Air Pollution and Asthma: Critical Targets for Effective Action

Kelly, Frank J.; Mudway, Ian; Fussell, Julia C.

doi:10.1007/s41030-020-00138-1

Cited by 10 publications

(4 citation statements)

References 59 publications

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“…A comparison of these models demonstrates a high level of chemical contaminants present in both ground level urban air and offshore landward air. This has been shown to worsen the symptoms of asthma (36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46) and increase the incidence of COPD (47)(48)(49)(50) and pneumonia (51)(52)(53)(54). Most of these health effects are also attributed to climatic conditions and shipping activities.…”

Section: Resultsmentioning

confidence: 99%

Financing Costs and Health Effects of Air Pollution in the Tri-City Agglomeration

Czechowski

Piksa

Dąbrowiecki

et al. 2022

Front. Public Health

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This paper examines the relationship between the presence of air pollution and incidence of selected respiratory diseases in the urban population of the Tri-City agglomeration. The study takes into consideration the specific character of the region, relating to coastal, and port-based shipping. Three research hypotheses formulated the study. General regression models were used to identify the health effects of air pollution and developed health costs were calculated in relation to the treatment of diseases. The findings have shown that air pollution and climatic conditions in the Tri-City aggravate the symptoms of bronchial asthma, while also increasing the number of cases of exacerbated chronic obstructive pulmonary disease and pneumonia. The evidence demonstrates the negative impact of shipping on the health condition of the inhabitants. The calculations have shown the extent of financial losses incurred in connection with the treatment of diseases found to have been caused by air pollution. The estimated health costs turned out to be significant for each of the examined diseases. The financial inefficiency of the Polish health care system has also been demonstrated. All the models have been identified for monthly data for the first time.

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Section: Resultsmentioning

confidence: 99%

Financing Costs and Health Effects of Air Pollution in the Tri-City Agglomeration

Czechowski

Piksa

Dąbrowiecki

et al. 2022

Front. Public Health

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“…Strategies for managing pollution-exacerbated asthma include educating the public, reducing pollution, air quality regulation, monitoring hospitalizations, and providing evidence-based counseling. Healthcare staff need reliable local data on air pollution and patients should be asked about their work environments and exposure locations, access to quality educational materials is also critical for the population [ 69 , 70 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model

dos Santos,

Righetti,

do Nascimento Camargo

et al. 2024

J Inflamm

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Introduction Pollution harms the health of people with asthma. The effect of the anti-inflammatory cholinergic pathway in chronic allergic inflammation associated to pollution is poorly understood. Methods One hundred eight animals were divided into 18 groups (6 animals). Groups included: wild type mice (WT), genetically modified with reduced VAChT (VAChTKD), and those sensitized with ovalbumin (VAChTKDA), exposed to metal powder due to iron pelletizing in mining company (Local1) or 3.21 miles away from a mining company (Local2) in their locations for 2 weeks during summer and winter seasons. It was analyzed for hyperresponsivity, inflammation, remodeling, oxidative stress responses and the cholinergic system. Results During summer, animals without changes in the cholinergic system revealed that Local1 exposure increased the hyperresponsiveness (%Rrs, %Raw), and inflammation (IL-17) relative to vivarium animals, while animals exposed to Local2 also exhibited elevated IL-17. During winter, animals without changes in the cholinergic system revealed that Local2 exposure increased the hyperresponsiveness (%Rrs) relative to vivarium animals. Comparing the exposure local of these animals during summer, animals exposed to Local1 showed elevated %Rrs, Raw, and IL-5 compared to Local 2, while in winter, Local2 exposure led to more IL-17 than Local1. Animals with VAChT attenuation displayed increased %Rrs, NFkappaB, IL-5, and IL-13 but reduced alpha-7 compared to animals without changes in the cholinergic system WT. Animals with VAChT attenuation and asthma showed increased the hyperresponsiveness, all inflammatory markers, remodeling and oxidative stress compared to animals without chronic lung inflammation. Exposure to Local1 exacerbated the hyperresponsiveness, oxidative stressand inflammation in animals with VAChT attenuation associated asthma, while Local2 exposure led to increased inflammation, remodeling and oxidative stress. Conclusions Reduced cholinergic signaling amplifies lung inflammation in a model of chronic allergic lung inflammation. Furthermore, when associated with pollution, it can aggravate specific responses related to inflammation, oxidative stress, and remodeling.

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“…Exposure to air pollutants and tobacco smoke promotes immunoglobulin (Ig) E synthesis, resulting in allergen sensitisation and increasing the risk of developing asthma [11,12]. In atopic asthma, allergen exposure is an aggravating factor in both children and adults [13,14].…”

Section: Introductionmentioning

confidence: 99%

Scanning Electron and Atomic Force Microscopic Analysis of Erythrocytes in a Cohort of Atopic Asthma Patients—A Pilot Study

Alummoottil

Rooy

Bester

et al. 2023

Hemato

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Background: Non-communicable diseases are often associated with chronic inflammation, placing patients suffering from these conditions at a higher risk of thrombosis and other complications. The pathophysiology of asthma and/or atopic asthma is also linked to chronic inflammation, which consequently may alter blood parameters including erythrocyte structure and function. Methodology: The objective of this study was to evaluate differences in erythrocytes between patients with atopic asthma (n = 30) and healthy individuals (n = 30) by evaluating routine haematological parameters; structures and axial ratios of erythrocytes using light microscopy; erythrocyte membrane elasticity using atomic force microscopy; and erythrocyte ultrastructure using scanning electron microscopy. Results: The haematological findings of healthy participants and patients suffering from asthma were within normal clinical ranges together with significantly higher levels of circulating monocytes (p = 0.0066), erythrocytes (p = 0.0004), haemoglobin (p = 0.0057), and haematocrit (p = 0.0049) in asthma patients. The analysis of eosin-stained erythrocytes by light microscopy showed more echinocytes, acanthocytes, and ovalocytes compared to controls and a significant difference in axial ratios (p < 0.0001). Atomic force microscopy findings showed reduced erythrocyte membrane elasticity in asthmatic erythrocytes (p = 0.001). Ultrastructural differences in erythrocytes were visible in the asthma group compared to controls. Conclusion: Altered erythrocyte ultrastructural morphology and a significant change in the haematological profile are evident in atopic asthma and may influence common complications associated with asthma. The impact of these changes on the physiological mechanisms of coagulation and the pathophysiology of asthma needs to be further elucidated.

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Air Pollution and Asthma: Critical Targets for Effective Action

Cited by 10 publications

References 59 publications

Financing Costs and Health Effects of Air Pollution in the Tri-City Agglomeration

Financing Costs and Health Effects of Air Pollution in the Tri-City Agglomeration

Effect of VAChT reduction on lung alterations induced by exposure to iron particles in an asthma model

Scanning Electron and Atomic Force Microscopic Analysis of Erythrocytes in a Cohort of Atopic Asthma Patients—A Pilot Study

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