Air pollution and metabolic disorders: Dynamic versus static measures of exposure among Hispanics/Latinos and non-Hispanics

Letellier, Noémie; Zamora, Steven; Spoon, Chad; Yang, Jiue-An; Mortamais, Marion; Carrasco-Escobar, Gabriel; Sears, Dorothy D.; Jankowska, Marta M.; Benmarhnia, Tarik

doi:10.1016/j.envres.2022.112846

Cited by 10 publications

(3 citation statements)

References 55 publications

(85 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…indoor exposures, occupation-related exposures) or capture daily mobility. 45 Lastly, our exposure data were only available for 2000–2016. Annual exposure surfaces for 1997–1999 and 2017–2018 were produced by the temporal calibration.…”

Section: Discussionmentioning

confidence: 99%

Effect modification by statin use status on the association between fine particulate matter (PM2.5) and cardiovascular mortality

Bai,

Kwong,

Kaufman

et al. 2024

International Journal of Epidemiology

View full text Add to dashboard Cite

Background Numerous studies have linked fine particulate matter (PM2.5) to increased cardiovascular mortality. Less is known how the PM2.5-cardiovascular mortality association varies by use of cardiovascular medications. This study sought to quantify effect modification by statin use status on the associations between long-term exposure to PM2.5 and mortality from any cardiovascular cause, coronary heart disease (CHD), and stroke. Methods In this nested case-control study, we followed 1.2 million community-dwelling adults aged ≥66 years who lived in Ontario, Canada from 2000 through 2018. Cases were patients who died from the three causes. Each case was individually matched to up to 30 randomly selected controls using incidence density sampling. Conditional logistic regression models were used to estimate odds ratios (ORs) for the associations between PM2.5 and mortality. We evaluated the presence of effect modification considering both multiplicative (ratio of ORs) and additive scales (the relative excess risk due to interaction, RERI). Results Exposure to PM2.5 increased the risks for cardiovascular, CHD, and stroke mortality. For all three causes of death, compared with statin users, stronger PM2.5-mortality associations were observed among non-users [e.g. for cardiovascular mortality corresponding to each interquartile range increase in PM2.5, OR = 1.042 (95% CI, 1.032–1.053) vs OR = 1.009 (95% CI, 0.996–1.022) in users, ratio of ORs = 1.033 (95% CI, 1.019–1.047), RERI = 0.039 (95% CI, 0.025–0.050)]. Among users, partially adherent users exhibited a higher risk of PM2.5-associated mortality than fully adherent users. Conclusions The associations of chronic exposure to PM2.5 with cardiovascular and CHD mortality were stronger among statin non-users compared to users.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect modification by statin use status on the association between fine particulate matter (PM2.5) and cardiovascular mortality

Bai,

Kwong,

Kaufman

et al. 2024

International Journal of Epidemiology

View full text Add to dashboard Cite

show abstract

“…This dynamic exposure assessment took advantage of the spatiotemporal exposure measures obtained from GPS tracking and has the potential to contribute new insights into exposure-health associations. Finally, while many previous GPS-based studies had study domains limited to a single city [ 9 , 61 – 63 ], we tested our approach based on a nationwide sample from the Netherlands, providing data from diverse environmental settings.…”

Section: Discussionmentioning

confidence: 99%

Short-term exposure sequences and anxiety symptoms: a time series clustering of smartphone-based mobility trajectories

Lan,

Helbich

2023

Int J Health Geogr

View full text Add to dashboard Cite

Background Short-term environmental exposures, including green space, air pollution, and noise, have been suggested to affect health. However, the evidence is limited to aggregated exposure estimates which do not allow the capture of daily spatiotemporal exposure sequences. We aimed to (1) determine individuals’ sequential exposure patterns along their daily mobility paths and (2) examine whether and to what extent these exposure patterns were associated with anxiety symptoms. Methods We cross-sectionally tracked 141 participants aged 18–65 using their global positioning system (GPS) enabled smartphones for up to 7 days in the Netherlands. We estimated their location-dependent exposures for green space, fine particulate matter, and noise along their moving trajectories at 10-min intervals. The resulting time-resolved exposure sequences were then partitioned using multivariate time series clustering with dynamic time warping as the similarity measure. Respondents’ anxiety symptoms were assessed with the Generalized Anxiety Disorders-7 questionnaire. We fitted linear regressions to assess the associations between sequential exposure patterns and anxiety symptoms. Results We found four distinctive daily sequential exposure patterns across the participants. Exposure patterns differed in terms of exposure levels and daily variations. Regression results revealed that participants with a “moderately health-threatening” exposure pattern were significantly associated with fewer anxiety symptoms than participants with a “strongly health-threatening” exposure pattern. Conclusions Our findings support that environmental exposures’ daily sequence and short-term magnitudes may be associated with mental health. We urge more time-resolved mobility-based assessments in future analyses of environmental health effects in daily life.

show abstract

“…Moreover, we could not account for mobility (time-activity) patterns during pregnancy and childhood, which has the potential to introduce pollutant-specific exposure misclassification errors that could bias the associations. 45 Overall, these exposure errors are likely to be nondifferential, possibly contributing to the null association observed between UFPs and childhood asthma onset.…”

Section: Discussionmentioning

confidence: 99%

Exposure to ultrafine particles and the incidence of asthma in children

Fleck

Vachon

Buteau

et al. 2022

Environmental Epidemiology

View full text Add to dashboard Cite

Background: Asthma is the most prevalent chronic respiratory disease in children. The role of ultrafine particles (UFPs) in the development of the disease remains unclear. We used a population-based birth cohort to evaluate the association between prenatal and childhood exposure to low levels of ambient UFPs and childhood-onset asthma. Methods: The cohort included all children born and residing in Montreal, Canada, between 2000 and 2015. Children were followed for asthma onset from birth until <13 years of age. Spatially resolved annual mean concentrations of ambient UFPs were estimated from a land use regression model. We assigned prenatal exposure according to the residential postal code at birth. We also considered current exposure during childhood accounting for time-varying residence location. We estimated hazard ratios (HRs) using Cox proportional hazards models adjusted for age, sex, neighborhood material and social deprivation, calendar year, and coexposure to ambient nitrogen dioxide (NO2) and fine particles (PM2.5). Results: The cohort included 352,966 children, with 30,825 children developing asthma during follow-up. Mean prenatal and childhood UFP exposure were 24,706 particles/cm3 (interquartile range [IQR] = 3,785 particles/cm3) and 24,525 particles/cm3 (IQR = 3,427 particles/cm3), respectively. Both prenatal and childhood UFP exposure were not associated with childhood asthma onset in single pollutant models (HR per IQR increase of 0.99 [95% CI = 0.98, 1.00]). Estimates of association remained similar when adjusting for coexposure to ambient NO2 and PM2.5. Conclusion: In this population-based birth cohort, childhood asthma onset was not associated with prenatal or childhood exposure to low concentrations of UFPs.

show abstract

Air pollution and metabolic disorders: Dynamic versus static measures of exposure among Hispanics/Latinos and non-Hispanics

Cited by 10 publications

References 55 publications

Effect modification by statin use status on the association between fine particulate matter (PM2.5) and cardiovascular mortality

Effect modification by statin use status on the association between fine particulate matter (PM2.5) and cardiovascular mortality

Short-term exposure sequences and anxiety symptoms: a time series clustering of smartphone-based mobility trajectories

Exposure to ultrafine particles and the incidence of asthma in children

Contact Info

Product

Resources

About