Air Pollution and Headache Disorders

Mehndiratta, Manmohan; Garg, Divyani; Wasay, Mohammad; Aggarwal, Vasundhara

doi:10.4103/aian.aian_1138_21

Cited by 7 publications

(7 citation statements)

References 50 publications

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“…Two recent publications have briefly reviewed associations between air pollution and headache and/or migraine 13,55 . The overall conclusions of these papers are in agreement with our results.…”

Section: Discussionsupporting

confidence: 92%

“…4,6,9 Two recent publications have briefly reviewed associations between air pollution and headache and/or migraine. 13,55 The overall conclusions of these papers are in agreement with our results. A scoping review that included a summary of air pollution and headache 55 reported point estimates above the null value for associations between migraine outcomes and carbon monoxide, nitrogen dioxide, ozone, PM 2.5 , and PM 10 .…”

Section: Discussionsupporting

confidence: 90%

“…This review builds upon limited existing work summarizing associations between air pollution and migraine and/or headache 13–15 . Specifically, we believe this review represents the first systematic search for studies of air pollution and migraine, assessment of risk of bias, and synthesis of the available data.…”

Section: Introductionmentioning

confidence: 99%

“…This review builds upon limited existing work summarizing associations between air pollution and migraine and/or headache. [13][14][15] Specifically, we believe this review represents the first systematic search for studies of air pollution and migraine, assessment of risk of bias, and synthesis of the available data. Reflecting the studies to date, our review includes short-and long-term studies and a wide variety of air pollution exposures and migraine outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Migraine and air pollution: A systematic review

Portt,

Orchard,

Chen

et al. 2023

Headache

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ObjectiveTo systematically synthesize evidence from a broad range of studies on the association between air pollution and migraine.BackgroundAir pollution is a ubiquitous exposure that may trigger migraine attacks. There has been no systematic review of this possible association.MethodsWe searched for empirical studies assessing outdoor air pollution and any quantified migraine outcomes. We included short‐ and long‐term studies with quantified air pollution exposures. We excluded studies of indoor air pollution, perfume, or tobacco smoke. We assessed the risk of bias with the World Health Organization's bias assessment instrument for air quality guidelines.ResultsThe final review included 12 studies with over 4,000,000 participants. Designs included case‐crossover, case–control, time series, and non‐randomized pre–post intervention. Outcomes included migraine‐related diagnoses, diary records, medical visits, and prescriptions. Rather than pooling the wide variety of exposures and outcomes into a meta‐analysis, we tabulated the results.Point estimates above 1.00 reflected associations of increased risk. In single‐pollutant models, the percent of point estimates above 1.00 were carbon monoxide 5/5 (100%), nitrogen dioxide 10/13 (78%), ozone 7/8 (88%), PM2.5 13/15 (87%), PM10 2/2 (100%), black carbon 0/1 (0%), methane 4/6 (75%), sulfur dioxide 3/5 (60%), industrial toxic waste 1/1 (100%), and proximity to oil and gas wells 6/13 (46%). In two‐pollutant models, 16/17 (94%) of associations with nitrogen dioxide were above 1.00; however, more than 75% of the confidence intervals included the null value.Most studies had low to moderate risks of bias. Where differences were observed, stronger quality articles generally reported weaker associations.ConclusionsBalancing the generally strong methodologies with the small number of studies, point estimates were mainly above 1.00 for associations of carbon monoxide, nitrogen dioxide, ozone, and particulate matter with migraine. These results were most consistent for nitrogen dioxide.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Migraine and air pollution: A systematic review

Portt,

Orchard,

Chen

et al. 2023

Headache

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“…Data on long-term exposures in relation to migraine are very scarce. However, they suggest that chronic exposure may be important in the etiopathogenesis of migraine ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Associations between migraine and possible risk factors in the Czech Republic

Riedlova,

Zahradnikova,

Skybova

et al. 2023

Front. Neurol.

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IntroductionMigraine is a widespread neurological disorder, growing increasingly common. However, the pathogenesis of the disease is often unclear and the evidence for the role of various risk factors is limited. This study aimed to identify risk factors associated with migraine and to contribute towards a better understanding of this disease.MethodsData from 3,247 questionnaires were analyzed for associations between migraine and sex, age, BMI, degree of education, and air pollution, along with other factors such as contact with friends, physical condition, health, anxiety, and depression. A cross-sectional study was conducted with an approximately equal distribution of the sample by age, gender and two analysed regions. Data were presented using basic descriptive statistics using the chi-square test. The model output was presented using a crude odds ratio (OR) and a fully adjusted OR. Three hundred and eight-six individuals (12%) suffered from migraine.ResultsIn an adjusted model, the presented study found associations between the prevalence of migraine and sex, age, and level of education. Individuals with migraine statistically significantly more often suffered from depression, anxiety and other selected factors. However, the assumed significant association between the occurrence of migraine and pollution in the region has not been found

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Hypoxia, NSAIDs, and autism: A biocultural analysis of stressors in gametogenesis

Burke

2024

American J Hum Biol

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Cultural and generational trends have increasingly favored “anti‐inflammatory” action, innovating a new class of analgesic, non‐steroidal anti‐inflammatory drugs (NSAIDs) in the 20th century. The modern human body has been molded over evolutionary time and while acknowledging inflammation can be pathologically entwined, it also serves an important role in healthy folliculogenesis and ovulation, shaping cues that drive needed vascular change. This review argues that because of anti‐inflammatory action, the cultural invention of NSAIDs represents a particular stressor on female reproductive‐age bodies, interacting with natural, underlying variation and placing limits on healthy growth and development in the follicles, creating potential autism risk through hypoxia and mutagenic or epigenetic effects. Since testes are analogs to ovaries, the biological grounding extends naturally to spermatogenesis. This review suggests the introduction of over‐the‐counter NSAIDs in the 1980s failed to recognize the unique functioning of reproductive‐age bodies, challenging the cyclical inflammation needed for healthy gamete development. NSAIDs are framed as one (notable) stressor in an anti‐inflammatory era focused on taming the risks of inflammation in modern human life.

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Air Pollution and Headache Disorders

Cited by 7 publications

References 50 publications

Migraine and air pollution: A systematic review

Migraine and air pollution: A systematic review

Associations between migraine and possible risk factors in the Czech Republic

Hypoxia, NSAIDs, and autism: A biocultural analysis of stressors in gametogenesis

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