Air everywhere: colon perforation after colonoscopy

Araújo, Ana Virgínia; Santos, Cláudia Ferreira; Contente, Helena; Branco, Cláudia

doi:10.1136/bcr-2016-219178

Cited by 4 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these, brain-derived neurotrophic factor (BDNF) plays a central role in brain neuronal mechanisms and differentiation of midbrain dopaminergic neurons [27], influencing mood and cognitive functions. Furthermore, BDNF also regulates the immune system [28][29][30]. BDNF is also released in the GI tract, from enterocytes, enteric glial cells, and neurons, representing a neurotransmitter/neuromodulator in enteric neuronal circuitries, thus generating a control of peristalsis and gut motility.…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Adiponectin Role in Neurodegenerative Diseases: Focus on Nutrition Review

Polito

Meo

Barbieri

et al. 2020

IJMS

View full text Add to dashboard Cite

Adiponectin is an adipokine produced by adipose tissue. It has numerous beneficial effects. In particular, it improves metabolic effects and glucose homeostasis, lipid profile, and is involved in the regulation of cytokine profile and immune cell production, having anti-inflammatory and immune-regulatory effects. Adiponectin’s role is already known in immune diseases and also in neurodegenerative diseases. Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are a set of diseases of the central nervous system, characterized by a chronic and selective process of neuron cell death, which occurs mainly in relation to oxidative stress and neuroinflammation. Lifestyle is able to influence the development of these diseases. In particular, unhealthy nutrition on gut microbiota, influences its composition and predisposition to develop many diseases such as neurodegenerative diseases, given the importance of the “gut-brain” axis. There is a strong interplay between Adiponectin, gut microbiota, and brain-gut axis. For these reasons, a healthy diet composed of healthy nutrients such as probiotics, prebiotics, polyphenols, can prevent many metabolic and inflammatory diseases such as neurodegenerative diseases and obesity. The special Adiponectin role should be taken into account also, in order to be able to use this component as a therapeutic molecule.

show abstract

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Adiponectin Role in Neurodegenerative Diseases: Focus on Nutrition Review

Polito

Meo

Barbieri

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…Only one case reported pneumothorax and three extraperitoneal perforation after diagnostic colonoscopy. These cases were treated with conservative therapy of bowel rest, total parenteric nutrition (TPN), endoscopic repair, or laparotomy with anastomosis [9][10][11][12]. Other extraperitoneal manifestations, such as subcutaneous emphysema and mediastinal air, result from communication of fascial planes, mostly near large vessels that connect with cervical soft tissue between the mediastinum and retroperitoneum [6,13].…”

Section: Introductionmentioning

confidence: 99%

Intraperitoneal and Extraperitoneal Colonic Perforation Following Diagnostic and Therapeutic Colonoscopy with Crohn’s-related Stricture Dilation

Weng

Valencia

Krudy

et al. 2020

Cureus

View full text Add to dashboard Cite

Colonic perforation is an uncommon but known and feared complication of colonoscopy, which carries a high mortality rate. We present an uncommon case of extensive intra-and extraperitoneal air following colonic perforation in a patient undergoing inpatient colonoscopy for evaluation of unintentional weight loss and constipation. During colonoscopy, a splenic flexure stricture was identified and dilated. Postprocedural hemodynamic instability prompted further imaging which revealed pneumoperitoneum, bilateral pneumothorax, pneumomediastinum, pneumopericardium, and severe subcutaneous emphysema. Emergent exploratory laparotomy found perforation of the proximal transverse colon which required resection and transverse colostomy placement. The patient also underwent bilateral chest tube placement and was treated with antibiotics for peritonitis. The patient was eventually diagnosed with Crohn's disease and discharged to an extended care facility with outpatient follow-up. Extraperitoneal colonic perforations are fairly rare, and to our knowledge, we present the most severe case that has been published in recent years.

show abstract

Nutritional modulation of the intestinal microbiota; future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease

Lombardi

Meirleir

Subramanian

et al. 2018

The Journal of Nutritional Biochemistry

View full text Add to dashboard Cite

The gut-brain axis refers to the bidirectional communication between the enteric nervous system and the central nervous system. Mounting evidence supports the premise that the intestinal microbiota plays a pivotal role in its function and has led to the more common and perhaps more accurate term gut-microbiota-brain axis. Numerous studies have identified associations between an altered microbiome and neuroimmune and neuroinflammatory diseases. In most cases, it is unknown if these associations are cause or effect; notwithstanding, maintaining or restoring homeostasis of the microbiota may represent future opportunities when treating or preventing these diseases. In recent years, several studies have identified the diet as a primary contributing factor in shaping the composition of the gut microbiota and, in turn, the mucosal and systemic immune systems. In this review, we will discuss the potential opportunities and challenges with respect to modifying and shaping the microbiota through diet and nutrition in order to treat or prevent neuroimmune and neuroinflammatory disease.

show abstract

Air everywhere: colon perforation after colonoscopy

Cited by 4 publications

References 7 publications

Adiponectin Role in Neurodegenerative Diseases: Focus on Nutrition Review

Adiponectin Role in Neurodegenerative Diseases: Focus on Nutrition Review

Intraperitoneal and Extraperitoneal Colonic Perforation Following Diagnostic and Therapeutic Colonoscopy with Crohn’s-related Stricture Dilation

Nutritional modulation of the intestinal microbiota; future opportunities for the prevention and treatment of neuroimmune and neuroinflammatory disease

Contact Info

Product

Resources

About