Air pollution, oxidative stress, and exacerbation of autoimmune diseases

Gawda, Anna; Majka, Grzegorz; Nowak, Bernadeta; Marcinkiewicz, Janusz

doi:10.5114/ceji.2017.70975

Cited by 92 publications

(56 citation statements)

References 115 publications

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“…Increases in the levels of different ROS species may lead to oxidative stress through disruption of the balance between oxidant and antioxidant molecules, leading to tissue damage (to DNA, lipids and proteins [31,32,53](. It has previously been shown that the transcription factor Nrf2 and its related genes are involved in the response to PM exposure [31,32].…”

Section: Early Apoptotic Cells Can Become Late Apoptotic Cells If Thementioning

confidence: 99%

Mechanisms of lung toxicity induced by biomass burning aerosols

Pardo

et al. 2020

Part Fibre Toxicol

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Background: Carbonaceous aerosols emitted from indoor and outdoor biomass burning are major risk factors contributing to the global burden of disease. Wood tar aerosols, namely, tar ball particles, compose a substantial fraction of carbonaceous emissions, especially from biomass smoldering. However, their health-related impacts and toxicity are still not well known. This study investigated the toxicity of the water-soluble fraction of pyrolyzed wood tar aerosols in exposed mice and lung epithelial cells.Results: Mice exposed to water-soluble wood tar aerosols showed increased inflammatory and oxidative stress responses. Bronchial epithelial cells exposed to the same water-soluble wood tar aerosols showed increased cell death with apoptotic characteristics. Alterations in oxidative status, including changes in reactive oxygen species (ROS) levels and reductions in the expression of antioxidant genes related to the transcription factor Nrf2, were observed and were confirmed by increased levels of MDA, a lipid peroxidation adduct. Damage to mitochondria was observed as an early event responsible for the aforementioned changes. Conclusions:The toxicity and health effect-related mechanisms of water-soluble wood tar were investigated for the first time in the context of biomass burning. Wood tar particles may account for major responses such as cell death, oxidative stress, supression of protection mechnaisms and mitochondrial damaged cause by expsoure to biomass burning aerosols.

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Section: Early Apoptotic Cells Can Become Late Apoptotic Cells If Thementioning

confidence: 99%

Mechanisms of lung toxicity induced by biomass burning aerosols

Pardo

et al. 2020

Part Fibre Toxicol

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“…Under inflammatory conditions, production of ROS is tightly correlated to the generation of another group of redox signaling molecules-reactive nitrogen species (RNS) [11]. RNS are derived from nitric oxide (NO), a product of nitric oxide synthase activity.…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide and peroxynitrite trigger and enhance release of neutrophil extracellular traps

Manda-Handzlik

Bystrzycka

Cieloch

et al. 2019

Cell. Mol. Life Sci.

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Despite great interest, the mechanism of neutrophil extracellular traps (NETs) release is not fully understood and some aspects of this process, e.g. the role of reactive nitrogen species (RNS), still remain unclear. Therefore, our aim was to investigate the mechanisms underlying RNS-induced formation of NETs and contribution of RNS to NETs release triggered by various physiological and synthetic stimuli. The involvement of RNS in NETs formation was studied in primary human neutrophils and differentiated human promyelocytic leukemia cells (HL-60 cells). RNS (peroxynitrite and nitric oxide) efficiently induced NETs release and potentiated NETs-inducing properties of platelet activating factor and lipopolysaccharide. RNS-induced NETs formation was independent of autophagy and histone citrullination, but dependent on the activity of phosphoinositide 3-kinases (PI3K) and myeloperoxidase, as well as selective degradation of histones H2A and H2B by neutrophil elastase. Additionally, NADPH oxidase activity was required to release NETs upon stimulation with NO, as shown in NADPH-deficient neutrophils isolated from patients with chronic granulomatous disease. The role of RNS was further supported by increased RNS synthesis upon stimulation of NETs release with phorbol 12-myristate 13-acetate and calcium ionophore A23187. Scavenging or inhibition of RNS formation diminished NETs release triggered by these stimuli while scavenging of peroxynitrite inhibited NO-induced NETs formation. Our data suggest that RNS may act as mediators and inducers of NETs release. These processes are PI3K-dependent and ROS-dependent. Since inflammatory reactions are often accompanied by nitrosative stress and NETs formation, our studies shed a new light on possible mechanisms engaged in various immune-mediated conditions. Keywords Autophagy • Neutrophil extracellular traps • Nitric oxide • Peroxynitrite • Phosphoinositide 3-kinases • Reactive nitrogen species Abbreviations 3-MA 3-Methyladenine ABAH Aminobenzoic acid hydrazide AKT Protein kinase B CGD Chronic granulomatous disease CI Calcium ionophore A23187 DHR 123 Dihydrorhodamine 123 DPI Diphenyleneiodonium ERK Extracellular signal-regulated kinases IL Interleukin LC3 protein Light chain 3 protein L-NAME N-nitroarginine methyl ester LPS Lipopolysaccharide MAPK Mitogen-activated protein kinases MPO Myeloperoxidase NAC N-acetylcysteine NE Neutrophil elastase NEi Neutrophil elastase inhibitor GW 311616A NETs Neutrophil extracellular traps NBT Nitroblue tetrazolium NO Nitric oxide NOS Nitric oxide synthase Cellular and Molecular Life Sciences Malgorzata Wachowska and Urszula Demkow have contributed equally.

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“…-особенно если действуют на формирующийся организм с детства, не только способны нарушить развитие легких и дыхательной функции, но и производят системные, в том числе опосредованные через пищу и кишечную микробиоту, эффекты в других органах, вплоть до нарушения психомоторного развития и иммунитета [9,20,28,29,34,36]. Механизмы возможного влияния аэрополлютантов на аутоиммунитет могут быть разными: адъювантоподобное действие, индукция таких модификаций антигенов, к которым не толерантны лимфоциты организма, появление неоантигенов в результате действия активных кислород-и галогенсодержащих радикалов и иных медиаторов воспаления [3,30] и пр. Эффекты при этом могут быть разнонаправленными и нетривиальными: так, недавно в Германии была показана обратная связь между степенью экспозиции озоновому загрязнению и среднесрочной метаболической декомпенсацией СД1, оцененной по количеству гликированного гемоглобина [40].…”

Section: результатыunclassified

Связанные С Урбанизацией Факторы Заболеваемости Сахарным Диабетом Первого Типа

Сопрун¹,

Акулин²,

Утехин³

et al. 2019

Biosfera

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Большая часть населения сейчас живет в городских условиях. Профиль загрязнений городской среды изменяется под влиянием автомобильного дорожного комплекса (АДК). Его важнейшим загрязняющим продуктом служат твердые пылевые частицы, в состав которых входят алюмосиликы. Многие соединения алюминия известны как адъюванты, усиливающие иммунный ответ, в том числе на аутоантигены. Сахарный диабет 1-го типа (СД1) – аутоиммунное заболевание. Цель работы – изучить с данных использованием геоинформационных систем (ГИС) особенности медицинской географии СД1 в России и выявить связанные с урбанизацией факторы повышения заболеваемости. Такой подход для исследования распространенности аутоиммунных болезней ранее не применялись. Исследована заболеваемость СД1 в 83 регионах Российской Федерации в 2008-2017 гг. Отмечены более чем 20-кратные различия между регионами РФ по заболеваемости СД1. Самая высокая она в Псковской области (77,31 на 100 тыс. населения), самая низкая – в Республике Дагестан (3,56 на 100 тыс. населения). Установлены достоверные корреляции между заболеваемостью СД1, географической плотностью сети автомобильных дорог с твердым покрытием, ежегодным выбросом загрязняющих атмосферу веществ из стационарных источников и количеством автобусов на 100000 населения. Эффекты первых два факторов мультипликативные, эффект третьего аддитивен к ним.

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Air pollution, oxidative stress, and exacerbation of autoimmune diseases

Cited by 92 publications

References 115 publications

Mechanisms of lung toxicity induced by biomass burning aerosols

Mechanisms of lung toxicity induced by biomass burning aerosols

Nitric oxide and peroxynitrite trigger and enhance release of neutrophil extracellular traps

Связанные С Урбанизацией Факторы Заболеваемости Сахарным Диабетом Первого Типа

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