Airborne Concentrations of Ethyl and Methyl Cyanoacrylate in the Workplace

Paustenbach, Dennis J.; Burke, Mary Lynn; Shum, Mona; Kalmes, Renee

doi:10.1080/15298660108984612

Cited by 3 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Industrial Hygiene Measurements The details of the industrial hygiene air sampling program and results are described elsewhere (Paustenbach et al, 1999). * There were few industrial hygiene samples for ECA and MCA collected at this site over the past 20 yr; however, the processes and equipment have not changed significantly since 1981 (the date of the commencement of the cohort follow-up).…”

Section: Data Collection Occupational Historiesmentioning

confidence: 99%

“…Therefore, the industrial hygiene sampling data collected in 1998 are believed to reflect the exposure of the cohort members throughout most of the past 19 yr. Adjustments to the exposure data were made as appropriate and are described in Paustenbach et al (1999). * The industrial hygiene study protocol included two types of sampling: (1) individual short-term sampling, with pumps worn by the employees involved in their usual work activities, and (2) area sampling, with pumps placed in representative work locations.…”

Section: Data Collection Occupational Historiesmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiologic Study of Pulmonary Obstruction in Workers Occupationally Exposed to Ethyl and Methyl Cyanoacrylate

Goodman

Paustenbach²,

Sipe³

et al. 2000

Journal of Toxicology and Environmental Health, Part A

View full text Add to dashboard Cite

The association between pulmonary obstruction (e.g., asthma) and occupational exposure to methyl cyanoacrylate (MCA) and ethyl cyanoacrylate (ECA) was examined in an occupational cohort of 450 persons at an adhesive production facility in Puerto Rico. Employee medical records containing information on physical examinations and pulmonary function tests (PFTs), as well as occupational histories, on each employee over a period of about 17 yr and industrial hygiene measurements were evaluated. The cohort analysis was based on a Cox proportional hazards model. Workers exposed to ECA or MCA were compared to workers unexposed to these chemicals with respect to their risk of becoming an "incident case." An "incident case" was defined as any person whose PFTs were normal at the time of employment, but later demonstrated an obstructive pattern, which was defined as a decline in the ratio of forced expiratory volume exhaled in 1 s to forced vital capacity (FEV1/FVC) below 70%. A separate case-control analysis was also conducted that compared "suspected cases," defined as all those whose PFTs ever demonstrated an obstructive pattern (e.g., asthma), to persons whose PFTs remained within normal limits throughout their employment with respect to their past peak and cumulative exposures to cyanoacrylates. All of these analyses showed no evidence that exposure to average short-term concentrations of ECA or MCA of less than 0.5 ppm and occasional daily peak exposures of at least 1.5 ppm (usually 10 min or less), with occasional higher concentrations during spills, were associated with an increased risk of pulmonary obstruction. However, the study suggested that persons occupationally exposed to cyanoacrylates were more likely to have some reversible eye or upper airway irritation than persons who were unexposed.

show abstract

Section: Data Collection Occupational Historiesmentioning

confidence: 99%

Section: Data Collection Occupational Historiesmentioning

confidence: 99%

Epidemiologic Study of Pulmonary Obstruction in Workers Occupationally Exposed to Ethyl and Methyl Cyanoacrylate

Goodman

Paustenbach²,

Sipe³

et al. 2000

Journal of Toxicology and Environmental Health, Part A

View full text Add to dashboard Cite

show abstract

Sensory Irritation due to Methyl-2-cyanoacrylate, Ethyl-2-cyanoacrylate, Isopropyl-2-cyanoacrylate and 2-Methoxyethyl-2-cyanoacrylate in Mice

Gagnaire

Marignac

Morel

et al. 2003

The Annals of Occupational Hygiene

View full text Add to dashboard Cite

The expiratory bradypnoea indicative of upper airway irritation in mice was evaluated during a period of 60 min of nasal exposure to methyl-2-cyanoacrylate, ethyl-2-cyanoacrylate, isopropyl-2-cyanoacrylate and 2-methoxyethyl-2-cyanoacrylate vapors using nose only exposure. Irritation of the upper respiratory tract caused a concentration-dependent decrease in the respiratory rate. The maximum effect occurred within the first 10 min of exposure and was followed by a drop-off in the response during the remainder of the exposure period. The airborne concentration resulting in a 50% decrease in the respiratory rate of mice (RD(50)) was calculated for each chemical. The results show that the four chemicals had similar irritant potencies. The RD(50) values of methyl-2-cyanoacrylate, ethyl-2-cyanoacrylate, isopropyl-2-cyanoacrylate and 2-methoxyethyl-2-cyanoacrylate were 1.4, 0.7, 0.6 and 1.0 p.p.m. Tentative estimates of threshold limit values showed that 0.1 RD(50) was closer to the values recommended by the American Conference of Governmental Industrial Hygienists for methyl- and ethyl-2-cyanoacrylate than 0.03 RD(50). On the basis of a threshold limit value for short-term exposure limit (TLV STEL) equal to 0.1 RD(50), the TLV STELs for the four cyanoacrylates should not exceed 0.1 or 0.2 p.p.m.

show abstract

Peak Inhalation Exposure Metrics Used in Occupational Epidemiologic and Exposure Studies

Virji

Kurth

2021

Front. Public Health

View full text Add to dashboard Cite

Peak exposures are of concern because they can potentially overwhelm normal defense mechanisms and induce adverse health effects. Metrics of peak exposure have been used in epidemiologic and exposure studies, but consensus is lacking on its definition. The relevant characteristics of peak exposure are dependent upon exposure patterns, biokinetics of exposure, and disease mechanisms. The objective of this review was to summarize the use of peak metrics in epidemiologic and exposure studies. A comprehensive search of Medline, Embase, Web of Science, and NIOSHTIC-2 databases was conducted using keywords related to peak exposures. The retrieved references were reviewed and selected for indexing if they included a peak metric and met additional criteria. Information on health outcomes and peak exposure metrics was extracted from each reference. A total of 1,215 epidemiologic or exposure references were identified, of which 182 were indexed and summarized. For the 72 epidemiologic studies, the health outcomes most frequently evaluated were: chronic respiratory effects, cancer and acute respiratory symptoms. Exposures were frequently assessed using task-based and full-shift time-integrated methods, qualitative methods, and real-time instruments. Peak exposure summary metrics included the presence or absence of a peak event, highest exposure intensity and frequency greater than a target. Peak metrics in the 110 exposure studies most frequently included highest exposure intensity, average short-duration intensity, and graphical presentation of the real-time data (plots). This review provides a framework for considering biologically relevant peak exposure metrics for epidemiologic and exposure studies to help inform risk assessment and exposure mitigation.

show abstract

Airborne Concentrations of Ethyl and Methyl Cyanoacrylate in the Workplace

Cited by 3 publications

References 16 publications

Epidemiologic Study of Pulmonary Obstruction in Workers Occupationally Exposed to Ethyl and Methyl Cyanoacrylate

Epidemiologic Study of Pulmonary Obstruction in Workers Occupationally Exposed to Ethyl and Methyl Cyanoacrylate

Sensory Irritation due to Methyl-2-cyanoacrylate, Ethyl-2-cyanoacrylate, Isopropyl-2-cyanoacrylate and 2-Methoxyethyl-2-cyanoacrylate in Mice

Peak Inhalation Exposure Metrics Used in Occupational Epidemiologic and Exposure Studies

Contact Info

Product

Resources

About