“…Currently, there are limited data about the management of patients with mastocytosis undergoing cardiac surgery with cardiopulmonary bypass (CPB) despite the high theoretical possibility of this type of surgery to act as a trigger for degranulation of MCs. 1,2 We present a case of a 63-year-old woman with severe mitral stenosis secondary to rheumatic disease, mild pulmonary hypertension, and a left ventricular ejection fraction of 44%. The patient was scheduled for mitral valve replacement with a biological prosthesis.…”