AIDS related malignancies in Brazil

Sampaio, Júlio L.; Brites, Carlos; Araújo, Iguaracyra; Bacchi, Carlos E.; Dittmer, Dirk P.; Tanaka, Paula Yurie; Harrington, William J.; Netto, Eduardo Martins

doi:10.1097/cco.0b013e3282c8c8eb

Cited by 8 publications

(3 citation statements)

References 20 publications

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“…Several studies conducted by individual centers in the region have focused on AIDS-defining cancers (ADCs), mostly Kaposi sarcoma and non-Hodgkin lymphoma. [26][27][28][29][30][31] More recently, the Caribbean, Central and South America Network for HIV Research (CCASAnet) studied the frequency of malignancies in their HIV cohort; 82% were ADCs. The most frequent non-ADCs were Hodgkin lymphoma and skin cancers, which tended to occur in individuals who were older than those with ADCs and diagnosed more than 1 year after HIV diagnosis.…”

Section: Non-aids Malignanciesmentioning

confidence: 99%

HIV and Noncommunicable Diseases (NCDs) in Latin America

Crabtree-Ramírez

Rı́o

Grinsztejn

et al. 2014

JAIDS Journal of Acquired Immune Deficiency Syndromes

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The life expectancy of people living with HIV has dramatically improved with the much increased access to antiretroviral therapy. Consequently, a larger number of people living with HIV are living longer and facing the increased burden of noncommunicable diseases (NCDs). NCDs and HIV infection share common epidemiologic and sociodemographic characteristics that influence their outcomes, which may be difficult to address in the relatively weak health systems of the region. Data on the prevalence and interactions of NCDs and HIV in Latin American countries remain very limited, which hinders their governments' ability to make informed decisions about health care policies. Therefore, there is an urgent need to develop a research agenda that will be the basis for an integrated and comprehensive health care approach to HIV and NCD comorbidities in Latin America.

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Section: Non-aids Malignanciesmentioning

confidence: 99%

HIV and Noncommunicable Diseases (NCDs) in Latin America

Crabtree-Ramírez

Rı́o

Grinsztejn

et al. 2014

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…Regarding Hodgkin's lymphomas, some studies have hypothesized that the introduction of ART would be contrarily related to an increase in cases, since this group of lymphomas appears to be associated with more moderate degrees of immunodeficiency. [7,8] There are few studies on AIDS-associated neoplasms in Brazil [9] , and there has been no report on the profile of these patients with lymphoma and their outcome in Pernambuco.…”

Section: Introductionmentioning

confidence: 99%

HIV-related lymphomas in adults served in the public health network

et al. 2019

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Individuals infected with human immunodeficiency virus (HIV) have higher morbidity and mortality due to cancer, which is the third most common cause of death in this group, despite the high effectiveness of antiretroviral therapy (ART). We describe the clinical and laboratory characteristics, initial staging and outcome of HIV-related lymphoma. We included 18 patients in the study, of whom 61.1% were male, mean age 41 years. Nine of the 18 patients (50%) had a diagnosis of HIV infection concurrent with the diagnosis of lymphoma. The most common histological types were diffuse non-Hodgkin B-cell lymphoma, 8 patients (44.4%); and Burkitt lymphoma, 5 (27.8%) cases. The Cotswold revision of the Ann Arbor staging classification in 14 patients (77.7%) was between III and IV. B Symptoms were present in 11 patients (61.1%), bulky mass was observed in 11 cases (61.1%) and had extra-nodal involvement in 8 patients (44.4%). Of the 18 cases analyzed, 8 followed on to second-line treatment, wherein the CODOX-M/IVAC scheme (cyclophosphamide, adriamycin, vincristine, methotrexate/ifosfamide, etoposide, and cytosine arabinoside) was used in 3 of the cases. The second most common scheme was etoposide, doxorubicin, vincristine and cyclophosphamide (EPOCH), used in 2 cases (25%), while in single cases (12.5% each) cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone (CHOEP), ifosfamide, etoposide, and carboplatin (ICE) and dexamethasone, cisplatin, and cytarabine (DHAP) were used. In this series, we observed very high mortality, equivalent to 44.4%, and a complete response in only 11.1%, much lower than that observed by other authors. We found that patients diagnosed with lymphoma associated with HIV had an advanced early clinical staging, and evolved with low response rates to chemotherapy.

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“…Moreover, immunodeficiency in the presence of other risk factors is responsible for the increased risk of NADM, which since 2003 exceeds the annual numbers of AIDS defining cancers in US 7 . However, there have been few reports of cancer and HIV in Brazil 13,14,15,16 . Thus, the aim of this study was to report the prevalence of cancer and its associated factors among HIV-infected individuals attending an AIDS outpatient clinic in Vitória, State of Espírito Santo, Brazil.…”

Section: Introductionmentioning

confidence: 99%

Malignancies in HIV/AIDS patients attending an outpatient clinic in Vitória, State of Espírito Santo, Brazil

Neto

Milanez

Golub

et al. 2012

Rev. Soc. Bras. Med. Trop.

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Introduction: The present study investigated cancer prevalence and associated factors among HIV-infected individuals attending an AIDS outpatient clinic in Vitória, State of Espírito Santo, Brazil. Methods: A sectional study was conducted among HIV infected adults attending an AIDS outpatient clinic in Vitória, State of Espírito Santo, Brazil. Demographic, epidemiological and clinical data were abstracted from medical records, including cancer diagnoses; nadir and current CD4 cell count, HIV viral load, time on antiretroviral treatment (ART), type of ART and smoking status. Results: A total of 730 (91.3%) patients were included in the study. Median age was 44.0 [interquartile range (IQR): 35–50.3] years; median time since HIV diagnosis was 5.5 years (IQR: 2–10); 60% were male; and 59% were white. Thirty (4.1%) cases of cancer were identified of which 16 (53%) were AIDS defining cancers and 14 (47%) were non-AIDS defining malignancies. Patients diagnosed with cancer presented higher chance of being tobacco users [OR 2.2 (95% CI: 1.04–6.24)]; having nadir CD4 ≤200 cells/mm3 [OR 3.0 (95% CI: 1.19–7.81)] and higher lethality [OR 13,3 (95% CI: 4,57–38,72)]. Conclusions: These results corroborate the importance of screening for and prevention of non-AIDS defining cancers focus in HIV-infected population, as these cancers presented with similar frequency as AIDS defining cancers.

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AIDS related malignancies in Brazil

Cited by 8 publications

References 20 publications

HIV and Noncommunicable Diseases (NCDs) in Latin America

HIV and Noncommunicable Diseases (NCDs) in Latin America

HIV-related lymphomas in adults served in the public health network

Malignancies in HIV/AIDS patients attending an outpatient clinic in Vitória, State of Espírito Santo, Brazil

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