AIM Inhibits Apoptosis of T Cells and NKT Cells in Corynebacterium-Induced Granuloma Formation in Mice

Kuwata, Kazuhisa; Watanabe, Hirotaka; Jiang, Shuying; Yamamoto, Takashi; Tomiyama-Miyaji, Chikako; Abo, Toru; Miyazaki, Toru; Naito, Makoto

doi:10.1016/s0002-9440(10)63880-1

Cited by 67 publications

(54 citation statements)

References 43 publications

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“…Second, the major form of P. acnes infection in the prostate gland was stromal intracellular bacteria, which is more consistent with persistent rather than acute infection. The localization of P. acnes in macrophages has been described in both experimentally infected animals and patients with sarcoidosis (15,22,39). P. acnes displays low sensitivity to the bactericidal and degradative functions of human monocytes (38) and may therefore persist intracellularly.…”

Section: Discussionmentioning

confidence: 99%

Direct Visualization ofPropionibacterium acnesin Prostate Tissue by Multicolor Fluorescent In Situ Hybridization Assay

Alexeyev¹,

Marklund²,

Shannon³

et al. 2007

J Clin Microbiol

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Prostate tissues from patients with prostate cancer and benign prostatic hyperplasia (BPH) frequently contain histological inflammation, and a proportion of these patients show evidence of Propionibacterium acnes infection in the prostate gland. We developed a multicolor fluorescent in situ hybridization (FISH) assay targeting P. acnes 23S rRNA along with a 14-kb region of the P. acnes genome. This assay was used to analyze prostate tissues from patients with prostate cancer and BPH. P. acnes infection of the prostate gland was demonstrated in prostatic tissue in 5 of 10 randomly selected prostate cancer patients. FISH analysis and confocal laser microscopy imaging revealed intracellular localization and stromal biofilmlike aggregates as common forms of P. acnes infection in prostate tissues from both prostate cancer and BPH patients. A sequential analysis of prostate tissue from individual patients suggested that P. acnes can persist for up to 6 years in the prostate gland. These results indicate that P. acnes can establish a persistent infection in the prostate gland. Further study is needed to clarify the link between this bacterium and prostatic inflammation which may contribute to the development of BPH and prostate cancer.Clinical benign prostatic hyperplasia (BPH) occurs in half of all men by the age of 80 years (20), while prostate cancer is a leading cause of morbidity and death among men in the United States and Western Europe (13). Chronic or recurrent inflammation has been implicated in the development and progression of both BPH (20) and prostate cancer (9,24,25,30), and various degrees of histological inflammation are seen in the majority of prostate tissue specimens examined. The possibility of an infectious etiology for this prostatic inflammation has been raised in the context of both BPH (20) and prostate cancer, although the accumulation of a larger amount of evidence supports this hypothesis for the latter. For example, epidemiological studies have reported an increased risk of prostate cancer in patients with a history of sexually transmitted infections (29,31,32). The genetic signatures of bacteria were found in prostate tissues from 21 of 107 patients with prostate cancer (21). Moreover, a positive correlation between prostatic inflammation and the detection of bacterial 16S rRNA gene sequences in tissue specimens obtained by radical prostatectomy has been reported (16).Recently, a single bacterial species, Propionibacterium acnes, has been shown to infect a considerable proportion (35%) of prostate glands removed at radical prostatectomy (6). Moreover, the presence of P. acnes was strongly correlated with histological inflammation, suggesting that this bacterium might be linked to cancer development. The possible involvement of P. acnes in prostate pathology was further highlighted by the detection of P. acnes 16S rRNA gene sequences in BPH tissues, with a positive association between the detection of P. acnes DNA and subsequent prostate cancer development reported (1). We have developed ...

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Section: Discussionmentioning

confidence: 99%

Direct Visualization ofPropionibacterium acnesin Prostate Tissue by Multicolor Fluorescent In Situ Hybridization Assay

Alexeyev¹,

Marklund²,

Shannon³

et al. 2007

J Clin Microbiol

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“…It was demonstrated that CD5L supports macrophage survival and enhances the phagocytic function of macrophages in Corynebacterium parvum-induced hepatitis (Haruta et al, 2001). Recently, it was reported that CD5L inhibits the apoptosis of T cells and NKT cells in Corynebacterium-induced granuloma formation in mice (Kuwata et al, 2003). Yusa et al also reported that CD5L induced strong and sustained growth inhibition of B lymphocytes in combination with TGF-β1 (Yusa et al, 1999).…”

Section: Validation Of Cd5l Protein Expression Level In Ad Patients Amentioning

confidence: 99%

Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers

et al. 2008

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Atopic dermatitis (AD) is an inflammatory skin disorder that is both uncomfortable and distressing to patients, and its prevalence has been steadily increasing. It is obvious that the identification of efficient markers of AD in plasma would offer the possibility of effective diagnosis, prevention, and treatment strategies. In this study, a proteomic approach was used to analyze plasma glycoproteins from both children with AD and healthy child donors. Several protein spots showing significant quantitative changes in the AD patients were identified. Through sequential studies, it was confirmed that CD5L and ApoE were significantly up-regulated or down-regulated, respectively, in the plasma from AD patients compared with that from healthy donors. In addition, we suggest that the up-regulated CD5L in AD patients causes eosinophilia by inhibiting apoptosis or promoting the proliferation of eosinophils either in combination with or without IL-5. The glycoproteomic data in this study provides clues to understanding the mechanism of atopic alterations in plasma and suggests AD-related proteins can be used as candidate markers for AD.

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“…4B-D). Previous studies in mice have implicated mSpa in the control of macrophage survival, the protein being a negative regulator of apoptosis [52,53]. It was shown in mice that mSpa is a direct target for regulation by the liver X receptor a [54].…”

Section: Clinical Applications -Biomarker Identificationmentioning

confidence: 99%

Recent advances in blood‐related proteomics

et al. 2005

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Service régional vaudois de transfusion sanguine, Lausanne, SwitzerlandBlood is divided in two compartments, namely, plasma and cells. The latter contain red blood cells, leukocytes, and platelets. From a descriptive medical discipline, hematology has evolved towards a pioneering discipline where molecular biology has permitted the development of prognostic and diagnostic indicators for disease. The recent advance in MS and protein separation now allows similar progress in the analysis of proteins. Proteomics offers great promise for the study of proteins in plasma/serum, indeed a number of proteomics databases for plasma/ serum have been established. This is a very complex body fluid containing lipids, carbohydrates, amino acids, vitamins, nucleic acids, hormones, and proteins. About 1500 different proteins have recently been identified, and a number of potential new markers of diseases have been characterized. Here, examples of the enormous promise of plasma/serum proteomic analysis for diagnostic/prognostic markers and information on disease mechanism are given. Within the blood are also a large number of different blood cell types that potentially hold similar information. Proteomics of red blood cells, until now, has not improved our knowledge of these cells, in contrast to the major progresses achieved while studying platelets and leukocytes. In the future, proteomics will change several aspects of hematology.

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AIM Inhibits Apoptosis of T Cells and NKT Cells in Corynebacterium-Induced Granuloma Formation in Mice

Cited by 67 publications

References 43 publications

Direct Visualization ofPropionibacterium acnesin Prostate Tissue by Multicolor Fluorescent In Situ Hybridization Assay

Direct Visualization ofPropionibacterium acnesin Prostate Tissue by Multicolor Fluorescent In Situ Hybridization Assay

Glycoproteomic analysis of plasma from patients with atopic dermatitis: CD5L and ApoE as potential biomarkers

Recent advances in blood‐related proteomics

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