Air Filtering Capacity of an Integrated Cardio-Pulmonary Bypass Unit

Xm, Mueller; Ht, Tevaearai; Jegger, D.; Lk, von Segesser

doi:10.1097/00002480-200203000-00030

Cited by 2 publications

(2 citation statements)

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“…3 Different ultrasound systems have different levels of sensitivity for counting the number and size of gaseous microemboli. Generally, current regular Doppler systems are able to count gaseous microemboli as small as 40 m. 6,7,20 Many factors, such as angle of orientation, coating of acoustic gel and unstable attachment between transducer and connector, could influence gaseous microemboli count. In our present study, we used this novel EDAC TM QUANTIFIER, which is an effective monitoring and characterizing tool with a high level of sensitivity that can count diameters from 10 m to the connector diameter, classify the microemboli by size from 0 -20 to 20 -40 m and so on.…”

Section: Discussionmentioning

confidence: 99%

Detection and Classification of Gaseous Microemboli During Pulsatile and Nonpulsatile Perfusion in a Simulated Neonatal CPB Model

Ündar

Kunselman

et al. 2007

ASAIO Journal

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We compared the effects of perfusion modes (pulsatile vs. nonpulsatile) on gaseous microemboli delivery using the Emboli Detection and Classification (EDAC) Quantifier at postpump, postoxygenator, and postarterial filter sites in a simulated pediatric cardiopulmonary bypass (CPB) model. The mock loop was subjected to five different pump flow rates of equal 100 ml/min intervals, ranging from 400 to 800 ml/min. When the target pump flow rate was achieved, 5 cc air was introduced into the venous line. The EDAC system recorded gaseous microemboli counts simultaneously at three locations in 5-minute intervals. Regardless of the type of perfusion mode, when the pump flow rate was increased, more gaseous microemboli were generated at postpump site. Compared with nonpulsatile flow, pulsatile flow did deliver significantly more gaseous microemboli at postpump site, but there was no difference between two groups at postoxygenator and postarterial filter sites. Capiox Baby-RX hollow-fiber membrane oxygenator significantly reduced the gaseous microemboli counts in both groups at all five pump flow rates with either pulsatile flow or nonpulsatile flow in this model. Our results suggest that using this novel EDAC system, we could detect the size of gaseous microemboli, as small as 10 microm, and the percentage of detected gaseous microemboli, <40 microm, was about 90% in total gaseous microemboli counts at any flow rate with pulsatile or nonpulsatile flow.

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Section: Discussionmentioning

confidence: 99%

Detection and Classification of Gaseous Microemboli During Pulsatile and Nonpulsatile Perfusion in a Simulated Neonatal CPB Model

Ündar

Kunselman

et al. 2007

ASAIO Journal

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“…To solve these problems, a minimized closed‐loop bypass system (CORx, CardioVention, Inc., Santa Clara, CA, USA) with an automatic integrated deairing unit (AIRVAC, CardioVention, Inc.) was developed a few years ago. Ultrasound bubble measurements in an animal model revealed excellent air elimination capacity of this system (24). Hence, this innovative integrated device for deairing, oxygenation, and blood pumping became trendsetting for the development of several new minimized heart‐lung machines.…”

Section: Discussionmentioning

confidence: 98%

A New Minimized Perfusion Circuit Provides Highly Effective Ultrasound Controlled Deairing

et al. 2007

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Minimized perfusion circuits (MPCs) have been criticized for insufficient air elimination. The deairing capabilities of a new MPC, including an ultrasound controlled deairing unit, were compared to a standard extracorporeal circuit (ECC) in a laboratory setup. During blood flow of 4.0l/min, we injected 30-cc air over a period of 30 s into the venous line of both systems (n = 10 measurements/15-min intervals). Air was detected during the first 2 min post injection using a dual-channel ultrasound bubble counter. Venous air bubble measurements were made after the MPC bubble trap and the ECC hard-shell reservoir, respectively. Arterial air bubble data were obtained after the arterial filters (40 microm). Venous bubble count was significantly (P < 0.01) reduced in the MPC group (5-250 microm, 681 +/- 177; >40 microm, 288 +/- 92) compared with the ECC group (5-250 microm, 19 272 +/- 682; >40 microm, 7642 +/- 520). After the arterial filter, minimal numbers of air bubbles (5-250 microm, 172 +/- 59; >40 microm, 0) could be detected in the MPC group, but large amounts of air (5-250 microm, 16 194 +/- 1072; >40 microm, 3732 +/- 997) were measured in the ECC group. The air elimination of the modern MPC is superior to conventional ECC, which may result in a reduction of neurological complications.

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Air Filtering Capacity of an Integrated Cardio-Pulmonary Bypass Unit

Cited by 2 publications

References 0 publications

Detection and Classification of Gaseous Microemboli During Pulsatile and Nonpulsatile Perfusion in a Simulated Neonatal CPB Model

Detection and Classification of Gaseous Microemboli During Pulsatile and Nonpulsatile Perfusion in a Simulated Neonatal CPB Model

A New Minimized Perfusion Circuit Provides Highly Effective Ultrasound Controlled Deairing

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