AIEgens for dual second harmonic generation and fluorescence “turn-on” imaging of membrane and photodynamic therapy in cancer cells

Abstract

The integration of second harmonic generation (SHG) microscopic imaging and aggregation-induced emission fluorescence imaging would greatly boost the imaging outcomes because of the combination of merits in each imaging modality....

A NIR-Activated and Mild-Temperature-Sensitive Nanoplatform with an HSP90 Inhibitor for Combinatory Chemotherapy and Mild Photothermal Therapy in Cancel Cells

“…Among numerous reported NIR photothermal agents, aza-boron-dipyrrome-thenes (aza-BODIPY) derivatives are photostable materials with a high molar absorption coefficient at the NIR window, a favorable non-radiative excitation decay pathway to efficiently produce photothermal energy, and adjustable photophysical properties and easy functionalization, all of which endow great potential for aza-BODIPY-based PTAs in PTT application [ 28 , 50 , 62 , 63 ]. The donor-acceptor (D-A) molecular engineering favors strong intramolecular charge transfer (ICT) and a narrow energy band gap [ 64 ], which facilitate a redshift of absorption to the NIR window and efficient fluorescent quenching to improve the PTT performance [ 65 , 66 ].…”

“…The large conjugating system of BDPII enabled its high extinction coefficient ( ε ), and the strong charge transfer along the D-A backbone endowed a redshift to the NIR window as well as desirable PCE in the PTT application. As shown in Figure 1 b and Table 1 , the BDPII has two absorbance peaks visible in the NIR region, in which the short absorbance peak at about 639 nm is ascribed to the π-π* transition, and the long wavelength at about 808 nm is due to intramolecular charge transfer (ICT) effect of BDPII [ 64 , 67 , 68 ]. Additionally, the BDPII also exhibits an excellent extinction coefficient at 808 nm of 30,980 mol −1 cm −1 ( Figure 1 c,d).…”

Theranostics with photodynamic therapy for personalized medicine: to see and to treat

“…For example, PSs can be incorporated into lipid-bubbles for photoacoustic imaging, be encapsulated in micelles, or integrated into macromolecular cages. However, inclusion of these strategies is beyond the scope of this review and instead, it is referred to other articles and reviews on the respective topics [22,[35][36][37][38][39][40][41][42][43].…”

“…Therefore, nanoparticles and compounds that induce their effect via aggregation induced emission (AIE) will be excluded. Such compounds have been discussed recently in various articles and reviews, to which we refer here [22,[35][36][37][38][39][40][41][42][43].…”

Tetrasubstituted imidazole derivatives and their imidazolium: photophysical properties in the aggregate state and application for adenosine detection

“…[1][2][3][4] Due to their high sensitivity and selectivity, AIEbased luminogens (AIEgens) have gained considerable attention in applications such as detection and biological imaging. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Recently, several types of AIEgens, mainly including siloles, 21 pyroles, 22 tetraphenylethylenes, [23][24][25] pyrazines, 26 triphenylamines, 27 naphthalenes, 28 and tetraphenyl-1,3-butadiene, 29 have been successfully developed. Experimental studies and theoretical calculations consistently indicate that the restriction of intramolecular motion (RIM) serves as the primary mechanism underlying the AIE effect.…”