AIM2 inflammasome: A potential therapeutic target in ischemic stroke

Fu, Rong; Zhao, Linna; Guo, Yuying; Qin, Xiaoli; Xu, Wenzhe; Cheng, Xueqi; Zhang, Yunsha; Xu, Shixin

doi:10.1016/j.clim.2023.109881

Cited by 9 publications

(2 citation statements)

References 127 publications

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“…During the steady state, the PYD and HIN-200 domain interact to maintain AIM2 molecular self-inhibition, while the binding of the HIN-200 domain to the sugar phosphate backbone of dsDNA can relieve the selfinhibition of AIM2 [55]. Thus, in the AIM2 inflammasome, AIM2 acts as an initiator protein that specifically recognizes and binds cytosolic dsDNA through its HIN-200 domain, while ASC connects upstream AIM2 with downstream pro-caspase-1-activating components, thereby priming a canonical activation pathway similar to that of the NLRP3 inflammasome, which triggers pyroptosis and inflammatory response (Figure 2) [56]. Remarkably, it has also been found that AIM2 inflammasome could induce the non-canonical NLRP3 inflammasome activation via the pores formed by GSDMD and subsequent K + efflux [57].…”

Section: Aim2 Inflammasome In Aaamentioning

confidence: 99%

The Role of Inflammasome in Abdominal Aortic Aneurysm and Its Potential Drugs

Pi,

Xiong,

Yuan

et al. 2024

IJMS

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Abdominal aortic aneurysm (AAA) has been recognized as a serious chronic inflammatory degenerative aortic disease in recent years. At present, there is no other effective intervention except surgical treatment for AAA. With the aging of the human population, its incidence is increasing year by year, posing a serious threat to human health. Modern studies suggest that vascular chronic inflammatory response is the core process in AAA occurrence and development. Inflammasome, a multiprotein complex located in the cytoplasm, mediates the expression of various inflammatory cytokines like interleukin (IL)-1β and IL-18, and thus plays a pivotal role in inflammation regulation. Therefore, inflammasome may exert a crucial influence on the progression of AAA. This article reviews some mechanism studies to investigate the role of inflammasome in AAA and then summarizes several potential drugs targeting inflammasome for the treatment of AAA, aiming to provide new ideas for the clinical prevention and treatment of AAA beyond surgical methods.

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Section: Aim2 Inflammasome In Aaamentioning

confidence: 99%

The Role of Inflammasome in Abdominal Aortic Aneurysm and Its Potential Drugs

Pi,

Xiong,

Yuan

et al. 2024

IJMS

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“…A robust inflammatory response occurs after ischemic stroke (Albaqami et al., 2024 ; Fu et al., 2023 ). Ischemic brain tissues release chemokines and cytokines and recruit peripheral circulating neutrophils within hours, followed by lymphocyte (Bui et al., 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Dynamic change of neutrophil‐to‐lymphocyte ratio and its predictive value of prognosis in acute ischemic stroke

Qian,

Hu,

Wang

et al. 2024

Brain and Behavior

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ObjectiveThe present research aimed to explore the dynamic change of the neutrophil‐to‐lymphocyte ratio (NLR) and its relationship with functional outcome following an acute ischemic stroke (AIS), whether receiving intravenous thrombolysis (IVT) or not.MethodsWe retrospectively analyzed data that were prospectively acquired from patients with AIS treated with IVT or not. For patients receiving IVT, the NLR was based on a blood test performed prior to IVT (d0) and at different time points after disease onset (d1, d3, d7). In addition, in the non‐IVT group, the NLR was obtained at different time points after disease onset (d1, d3, d7). Follow‐ups were performed 3 months after onset via telephone. In addition, a good outcome was defined as a modified Rankin scale (mRS) ≤1; a poor outcome means 2 ≤ mRS ≤ 6.ResultsA total of 204 AIS patients were included in this study. The NLR presented a dynamic change as it increased to its peak at day 1 and gradually declined to its baseline at day 7, no matter whether patients were receiving IVT or not. Patients with poor outcomes have a higher NLR at various time points. The results of multivariate logistic regression analysis demonstrated that the National Institutes of Health Stroke Scale (NIHSS), NLR d1, NLR d3, and NLR d7 were independently associated with functional outcomes. The area under the receiver operating characteristic curve of NLR in predicting outcomes was as follows: NLR d3 demonstrated robust predictive power within the IVT therapy cohort, whereas NLR d7 was predictive in the non‐IVT cohort. However, the most potent predictor emerged as the combination of NIHSS and NLR.ConclusionNLR has the potential to predicate diagnosis for AIS, especially when combined with the NIHSS score.

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Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome

Li,

Tian,

et al. 2024

Free Radical Biology and Medicine

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AIM2 inflammasome: A potential therapeutic target in ischemic stroke

Cited by 9 publications

References 127 publications

The Role of Inflammasome in Abdominal Aortic Aneurysm and Its Potential Drugs

The Role of Inflammasome in Abdominal Aortic Aneurysm and Its Potential Drugs

Dynamic change of neutrophil‐to‐lymphocyte ratio and its predictive value of prognosis in acute ischemic stroke

Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in melanoma 2 inflammasome

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