Air pollution exposure during pregnancy and spontaneous abortion and stillbirth

Grippo, Alexandra; Chu, Li; Guo, Youguang; Qiao, Lihua; Zhang, Jun; Myneni, Ajay A.; Mu, Lina

doi:10.1515/energyo.0079.00016

Cited by 4 publications

(4 citation statements)

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“…Developing fetuses are considered to be particularly vulnerable to environmental pollution. Several studies have shown that exposure to ambient air pollution (example particulate matter: PM2.5) during pregnancy is associated with low birth weight, preterm delivery, and other adverse health effects (4).…”

Section: Introductionmentioning

confidence: 99%

Associations between the exposure to organophosphate flame retardants during early pregnancy and the risk of spontaneous abortion based on metabolomics combined with tandem mass spectrometry

Li¹,

Lv²,

Zhang³

et al. 2021

Ann Transl Med

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Background: As potential substitutes for polybrominated diphenyl ethers (PBDEs), organophosphate flame retardants (OPFRs) have been frequently detected in the environment. They have been suggested to impair fetal growth and development in toxicological studies. However, there are few studies on their maternal effects before or during early pregnancy.Methods: This study was designed to investigate whether exposure to OPFRs before or during early pregnancy is associated with the risk of spontaneous abortion (SAB), using a nested case-control design based on the case data from clinical examinations in Shanghai, China. A total of 110 cases from this cohort project in 2019-2020 were included. The concentrations of OPFRs in maternal urine samples collected in early pregnancy were determined using Ultra high performance liquid chromatography-triple quadrupole mass spectrometer (UHPLC-MS/MS), and pregnancy outcomes were extracted from the medical records.Meanwhile, ultra high performance liquid chromatography time-of-flight mass spectrometer (UHPLC-Q-TOF/MS)-based metabonomics was used to obtain urine metabolic profiles of 110 women in early pregnancy.Results: According to the quantitative results, the content of bis(1-chloro-2-propyl)phosphate (BCIPP) in urine was significantly different between the SAB patients and the healthy pregnant women. Besides, metabolic profile analysis showed a significant difference in the urine metabolism profile in early pregnancy between SAB cases and controls. Twenty-five different metabolites were screened out, which showed different degrees of correlation with the urinary BCIPP concentration.Conclusions: Based on these results, it suggests that there may be a certain correlation between BCIPP concentration in the urine and the risk of SAB from a metabolomics perspective, and its effect may be related to the metabolism of tryptophan and fatty acids.

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Section: Introductionmentioning

confidence: 99%

Associations between the exposure to organophosphate flame retardants during early pregnancy and the risk of spontaneous abortion based on metabolomics combined with tandem mass spectrometry

Li¹,

Lv²,

Zhang³

et al. 2021

Ann Transl Med

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“…In addition, more recent studies suggest that exposure to air pollutants such as particulate matter or cooking smoke may also be associated with higher risk of abortion. However, exposure to carbon monoxide showed inconsistent results, and no clear evidence was found for other pollutants like heavy metals or organochlorine compounds [5].…”

Section: Introductionmentioning

confidence: 99%

Environmental Exposure during Pregnancy: Influence on Prenatal Development and Early Life: A Comprehensive Review

et al. 2021

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Preconception and prenatal exposure to environmental contaminants may affect future health. Pregnancy and early life are critical sensitive windows of susceptibility. The aim of this review was to summarize current evidence on the toxic effects of environment exposure during pregnancy, the neonatal period, and childhood. Alcohol use is related to foetal alcohol spectrum disorders, foetal alcohol syndrome being its most extreme form. Smoking is associated with placental abnormalities, preterm birth, stillbirth, or impaired growth and development, as well as with intellectual impairment, obesity, and cardiovascular diseases later in life. Negative birth outcomes have been linked to the use of drugs of abuse. Pregnant and lactating women are exposed to endocrine-disrupting chemicals and heavy metals present in foodstuffs, which may alter hormones in the body. Prenatal exposure to these compounds has been associated with pre-eclampsia and intrauterine growth restriction, preterm birth, and thyroid function. Metals can accumulate in the placenta, causing foetal growth restriction. Evidence on the effects of air pollutants on pregnancy is constantly growing, for example, preterm birth, foetal growth restriction, increased uterine vascular resistance, impaired placental vascularization, increased gestational diabetes, and reduced telomere length. The advantages of breastfeeding outweigh any risks from contaminants. However, it is important to assess health outcomes of toxic exposures via breastfeeding. Initial studies suggest an association between pre-eclampsia and environmental noise, particularly with early-onset pre-eclampsia. There is rising evidence of the negative effects of environmental contaminants following exposure during pregnancy and breastfeeding, which should be considered a major public health issue.

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“…Detrimental effects of air pollution on SAB have been previously suggested with exposure to particulate matter (PM) and some gaseous pollutants [11. Most of the previous studies reported strong associations of high PM [12][13][14][15], sulfur dioxide (SO 2 ) [16,17] and ozone (O 3 ) [12,15,18] exposure with increased risk of SAB. However, evidence regarding nitrogen dioxide (NO 2 ) and carbon monoxide (CO) are insu cient and less inclusive, suggesting more studies are warranted to better understand their associations with SAB risk [11].…”

Section: Introductionmentioning

confidence: 99%

Nitrogen Dioxide Exposure During Pregnancy and Risk of Spontaneous Abortion: A Case-control Study in China

Wang

Sheng

et al. 2020

Preprint

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Background Evidence on the relationship between prenatal exposure to NO2 and CO and spontaneous abortion (SAB) is insufficient. We investigated whether there is an association between maternal exposure to nitrogen dioxide (NO2) and carbon monoxide (CO) before and during pregnancy and SAB. Methods We conducted a case-control study using medical records of 2445 pregnant women who admitted for abortion prior to 20 weeks of gestational age from January 2014 to December 2019 at a tertiary-care hospital in Shanghai, China. Of the 2445 participants, 1075 were SAB cases and 1370 were healthy controls (underwent elective abortions). Maternal exposure to NO2 and CO before and during pregnancy was estimated using daily air pollution concentration data. Multivariable logistic regression models were constructed to quantify the relationships between maternal exposure to NO2 or CO and the risk of SAB while controlling for potential confounders. Results NO2 exposure levels during pregnancy were significantly higher in SAB cases than in healthy controls (42.26 vs 40.67, P < 0.01). NO2 exposure during pregnancy was positively associated with the risk of SAB. An interquartile range (16 µg/m3) increase in NO2 exposure was associated with 67% increase in the odds of SAB (OR = 1.67, 95% CI, 1.28, 2.18). Analyses of associations by quartile of NO2 exposure showed that elevated NO2 exposure during pregnancy was associated with increased odds of SAB in linear dose-response manners. Compared with the lowest quartile of NO2 exposure, the odds of SAB in the fourth quartile of NO2 exposure increased 60% (OR = 1.60, 95% CI, 1.03–2.49). No associations of CO exposure with SAB risk were observed. Conclusion Our study suggested that exposure to NO2 during early pregnancy was associated with increased risk of SAB. Further studies are need to confirm our results and explore the potential biological mechanism underlying these associations.

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Air pollution exposure during pregnancy and spontaneous abortion and stillbirth

Cited by 4 publications

References 0 publications

Associations between the exposure to organophosphate flame retardants during early pregnancy and the risk of spontaneous abortion based on metabolomics combined with tandem mass spectrometry

Associations between the exposure to organophosphate flame retardants during early pregnancy and the risk of spontaneous abortion based on metabolomics combined with tandem mass spectrometry

Environmental Exposure during Pregnancy: Influence on Prenatal Development and Early Life: A Comprehensive Review

Nitrogen Dioxide Exposure During Pregnancy and Risk of Spontaneous Abortion: A Case-control Study in China

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