Study of indoor air quality (IAQ) has received attention of the researchers and policy makers over the last several years due to its affiliation with the adverse health effects and occupants' discomfort. This article focuses on the importance and need of IAQ studies in Indian rural and urban indoor environments. A number of questions in this context are posed and addressed, together with identifying the allied research gaps and missing links in the existing literature. Also discussed are the technical challenges to carry out the IAQ studies in India, and the initiatives and future road map required to overcome them.