Airborne outbreak of nosocomial Scedosporium prolificans infection

Guerrero, Antonio; Torres, Pio; Durán, María Teresa; Ruiz‐Díez, Beatriz; Rosales, Miguel A.; Rodríguez-Tudela, Juan Luis

doi:10.1016/s0140-6736(00)04423-8

Cited by 53 publications

(38 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For all 3 Scedosporium spp., there was no clustering of strains according to their geographic or body site of origin or by their ability to cause invasive disease, which is in agreement with previous fi ndings for S. apiospermum (20,30) and S. prolifi cans (16,17,21). Of note, no specifi c genotypes were associated with underlying medical conditions or risk factors.…”

Section: Discussionsupporting

confidence: 91%

“…These fi ndings exclude the occurrence of nosocomial outbreaks or any close relationship with the nonoutbreak isolates, a result similar to those obtained previously (38). Overall nosocomial acquisition of infection has been demonstrated in only 2 instances (16,17). Scedosporium spp.…”

Section: Discussionsupporting

confidence: 86%

“…S. prolifi cans infections are geographically more restricted than those caused by S. apiospermum, being most prevalent in Australia, Spain, and the United States (12)(13)(14)(15). S. prolifi cans typically causes localized infections in immunocompetent hosts but rapidly fatal disseminated infections in the immunocompromised among whom it has been associated with nosocomial outbreaks (3,(12)(13)(14)(15)(16)(17).…”

Section: Molecular Typing Of Australian Scedosporium Isolates Showingmentioning

confidence: 99%

See 2 more Smart Citations

Molecular Typing of AustralianScedosporiumIsolates Showing Genetic Variability and NumerousS. aurantiacum

Delhaès

Harun

Chen

et al. 2008

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 86%

Section: Molecular Typing Of Australian Scedosporium Isolates Showingmentioning

confidence: 99%

See 1 more Smart Citation

Molecular Typing of AustralianScedosporiumIsolates Showing Genetic Variability and NumerousS. aurantiacum

Delhaès

Harun

Chen

et al. 2008

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

“…The overall frequency of Scedosporium infections is relatively low in most geographic areas; however, hospital-based clusters in patients with hematological malignancies have been described (11,173,368,474). Although there have been several nosocomial outbreaks, hospital environmental sampling has been less than helpful in determining a specific source of infection despite the use of selective media for isolation (11,35).…”

Section: Environmental Epidemiologymentioning

confidence: 99%

Infections Caused byScedosporiumspp

et al. 2008

View full text Add to dashboard Cite

SUMMARY Scedosporium spp. are increasingly recognized as causes of resistant life-threatening infections in immunocompromised patients. Scedosporium spp. also cause a wide spectrum of conditions, including mycetoma, saprobic involvement and colonization of the airways, sinopulmonary infections, extrapulmonary localized infections, and disseminated infections. Invasive scedosporium infections are also associated with central nervous infection following near-drowning accidents. The most common sites of infection are the lungs, sinuses, bones, joints, eyes, and brain. Scedosporium apiospermum and Scedosporium prolificans are the two principal medically important species of this genus. Pseudallescheria boydii, the teleomorph of S. apiospermum, is recognized by the presence of cleistothecia. Recent advances in molecular taxonomy have advanced the understanding of the genus Scedosporium and have demonstrated a wider range of species than heretofore recognized. Studies of the pathogenesis of and immune response to Scedosporium spp. underscore the importance of innate host defenses in protection against these organisms. Microbiological diagnosis of Scedosporium spp. currently depends upon culture and morphological characterization. Molecular tools for clinical microbiological detection of Scedosporium spp. are currently investigational. Infections caused by S. apiospermum and P. boydii in patients and animals may respond to antifungal triazoles. By comparison, infections caused by S. prolificans seldom respond to medical therapy alone. Surgery and reversal of immunosuppression may be the only effective therapeutic options for infections caused by S. prolificans.

show abstract

“…Clinical discussion (see Clinical Syndromes and Their Management below) will be limited to S. prolificans, as related species have been extensively reviewed elsewhere (153) and may not reveal phaeoid hyphae in tissue, in contrast to the case for S. prolificans. Infection with this organism is of major concern in all settings due to its refractoriness to antifungal therapy and associated high mortality (18,29,76,96,119,153,312,475,538,664,802,806). A recent review of 162 cases reported in the literature summarizes major risk factors as malignancy (46%), cystic fibrosis (12%), and solid organ transplantation (9%) and chief clinical presentations as disseminated infection (44%) and pulmonary mycoses (29%), followed by bone and joint infections (10%) (638).…”

Section: Microascalesmentioning

confidence: 99%

Melanized Fungi in Human Disease

2010

View full text Add to dashboard Cite

SUMMARY Melanized or dematiaceous fungi are associated with a wide variety of infectious syndromes. Many are soil organisms and are generally distributed worldwide, though certain species appear to have restricted geographic ranges. Though they are uncommon causes of disease, melanized fungi have been increasingly recognized as important pathogens, with most reports occurring in the past 20 years. The spectrum of diseases with which they are associated has also broadened and includes allergic disease, superficial and deep local infections, pneumonia, brain abscess, and disseminated infection. For some infections in immunocompetent individuals, such as allergic fungal sinusitis and brain abscess, they are among the most common etiologic fungi. Melanin is a likely virulence factor for these fungi. Diagnosis relies on careful microscopic and pathological examination, as well as clinical assessment of the patient, as these fungi are often considered contaminants. Therapy varies depending upon the clinical syndrome. Local infection may be cured with excision alone, while systemic disease is often refractory to therapy. Triazoles such as voriconazole, posaconazole, and itraconazole have the most consistent in vitro activity. Further studies are needed to better understand the pathogenesis and optimal treatment of these uncommon infections.

show abstract

Airborne outbreak of nosocomial Scedosporium prolificans infection

Cited by 53 publications

References 4 publications

Molecular Typing of AustralianScedosporiumIsolates Showing Genetic Variability and NumerousS. aurantiacum

Molecular Typing of AustralianScedosporiumIsolates Showing Genetic Variability and NumerousS. aurantiacum

Infections Caused byScedosporiumspp

Melanized Fungi in Human Disease

Contact Info

Product

Resources

About