AIDS‐related non‐Hodgkin's lymphomas

Krause, John R.

doi:10.1002/jemt.20230

Cited by 18 publications

(10 citation statements)

References 55 publications

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“…Since the introduction of the highly active antiretroviral therapy, the incidence of lymphoma in AIDS patients has decreased significantly [110]. Most HIV-associated lymphoproliferative disorders are highly aggressive and of a B-cell origin [111,112]. Hodgkin lymphoma is reported to have an 8-fold increased incidence in HIV-positive individuals [113].…”

Section: Ebv and Hiv-related Lymphoproliferative Disordersmentioning

confidence: 99%

“…Primary CNS lymphomas constitute approximately 20% to 25% of all HIV-related lymphomas and have a thousandfold increased incidence in AIDS patients, although the incidence has decreased significantly since the introduction of highly active antiretroviral therapy [111,115,120]. These tumors have a tendency to occur late in the course of HIV infection and show EBV association in virtually 100% of the cases [121].…”

Section: Ebv and Hiv-related Lymphoproliferative Disordersmentioning

confidence: 99%

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Epstein-Barr virus–associated lymphoproliferative disorders

2007

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Section: Ebv and Hiv-related Lymphoproliferative Disordersmentioning

confidence: 99%

Section: Ebv and Hiv-related Lymphoproliferative Disordersmentioning

confidence: 99%

Epstein-Barr virus–associated lymphoproliferative disorders

2007

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“…Other histological types such as Burkitt lymphoma (BL), Hodgkin lymphoma, and T/null cell anaplastic large cell lymphoma are also overrepresented among ARLs. [1][2][3][4] The pathogenesis of ARL is poorly understood. It has been postulated that cell proliferation occurring in the setting of severe immunosuppression and driven by chronic antigenemia resulting at first in the polyclonal and ultimately in the monoclonal lymphoproliferation plays a key role in lymphomagenesis in HIV patients.…”

mentioning

confidence: 99%

“…In addition, cell infection by the EpsteinBarr virus (EBV) and human herpesvirus 8 (HHV8) most likely contributes to the malignant cell phenotype in some subtypes of ARL, with the association of primary effusion lymphoma with HHV8 being essentially universal. [1][2][3][4] Regardless of the histological type of ARL, chemotherapy is typically ineffective and new treatment approaches are clearly needed to combat this group of lymphomas. In addition to ARL, HIV patients develop a benign reactive lymphadenopathy, particularly early after the infection as an overall ineffective response to the virus.…”

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confidence: 99%

Activation of mTORC1 Signaling Pathway in AIDS-Related Lymphomas

El-Salem

Raghunath

Marzec

et al. 2009

The American Journal of Pathology

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Using immunohistochemistry with antibodies against the phosphoserine residues in both S6rp and 4E binding protein 1, we identified the activation of the mammalian target of rapamycin (mTORC)1 pathway in 29 cases of AIDS-related lymphoma. These cases represented a diverse spectrum of histological types of nonHodgkin lymphoma (24 cases) and classic Hodgkin lymphoma (five cases). mTORC1 was also activated in the hyperplastic but not involuted follicles of HIV-associated lymphadenopathy in eight cases, supporting the notion that mTORC1 activation is a common feature of transformed lymphocytes irrespective of either their reactive or malignant phenotype. We also found that in B-cell lines that represent diffuse large B-cell lymphoma, Burkitt lymphoma, Epstein-Barr virus-infected lymphocytes, and human herpesvirus 8-positive primary effusion lymphoma, inhibitors of Syk, MEK, and, seemingly , phosphoinositide 3 kinases suppressed mTORC1 activation , in particular when these inhibitors were used in combination. These findings indicate that AIDS-related lymphoma and other histologically similar types of lymphomas that are derived from transformed B lymphocytes may display clinical responses to inhibitors that directly target mTORC1 or , possibly , upstream activators of the mTORC1 pathway.

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“…After Kaposi sarcoma, non-Hodgkin's lymphoma (NHL) is the second most common malignancy in patients with AIDS 7 8. NHL occurs in patients with AIDS in a much higher prevalence than the non-AIDS population 7 8.…”

Section: Discussionmentioning

confidence: 99%

Diffuse large B cell lymphoma of the eyelid in a patient with AIDS

Hwang

Melson

Grossniklaus

2010

British Journal of Ophthalmology

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A 49-year-old man was evaluated for rapidly enlarging left lower eyelid and left neck masses. Biopsies of the masses showed diffuse large B-cell lymphoma (DLBCL). He tested positive for Human Immunodeficiency Virus (HIV). The patient was treated with chemotherapy and antiretroviral therapy, and the masses reduced in size. KeywordsAcquired Immunodeficiency Syndrome; Diffuse Large B-Cell Lymphoma; Rituximab; c-Myc Gene; Eyelids; Orbit Case ReportA 49-year-old man was evaluated for left jaw pain and swelling. He had a left neck mass that he noticed a week prior to presentation, which had rapidly enlarged and become painful. The patient also had a two-month history of an enlarging left lower eyelid mass (Figure 1). The patient denied fevers, chills, or weight loss, but admitted to having night sweats. He had no recent history of oral abscesses or dental procedures and denied having any ocular pain, dysphagia, dypsnea, or difficulty breathing. He denied having a history of Human Immunodeficiency Virus (HIV).Computed tomography (CT) of the head and neck revealed a large soft tissue mass in the left lower eyelid, measuring 5×4cm. The mass extended into the superomedial orbit, compressing and displacing the globe laterally. Additionally, the CT revealed a 5×5cm neck mass with central necrosis as well as enlarged submental and bilateral jugular lymph nodes. The findings were suspicious for an abscess, and the patient underwent biopsy with incision and drainage of the neck mass and biopsy of the left lower eyelid mass. Cultures from the neck mass were negative. The patient gave permission for a laboratory testing for HIV, and it showed that he was positive with a CD4 count of 187/mm 3 and a viral load of 131,000 copies/mL. The Corresponding Author has the right to grant on behalf of all authors and does grant on behalf of all authors, an exclusive licence (or non exclusive for government employees) on a worldwide basis to the BMJ Publishing Group Ltd and its licencees, to permit this article (if accepted) to be published in BJO and any other BMJ Group products and to exploit all subsidiary rights, as set out in our licence (http://bjo.bmjjournals.com//ifora/licence.pdf). Microscopic examination of the eyelid specimen was performed (Figure 2A,B). Special stains for fungi and bacteria including acid-fast bacilli were negative. Immunohistochemical stains were positive for CD45, CD68, and Ki-67 in many cells with Ki-67 cell fraction of 50% ( Figure 2D), CD20 in the small round cells ( Figure 2C), and CD3 in scattered cells, but negative for Human Herpes Virus 8 (HHV8), Epstein-Barr Virus (EBV), and CD30, which excluded the possibility of a CD30+ lymphoproliferative lesion. Fluorescence in situ hybridization on formalin-fixed tissue showed no rearrangement involving the c-MYC gene. The histopathologic findings in the neck mass specimen were similar to those in the eyelid mass. (The neck mass was actually an enlarged lymph node in the neck). Taken together, both were classified as diffuse large B-cell lymphoma (DLBCL). ...

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AIDS‐related non‐Hodgkin's lymphomas

Cited by 18 publications

References 55 publications

Epstein-Barr virus–associated lymphoproliferative disorders

Epstein-Barr virus–associated lymphoproliferative disorders

Activation of mTORC1 Signaling Pathway in AIDS-Related Lymphomas

Diffuse large B cell lymphoma of the eyelid in a patient with AIDS

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