“…The term refers to the presence of air in the arterial (cerebral arterial air embolism, CAAE) or venous (cerebral venous air embolism, CVAE) vasculature, the latter being much less frequent than the former (and often underestimated), and, as such, less understood. Most reviews and case reports focus on the more straightforward pathophysiology of the more common CAAE, which can result from paradoxical embolisation or direct entry of air into the arteries or pulmonary veins, as a consequence of cardiac or neurosurgical interventions, high pressure mechanical ventilation, thoracocentesis, central vein manipulation, peripheral vein cannulation and contrast injection, tissue biopsies or endoscopic procedures [1,2] . In contrast, the exact pathophysiology of CVAE remains to be clarified.…”