/AIDS can affect many organs and cause a wide range of clinical symptoms.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the USG Detection of Abdominal Pathologies in HIV and Aids and its Association with CD4 Counts – An Original Research

Kyasa,

Achuta,

Gupta

et al. 2023

Journal of Pharmacy and Bioallied Sciences

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Introduction: In individuals with acquired immunodeficiency syndrome (HIV/AIDS), abdominal pathologies rank second in frequency only to pulmonary illnesses. An essential imaging method for assessing abdominal diseases is ultrasonography (USG). In this study, abdominal pathologies in HIV/AIDS patients were evaluated using USG, and their relationship to CD4 count was further examined. Materials and Techniques: 400 HIV+ subjects with aberrant abdominal USG participated in the current investigation. The subjects were assessed and graded as per the CD4 counts. Later the comparisons were drawn between the USG, and its relationship to CD4 count using SPSS 16.0 software, and all data were examined using appropriate statistical tools. Results: Men were over 60% of the 400 subjects. The average age of these subjects was 35.6 years; the range for this age group was 6 to 63 years. Spleen involvement was found on ultrasonographic examination in 45.1% of subjects, while liver and lymph node involvement was seen in 43.6% of subjects. Substantial correlations between CD4 counts and findings such as periportal & mesenteric lymphadenopathy, localized pancreatic lesion, splenic microabscess, splenomegaly, and hepatomegaly were found. One percent of individuals had lymphoma, which affected the retroperitoneal lymph nodes, pancreas, and liver. Conclusion: Present research demonstrates the significance of abdominal ultrasonographic examination in HIV+ patients. CD4 counts have a big impact on how an HIV/AIDS patient’s differential diagnosis is determined. The interpretation of USG results in relation to CD4 levels may aid in accurate diagnosis.

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Sonographic detection of abdominal pathologies in human immunodeficiency virus/acquired immunodeficiency syndrome patients and its correlation with CD4 counts – A prospective analysis

Mankeshwar

Sharma

2020

IJMS

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Objectives: Abdominal pathologies are the second most common after pulmonary diseases in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients. Ultrasonography (USG) is a vital imaging technique for the evaluation of abdominal pathologies. This study was aimed at evaluating the abdominal pathologies using USG in HIV/AIDS and further analysis of its correlation with CD4 count. Material and Methods: The present study was carried out on 392 HIV-positive patients with abnormal abdominal sonographic findings. All data were analyzed by Chi-square test and one-way analysis of variance using SPSS 16.0 software. Results: Of these 392 patients, 66.3% were males, the mean age was 35.7 years, (range 7–64 years) and most of them were in 4th decade. On ultrasonographic evaluation, spleen was involved in 45.2% patients and liver as well as lymph nodes each was involved in 43.6% patients. Other cases displayed ascites and bowel thickening in 5.3% and 3.8% patients, respectively. Less involvement of kidney (2.3%), pancreas (1.5%), and biliary system (1.3%) was observed. In addition, pathologies such as hepatomegaly, splenomegaly, splenic microabscess, focal pancreatic lesion, mesenteric, and periportal lymphadenopathy showed significant correlation with CD4 counts. Lymphoma was found in 1% of patients, involving liver, pancreas, and retroperitoneal lymph nodes. Conclusion: Our study highlights the clinical utility of abdominal USG in HIV/AIDS patients. CD4 counts largely affect the differential diagnosis in HIV/AIDS patients. USG findings interpreted in the context of CD4 count may help in guiding the exact diagnosis.

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AIDS Effects in Liver and Biliary Tract by using Ultrasound in Sudan

Abstract: Liver enlargement and gall bladder wall thickening are common effects develop due to AIDS infection in population at Khartoum state, Sudan.

Cited by 3 publications

References 12 publications

Correlation of hepatobiliary ultrasonographic findings with cd4cell count and liver enzymes in adult hiv/aids patients in Jos

Correlation of hepatobiliary ultrasonographic findings with cd4cell count and liver enzymes in adult hiv/aids patients in Jos

Assessment of the USG Detection of Abdominal Pathologies in HIV and Aids and its Association with CD4 Counts – An Original Research

Sonographic detection of abdominal pathologies in human immunodeficiency virus/acquired immunodeficiency syndrome patients and its correlation with CD4 counts – A prospective analysis

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