AIE Polymers: Synthesis, Properties, and Biological Applications

Zhan, Ruoyu; Pan, Yutong; Manghnani, Purnima Naresh; Liu, Bin

doi:10.1002/mabi.201600433

Cited by 124 publications

(69 citation statements)

References 52 publications

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“…With the flexible alkyl spacers existing in P Ia and P Ib , they are expected to exhibit AIE characteristics instead of the AEE effect, which are often observed in polymers bearing TPE or silole moieties . We thus investigated their photoluminescence (PL) behaviors in solution and aggregate states.…”

Section: Resultsmentioning

confidence: 99%

Metal‐Free Poly‐Cycloaddition of Activated Azide and Alkynes toward Multifunctional Polytriazoles: Aggregation‐Induced Emission, Explosive Detection, Fluorescent Patterning, and Light Refraction

Quan

et al. 2017

Macromol. Rapid Commun.

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The metal‐free click polymerization (MFCP) of activated alkynes and azides or activated azide and alkynes have been developed into powerful techniques for the construction of polytriazoles without the obsession of metallic catalyst residues problem. However, the MFCP of activated azides and alkynes is rarely applied in preparation of functional polytriazoles. In this paper, soluble multifunctional polytriazoles (PIa and PIb) with high weight‐average molecular weights (Mw up to 32 000) are prepared via the developed metal‐free poly‐cycloaddition of activated azide and alkynes in high yields (up to 90%). The resultant PIa and PIb are thermally stable, and show aggregation‐induced emission characteristics, enabling their aggregates to detect explosives with superamplification effect. Moreover, thanks to their containing aromatic rings and polar moieties, PIa and PIb exhibit high refractive indices. In addition, they can also be cross‐linked upon UV irradiation to generate 2D fluorescent patterning due to their remaining azide groups and containing ester groups. Thus, these multifunctional polytriazoles are potentially applicable in the optoelectronic and sensing fields.

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Section: Resultsmentioning

confidence: 99%

Metal‐Free Poly‐Cycloaddition of Activated Azide and Alkynes toward Multifunctional Polytriazoles: Aggregation‐Induced Emission, Explosive Detection, Fluorescent Patterning, and Light Refraction

Quan

et al. 2017

Macromol. Rapid Commun.

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“…Besides SWCNTs, a totally new type nanomaterial called aggregation‐induced emission (AIE) makes a great contribution to the optimization of fluorescent imaging. AIE is a phenomenon that a dye displays boosted emission when it transforms from isolated molecular states to aggregated states . It has a board emission range from UV–vis to NIR region and has stable fluorescence as well as low cytotoxicity.…”

Section: Imagingmentioning

confidence: 99%

Recent Progress of Nanomedicine in the Treatment of Central Nervous System Diseases

Feng

Wang

Xue

2020

Advanced Therapeutics

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Central nervous system (CNS) diseases, mainly including neurodegenerative diseases and psychiatric diseases, have become the leading cause of death and disability in the world today, which bring huge suffering to both patients and their families. Nanomedicine is an emerging and rapidly evolving discipline that mainly involves the application of nanoparticles in the diagnosis and treatment of various diseases. Although many challenges in the clinical application of nanomedicine still exist, the prospects for development cannot be ignored. Furthermore, better outcomes for patients with CNS diseases can be expected with the rapid development of nanotechnology in diagnosis and treatment. In the present review, an overview is given of the outstanding recent progress of nanomedicine from three aspects: drug delivery, imaging, and therapy in CNS diseases.

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“…Methods based on fluorescence detection have been developed because of its high sensitivity and excellent repeatability. However, conventional fluorescent probes are highly emissive in solutions but their emission mostly decreased or is totally quenched in the aggregate and solid states, that is, they undergo aggregation-caused quenching (ACQ) effect, which will reduce the sensitivity since the aggregation is a spontaneous process in physiological environments [ 17 , 18 ]. Thus, the ACQ effect has limited their wide applications in related fields, especially in the early sensing applications.…”

Section: Introductionmentioning

confidence: 99%

A specific aggregation-induced emission-conjugated polymer enables visual monitoring of osteogenic differentiation

Zheng

Zhou

et al. 2020

Bioactive Materials

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Osteogenic differentiation is the basis of bone growth and repair related to many diseases, in which evaluating the degree and ability of osteogenic transformation is quite important and highly desirable. However, fixing or stopping the growth of cells is required for conventional methods to monitor osteogenic differentiation, which cannot realize the full investigation of the dynamic process. Herein, a new anion conjugated polymer featuring aggregation-induced emission (AIE) characteristics is developed with excellent solubility for in-situ monitoring the process of osteogenic differentiation. This novel polymer can bind with osteogenic differentiated cells, and the intracellular fluorescence increases gradually with the enhancement of osteogenic differentiation. Moreover, it possesses good biosafety with negligible effect on cell activity and osteogenic differentiation, which cannot be realized by the typical method of Alizarin Red S staining. Further study shows that the polymer crosses the cell membrane through endocytosis and enriches in lysosomes, whereas no obvious fluorescence is detected with other cells, including non-differentiated osteoblast cells, under the same conditions, demonstrating the high selectivity. This is the first fluorescent probe with excellent specificity to realize real-time observation of the process of osteogenic differentiation. Therefore, PTB-EDTA shows great promise in the study of osteogenic differentiation and related applications.

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AIE Polymers: Synthesis, Properties, and Biological Applications

Cited by 124 publications

References 52 publications

Metal‐Free Poly‐Cycloaddition of Activated Azide and Alkynes toward Multifunctional Polytriazoles: Aggregation‐Induced Emission, Explosive Detection, Fluorescent Patterning, and Light Refraction

Metal‐Free Poly‐Cycloaddition of Activated Azide and Alkynes toward Multifunctional Polytriazoles: Aggregation‐Induced Emission, Explosive Detection, Fluorescent Patterning, and Light Refraction

Recent Progress of Nanomedicine in the Treatment of Central Nervous System Diseases

A specific aggregation-induced emission-conjugated polymer enables visual monitoring of osteogenic differentiation

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