AIDS-related BL and CD4 count: a clue?

Smith, Sonali M.

doi:10.1182/blood-2010-09-306407

Cited by 7 publications

(6 citation statements)

References 11 publications

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“…Studies have shown that there are multimodal peaks of occurrence of BL in different age groups. 22,24,25 Genetic variations in different age groups have been reported in some studies. 25,39 Chromosomal variations on chromosome 13 and 22 were found to be associated with poor survival in children while only chromosome 17 was associated with poor survival in adults.…”

Section: Cancer Epidemiologymentioning

confidence: 99%

“…22,23 Some studies have suggested that the different peaks have differences in etiology or clinical characteristics/presentation. [24][25][26] For example, Luciano et al 27 found that survival significantly improved in cases treated from 2002 to 2008 compared to cases treated from 1973 to 2001, and attributed the improvement to improved chemotherapy (with Rituximab) and advances in HIV/AIDS treatment. In addition, they found that children have better survival compared to adult and elderly populations.…”

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confidence: 99%

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Survival predictors of Burkitt's lymphoma in children, adults and elderly in the United States during 2000–2013

Mukhtar

Boffetta

Risch

et al. 2017

Intl Journal of Cancer

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Burkitt's Lymphoma (BL) has three peaks of occurrence, in children, adults and elderly, at 10, 40 and 70 years respectively. To the best of our knowledge, no study has been conducted to assess predictors of survival in the three age groups. We hypothesized that survival predictors may differ by age group. We, therefore, sought to determine survival predictors for BL in these three groups: children (<15 years of age), adults (40-70 years of age) and elderly (>70 years of age). Using the Surveillance, Epidemiology, and End Results (SEER) database covering the years 2000-2013, we identified 797 children, 1,994 adults and 757 elderly patients newly diagnosed with BL. We used adjusted Cox proportional hazards regression models to determine prognostic factors for survival for each age group. Five-year relative survival in BL for children, adults and elderly were 90.4, 47.8 and 28.9%, respectively. Having at least Stage II disease and multiple primaries were associated with higher mortality in the elderly group. In adults, multiple primaries, Stage III or IV disease, African American race and bone marrow primary were associated with increased mortality whereas Stage IV disease and multiple primaries were associated with worse outcome in children. These findings demonstrate commonalities and differences in predictors of survival that may have implications for management of BL patients.

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Section: Cancer Epidemiologymentioning

confidence: 99%

mentioning

confidence: 99%

Survival predictors of Burkitt's lymphoma in children, adults and elderly in the United States during 2000–2013

Mukhtar

Boffetta

Risch

et al. 2017

Intl Journal of Cancer

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“…Nodal involvement is more common in adults, as is bulky disease. 60 BL associated with HIV occurs in patients with relatively high CD4 T-cell counts, greater than 50/ μ l, 61 and there is frequent lymph node, gastrointestinal tract and bone marrow localization. Despite this clinical diversity endemic, sporadic and HIV-related BL have similar pathologic features and almost identical miRNA profiles.…”

Section: Burkitt Lymphomamentioning

confidence: 99%

Aggressive B-cell lymphomas: how many categories do we need?

Said

2013

Modern Pathology

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Aggressive B-cell lymphomas are diverse group of neoplasms that arise at different stages of B-cell development and by various mechanisms of neoplastic transformation. The aggressive B-cell lymphomas include many types, subtypes and variants of diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), mantle cell lymphoma and its blastoid variant, and B lymphoblastic lymphoma. Differences in histology, cytogenetic and molecular abnormalities, as well as the relationship with the tumor microenvironment, help define characteristic signatures for these neoplasms, and in turn dictate potential therapeutic targets. Rather than survey the entire spectrum of aggressive B-cell lymphomas, this report aims to identify and characterize important clinically aggressive subtypes of DLBCL, and explore the relationship of DLBCL to BL and the gray zone between them (B-cell lymphoma unclassifiable with features intermediate between DLBCL and BL).

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“…However, trimodal patterns were noted in AIDS-related BL in the U.S. using data from the HIV/AIDS Cancer Match Study (9). Multimodal peaks of BL suggested that BL diagnosed at different ages may have different etiology and/or biology(10). This is reminiscent of Hodgkin lymphoma, whose multimodal peaks are considered clues to different etiology and/or biology (11, 12).…”

Section: Introductionmentioning

confidence: 99%

Pediatric, elderly, and emerging adult‐onset peaks in Burkitt's lymphoma incidence diagnosed in four continents, excluding Africa

et al. 2012

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Burkitt's lymphoma (BL) in the general population and immunosuppressed persons with AIDS in the United States was characterized by three age‐specific incidence peaks near 10, 40, and 70 years. We hypothesized that BL from different geographical areas may exhibit pediatric, adult, and elderly age incidence peaks. We investigated this hypothesis using data on 3,403 cases obtained from the International Agency for Research on Cancer (1963–2002). Data from Africa were sparse or incomplete, and thus were excluded. Age‐standardized rates (ASRs) and age‐specific incidence rates were calculated, supplemented with the calculations performed using age–period–cohort (APC) models. The ASR rose 5.3% (95% confidence interval [CI], 5.0–5.6) per year in males and 4.6% (95% CI, 4.5–4.8) in females. The ASR increased gradually in children, steeply in adults and most rapidly in the elderly both in males and in females. Overall, BL male/female ASR ratio was 2.5, but it declined from 3.1 (95% CI, 3.0–3.3) for pediatric BL to 2.3 (95% CI, 2.2–2.4) for adult BL and 1.5 (95% CI, 1.4–1.6) for elderly BL. Age‐specific incidence peaks occurred near 10 and 70 years in all regions and periods. A peak near 40 years of age emerged in the mid‐1990s, particularly in men. Findings using APC models confirmed those based on the standard analyses. Our findings, based on the international BL cases, support our hypothesis that BL is multimodal and that BL peaks at different ages may be clues to differences in the etiology and/or biology of BL at those ages. Am. J. Hematol. 87:573–578, 2012. © 2012 Wiley Periodicals, Inc.

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AIDS-related BL and CD4 count: a clue?

Cited by 7 publications

References 11 publications

Survival predictors of Burkitt's lymphoma in children, adults and elderly in the United States during 2000–2013

Survival predictors of Burkitt's lymphoma in children, adults and elderly in the United States during 2000–2013

Aggressive B-cell lymphomas: how many categories do we need?

Pediatric, elderly, and emerging adult‐onset peaks in Burkitt's lymphoma incidence diagnosed in four continents, excluding Africa

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