Air Temperature and Inflammatory and Coagulation Responses in Patients with Coronary or Pulmonary Diseases

Hampel, Regina; Breitner, Susanne; Rückerl, Regina; Frampton, Mark W.; Wichmann, Heinz‐Erich; Peters, Annette; Schneider, Alexandra

doi:10.1097/01.ede.0000362424.21227.0b

Cited by 1 publication

(6 citation statements)

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“…We observed inverse temperature effects on fibrinogen and PAI-1 only in individuals with T2D or IGT. In accordance to our results, Schneider et al 20 and Hampel et al 22 found elevated fibrinogen levels in association with temperature decrements in MI survivors and in participants with pulmonary disease. A decrease of 10°C in the 5-day average of temperature led to a 5.5% (95% CI 1.3% to 9.7%) increase in fibrinogen in pulmonary disease participants,22 which is stronger compared with our observed 1.6% (95% CI 0.5% to 2.7%) increase in fibrinogen for the same temperature decline.…”

Section: Discussionsupporting

confidence: 93%

“…In accordance to our results, Schneider et al 20 and Hampel et al 22 found elevated fibrinogen levels in association with temperature decrements in MI survivors and in participants with pulmonary disease. A decrease of 10°C in the 5-day average of temperature led to a 5.5% (95% CI 1.3% to 9.7%) increase in fibrinogen in pulmonary disease participants,22 which is stronger compared with our observed 1.6% (95% CI 0.5% to 2.7%) increase in fibrinogen for the same temperature decline. Schneider et al 20 detected the strongest increase of fibrinogen of about 1.3% (95% CI 0.2% to 2.4%) for lag 3, which is very similar compared with our observed increase of 1.2% (95% CI 0.2% to 2.2%) for a temperature decrement of 10°C.…”

Section: Discussionsupporting

confidence: 93%

“…In contrast to our initial hypothesis and other studies,20 21 we found decreases in hsCRP and no change in fibrinogen in association with a temperature decrease for participants with the potential genetic predisposition. However, a previous study by Hampel et al 22 also detected a short-term decrease in CRP associated with a drop in temperature. We can only speculate that our findings are a consequence of the special genetic background specified by the null polymorphism of GSTM1 and either two major alleles of the SNP rs1205 located in the CRP gene or at least one minor allele of the SNP rs1800790 located in the fibrinogen gene FGB.…”

Section: Discussionmentioning

confidence: 80%

“…Since procoagulatory and proinflammatory blood markers are predictors for CVD,7–9 temperature effects on blood markers in subjects with diabetes are also of interest as this maybe one possible biological pathway linking temperature changes and mortality in individuals with T2D. Accordingly, Hampel et al 22 observed stronger changes in blood markers of coagulation in association with temperature decreases in participants with a CHD and T2D than in those with a CHD but without T2D. Earlier studies suggested that controlled exposure to cold air or water led to an increase in blood markers like fibrinogen16 and PAI-1 17.…”

Section: Discussionmentioning

confidence: 99%

“…CRP increased due to temperature decreases up to 1 day before blood withdrawal and decreases in the 4-week average of temperature 21. Furthermore, Hampel et al 22 found decreases in CRP and fibrinogen in association with a 10°C temperature decrease in patients with coronary heart disease (CHD).…”

Section: Introductionmentioning

confidence: 99%

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Short-term effects of air temperature on blood markers of coagulation and inflammation in potentially susceptible individuals

et al. 2012

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Objectives Changes in air temperature are associated with an increase in cardiovascular events, but the role of procoagulant and proinflammatory blood markers is still poorly understood. The authors investigated the association between air temperature and fibrinogen, plasminogen activator inhibitor type 1, interleukin-6 and high-sensitivity C reactive protein in two potentially susceptible groups. Methods This prospective panel study was conducted between March 2007 and December 2008 in Augsburg, Germany. The study population comprised 187 participants with type 2 diabetes mellitus or impaired glucose tolerance and 87 participants with genetic polymorphisms on the detoxification and inflammation pathways. Overall, 1766 repeated blood measurements were collected. Hourly meteorology data were available from a central measurement site. The association between temperature and blood markers was analysed with additive mixed models. Results For type 2 diabetes mellitus and impaired glucose tolerance participants, the authors observed immediate, lagged and cumulative increases in fibrinogen (range of percentage changes in geometric mean: 0.6%e0.8%) and plasminogen activator inhibitor type 1 (6.0%e10.1%) in association with a 58C temperature decrement. Participants with a body mass index above 30 kg/m 2 as well as females showed particularly strong fibrinogen effects. In participants with the special genetic background, 58C decreases in the 5-day average of temperature led to a change of 8.0% (95% CI 0.5% to 16.2%) in interleukin-6 and of À8.4% (95% CI À15.8% to À0.3%) in high-sensitivity C reactive protein, the latter driven by physically active individuals. Conclusions The authors observed different temperature effects on blood markers in two potentially susceptible groups probably indicating varying underlying biological mechanisms. This study results might provide a link between temperature and cardiovascular events.

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Section: Discussionsupporting

confidence: 93%