In order to further improve the interior air quality and comfort of the vehicle, CFD method is used to simulate the different airflow distribution caused by car-mounted air purifiers at different positions. Combined with the change of formaldehyde concentration field in car, the influence of car-mounted air purifiers on the formaldehyde dilution and removal under the condition of air conditioning air supply is analyzed. The simulation results are verified by actual measurement, and the trend of the simulation results is basically consistent with the measured results. When the car air purifier placed in the middle of the car roof, it can effectively dilute and purify the formaldehyde gas in the car, and reduce the concentration of formaldehyde in the breathing area of the driver and passengers. The adsorption and degradation of formaldehyde by the purifier, together with the dilution of formaldehyde by air supply, can improve the air quality in cars more effectively than using only one of the air purification methods.