Air Pollutant impacts on the brain and neuroendocrine system with implications for peripheral organs: a perspective

Kodavanti, Urmila P.; Jackson, Thomas W.; Henriquez, Andres R.; Snow, Samantha J.; Alewel, Devin I.; Costa, Daniel L.

doi:10.1080/08958378.2023.2172486

Cited by 8 publications

(2 citation statements)

References 165 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Air pollution mainly includes particulate matter (PM 2.5 , PM 10 ), ozone (O 3 ), nitrogen dioxide (NO 2 ) and sulphur dioxide (SO 2 ). A large number of studies in various countries have shown that air pollutants are associated with a variety of systemic diseases in the human body [ 1 , 2 ].such as the nervous system [ 3 ],the immune system [ 4 ],the endocrine system [ 5 ]and the reproductive system [ 6 ]. Air particulate matter can enter the body and cause direct damage to the respiratory tract [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The relationship between air pollutants and preterm birth and blood routine changes in typical river valley city

Li,

Gu,

Liu

et al. 2024

BMC Public Health

View full text Add to dashboard Cite

Objective To collect maternal maternity information on preterm births in two tertiary hospitals in the urban area of Baota District, Yan'an City, from January 2018 to December 2020, to explore the long-term and short-term effects of air pollutants (PM2.5, PM10, SO2, NO2, CO and O3) and preterm births, and to explore changes in blood cell counts due to air pollutants. Methods Daily average mass concentration data of six air pollutants in the urban area of Yan'an City from January 1, 2017 to December 31, 2020 were collected from the monitoring station in Baota District, Yan'an City. Meteorological information was obtained from the Meteorological Bureau of Yan'an City, including temperature,relative humidity and wind speed for the time period. The mass concentration of air pollutants in each exposure window of pregnant women was assessed by the nearest monitoring station method, and conditional logistic regression was used to analyze the relationship between air pollutants and preterm births, as well as the lagged and cumulative effects of air pollutants. Multiple linear regression was used to explore the relationship between air pollutants and blood tests after stepwise linear regression was used to determine confounders for each blood test. Results The long-term effects of pollutants showed that PM2.5, PM10, SO2, NO2and CO were risk factors for preterm birth. In the two-pollutant model, PM2.5, PM10, SO2 and NO2 mixed with other pollutants were associated with preterm birth. The lagged effect showed that PM2.5, PM10, SO2, NO, and CO were associated with preterm birth; the cumulative effect showed that other air pollutants except O3 were associated with preterm birth. The correlation study between air pollutants and blood indicators showed that air pollutants were correlated with leukocytes, monocytes, basophils, erythrocytes, hs-CRPand not with CRP. Conclusion Exposure to air pollutants is a risk factor for preterm birth. Exposure to air pollutants was associated with changes in leukocytes, monocytes, basophils and erythrocytes and hs-CRP.

show abstract

Section: Introductionmentioning

confidence: 99%

The relationship between air pollutants and preterm birth and blood routine changes in typical river valley city

Li,

Gu,

Liu

et al. 2024

BMC Public Health

View full text Add to dashboard Cite

show abstract

“…Inhaled air pollutants with oxidant and reactive properties have been extensively studied in relation to lung cellular injury mechanisms and cardio-physiological outcomes. However, the contribution of the neuroendocrine stress mechanisms in producing pulmonary, as well as extra-pulmonary effects, has only been recently recognized (Kodavanti et al, 2023). These new ndings demonstrate that air pollutants, regardless of their ability to systemically translocate, induce myriad effects in distant organs.…”

Section: Introductionmentioning

confidence: 99%

Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats

Jackson¹,

House

Henriquez

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Air pollutant exposures have been linked to systemic disease; however, the underlying mechanisms between responses of the target tissue and systemic effects are poorly understood. A prototypic inducer of stress, ozone causes respiratory and systemic multiorgan effects through activation of a neuroendocrine stress response. The goal of this study was to assess transcriptomic signatures of multiple tissues and serum metabolomics to understand how neuroendocrine and adrenal-derived stress hormones contribute to multiorgan health outcomes. Male Wistar Kyoto rats (12–13 weeks old) were exposed to filtered air or 0.8 ppm ozone for 4-hours, and blood/tissues were collected immediately post-exposure. Each tissue had distinct expression profiles at baseline. Ozone changed 1,640 genes in lung, 274 in hypothalamus, 2,516 in adrenals, 1,333 in liver, 1,242 in adipose, and 5,102 in muscle (adjusted p-value < .1, absolute fold-change > 50%). Serum metabolomic analysis identified 863 metabolites, of which 447 were significantly altered in ozone-exposed rats (adjusted p-value < .1, absolute fold change > 20%). A total of 6 genes were differentially expressed in all 6 tissues. Glucocorticoid signaling, hypoxia, and GPCR signaling were commonly changed, but ozone induced tissue-specific changes in oxidative stress, immune processes, and metabolic pathways. Genes upregulated by TNF-mediated NFkB signaling were differentially expressed in all ozone-exposed tissues, but those defining inflammatory response were tissue-specific. Upstream predictor analysis identified common mediators of effects including glucocorticoids, although the specific genes responsible for these predictors varied by tissue. Metabolomic analysis showed major changes in lipids, amino acids, and metabolites linked to the gut microbiome, concordant with transcriptional changes identified through pathway analysis within liver, muscle, and adipose tissues. The distribution of receptors and transcriptional mechanisms underlying the ozone-induced stress response are tissue-specific and involve induction of unique gene networks and metabolic phenotypes, but the shared initiating triggers converge into shared pathway-level responses. This multi-tissue transcriptomic analysis, combined with circulating metabolomic assessment, allows characterization of the systemic inhaled pollutant-induced stress response.

show abstract

Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats

Jackson,

House,

Henriquez

et al. 2023

Metabolomics

View full text Add to dashboard Cite

Air Pollutant impacts on the brain and neuroendocrine system with implications for peripheral organs: a perspective

Cited by 8 publications

References 165 publications

The relationship between air pollutants and preterm birth and blood routine changes in typical river valley city

The relationship between air pollutants and preterm birth and blood routine changes in typical river valley city

Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats

Multi-tissue transcriptomic and serum metabolomic assessment reveals systemic implications of acute ozone-induced stress response in male Wistar Kyoto rats

Contact Info

Product

Resources

About