Airborne manganese exposure and neurobehavior in school-aged children living near a ferro-manganese alloy plant

Rodrigues, Juliana Lima Gomes; Araújo, Cecília F.S.; Santos, Nathália R. dos; Bandeira, Matheus J.; Anjos, Ana Laura S; Carvalho, Chrissie Ferreira de; Santos-Lima, Cassio; Abreu, Neander; Mergler, Donna; Menezes-Filho, José A.

doi:10.1016/j.envres.2018.07.007

Cited by 56 publications

(35 citation statements)

References 61 publications

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“…A study assessing Mn accumulation in children aged 7-12 years and living near a ferro-manganese alloy plant indicated toenail Mn as a biomarker of environmental exposure, associating the burden of this metal in exposed subjects with disrupting neurobehavior. Of note, in exposed children, the median Mn toenail concentration recorded in the cited study was about 5 times lower than the mean value (0.84 µg/g) observed in our study [50].…”

Section: Discussioncontrasting

confidence: 81%

“…Toenail concentration of Mn has been frequently studied both in children [47][48][49][50] and in adults [40], with an LOD ranging from 0.001 [81] to 0.33 µg/g [66] and values usually below 10 µg/g [40]. The highest Mn toenail concentrations have been found in subjects living near a highly industrialized city in Pakistan (average value 52.1 µg/g) [82] and in highly polluted areas in Cambodia (average concentration 43.9 µg/g) [66].…”

Section: Discussionmentioning

confidence: 99%

“…In fact, human biomonitoring has been proposed as more useful to assess possible health effects than environmental monitoring [44,45]. In this respect, human nails have been frequently employed for the assessment of metal exposure of various origin [46], have been used in pediatric age [47][48][49][50][51], and have been indicated as suitable indicators of long-term exposures [52,53].…”

Section: Introductionmentioning

confidence: 99%

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Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Ciaula

Gentilini²,

Diella

et al. 2020

IJERPH

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The impact of waste incinerators is usually examined by measuring environmental pollutants. Biomonitoring has been limited, until now, to few metals and to adults. We explored accumulation of a comprehensive panel of metals in children free-living in an urban area hosting two waste incinerators. Children were divided by georeferentiation in exposed and control groups, and toenail concentrations of 23 metals were thereafter assessed. The percentage of children having toenail metal concentrations above the limit of detection was higher in exposed children than in controls for Al, Ba, Mn, Cu, and V. Exposed children had higher absolute concentrations of Ba, Mn, Cu, and V, as compared with those living in the reference area. The Tobit regression identified living in the exposed area as a significant predictor of Ba, Ni, Cu, Mn, and V concentrations, after adjusting for covariates. The concentrations of Ba, Mn, Ni, and Cu correlated with each other, suggesting a possible common source of emission. Exposure to emissions derived from waste incinerators in an urban setting can lead to body accumulation of specific metals in children. Toenail metal concentration should be considered a noninvasive and adequate biomonitoring tool and an early warning indicator which should integrate the environmental monitoring of pollutants.

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Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Ciaula

Gentilini²,

Diella

et al. 2020

IJERPH

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“…Manganese ferroalloys are metal mixtures primarily composed of iron (Fe) in combination with manganese (Mn) and other metals such as chromium (Cr), lead (Pb), copper (Cu), nickel (Ni), zinc (Zn), cadmium (Cd), and aluminum (Al) (Olsen et al 2007). Most environmental epidemiology studies in communities living near ferromanganese industries have focused on Mn only, reporting associations with parkinsonism in adults and neurobehavioral decrements in children and the elderly, such as worse overall cognition, behavior, attention, learning and memory, olfactory function, and motor abilities (Bauer et al 2017;Chiu et al 2017;Haynes et al 2015;Lucchini et al 2007Lucchini et al , 2014Menezes-Filho et al 2014;Rodrigues et al 2018). Yet other metals in the ferroalloy mixture, such as Pb and Cu, are also known to be neurotoxic (Bulcke et al 2017;Caito and Aschner 2017).…”

Section: Introductionmentioning

confidence: 99%

Associations of a Metal Mixture Measured in Multiple Biomarkers with IQ: Evidence from Italian Adolescents Living near Ferroalloy Industry

Bauer

Devick

Bobb

et al. 2020

Environ Health Perspect

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BACKGROUND: Research on the health effects of chemical mixtures has focused mainly on early life rather than adolescence, a potentially important developmental life stage. OBJECTIVES: We examined associations of a metal mixture with general cognition in a cross-sectional study of adolescents residing near ferromanganese industry, a source of airborne metals emissions. METHODS: We measured manganese (Mn), lead (Pb), copper (Cu), and chromium (Cr) in hair, blood, urine, nails, and saliva from 635 Italian adolescents 10-14 years of age. Full-scale, verbal, and performance intelligence quotient (FSIQ, VIQ, PIQ) scores were assessed using the Wechsler Intelligence Scale for Children-III. Multivariable linear regression and Bayesian kernel machine regression (BKMR) were used to estimate associations of the metal mixture with IQ. In secondary analyses, we used BKMR's hierarchical variable selection option to inform biomarker selection for Mn, Cu, and Cr. RESULTS: Median metal concentrations were as follows: hair Mn, 0:08 lg=g; hair Cu, 9:6 lg=g; hair Cr, 0:05 lg=g; and blood Pb, 1:3 lg=dL. Adjusted models revealed an inverted U-shaped association between hair Cu and VIQ, consistent with Cu as an essential nutrient that is neurotoxic in excess. At low levels of hair Cu (10th percentile, 5:4 lg=g), higher concentrations (90th percentiles) of the mixture of Mn, Pb, and Cr (0:3 lg=g, 2:6 lg=dL, and 0:1 lg=g, respectively) were associated with a 2.9 (95% CI: −5:2, −0:5)-point decrease in VIQ score, compared with median concentrations of the mixture. There was suggestive evidence of interaction between Mn and Cu. In secondary analyses, saliva Mn, hair Cu, and saliva Cr were selected as the biomarkers most strongly associated with VIQ score. DISCUSSION: Higher adolescent levels of Mn, Pb, and Cr were associated with lower IQ scores, especially at low Cu levels. Findings also support further investigation into Cu as both beneficial and toxic for neurobehavioral outcomes.

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“…Estos resultados servirán como punto de referencia para evaluar variaciones futuras en el contenido de Mn en la Ciudad de México. S cientific concern about the contamination due to manganese (Mn) has been raised because of its increasing presence in the environment, related to anthropogenic sources such as mining and smelting, 1 Mn alloy production, 2,3 welding, dry alkaline battery manufacturing, Mn salt production, ceramics, glass, aluminum cans and electronic components manufacture, 4 agrochemicals containing Mn such as fungicides and fertilizers, 5 as well as vehicle emissions. 6 The phasing out of lead compounds from gasoline has led to the use of other compounds that have antiknock characteristics, such as the methylcyclopentadienyl manganese tricarbonyl (MMT).…”

Section: Introductionmentioning

confidence: 99%

Spatial distribution of manganese concentration and load in street dust in Mexico City

et al. 2020

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Objective. To obtain a first indication of the distribution and extent of manganese (Mn) contamination in Mexico City. Mn concentration and load in street dust were analyzed in order to reveal the most contaminated areas. Materials and methods. 482 samples of street dust were analyzed through inductively coupled plasma-optical emission spectroscopy. The contamination factor (CF), the geoaccumulation index (Igeo) and the spatial interpolations of the kriging indicator were calculated. Results. A slight influence of anthropogenic activities is detected on the Mn content of street dust. The highest levels of pollution by concentration (Igeo=uncontaminated to moderately contaminated) are grouped towards the city’s north (industrial) and center (commercial and high traffic) areas. The areas with the highest Mn load were located towards the east and northwest areas (Igeo=moderately contaminated). Conclusions. These findings will serve as a baseline to assess future variations in Mn content in Mexico City’s environment.

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Airborne manganese exposure and neurobehavior in school-aged children living near a ferro-manganese alloy plant

Cited by 56 publications

References 61 publications

Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Biomonitoring of Metals in Children Living in an Urban Area and Close to Waste Incinerators

Associations of a Metal Mixture Measured in Multiple Biomarkers with IQ: Evidence from Italian Adolescents Living near Ferroalloy Industry

Spatial distribution of manganese concentration and load in street dust in Mexico City

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