Airborne silica levels in an urban area

Berardis, Barbara De; Incocciati, Emma; Massera, S; Gargaro, G.; Paoletti, L.

doi:10.1016/j.scitotenv.2007.04.044

Cited by 17 publications

(6 citation statements)

References 22 publications

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“…However, the population-attributable fractions may actually be smaller than 1.00, considering that some burden of pneumoconiosis may be caused by residential exposure to one or more sources of asbestos (Tarres et al, 2013), silica and coal dust (Akaoka et al, 2017) among residents near mines; non-occupational exposure to silica from the natural environment (e.g. in deserts or from sand storms) (De Berardis et al, 2007) and from second-hand exposures (e.g. family members of exposed workers coming into contact with contaminated clothes etc.…”

Section: Rationalementioning

confidence: 99%

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to dusts and/or fibres and of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis

Mandrioli

Schlünssen

Ádám

et al. 2018

Environment International

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Section: Rationalementioning

confidence: 99%

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of occupational exposure to dusts and/or fibres and of the effect of occupational exposure to dusts and/or fibres on pneumoconiosis

Mandrioli

Schlünssen

Ádám

et al. 2018

Environment International

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“…Studies conducted in diff erent urban areas of the USA (Davis et al, 1984) and in Italy (Puledda et al, 1999;De Berardis et al, 2007) (Rome) found crystalline silica levels in the PM10 range. In vitro (Balduzzi et al, 2004;Fanizza et al, 2007) and in vivo (Porter et al, 2002) studies demonstrated that aged fractured quartz also may exert adverse eff ects.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of cytotoxic concentration–time response in A549 cells exposed to respirable α‐quartz

Fanizza¹,

Fresegna

Maiello

et al. 2009

J of Applied Toxicology

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A causal pathway between quartz, silicosis and lung cancer has been postulated. The aim of our study was to assess cytotoxic effects induced in a human lung epithelial cell line (A549) by exposure to alpha-quartz. Cells were exposed to respirable alpha-quartz (SRM1878a, NIST) at 25, 50 or 100 microg ml(-1 )for 24 h and at 50 or 100 microg ml(-1) for 48 h. Cytotoxic effects were analyzed by scanning electron microscopy (SEM), apoptotic morphology analysis with Hoechst staining and lactate dehydrogenase (LDH) release assay. In cells exposed to alpha-quartz for 24 h, a concentration-dependent bleb development and in particular the localization of blebs at the cell edge at higher concentrations were observed. The blebbing phenomenon was more evident after 48 h of exposure to 50 or to 100 microg ml(-1) of alpha-quartz and large blebs were localized at the cell edge. At the same concentrations surface smoothing was also observed. Moreover the presence of holes and tears was detected at the highest concentration both at 24 and 48 h. Results of morphological analysis with Hoechst stain evidenced an increase concentration-time dependent of apoptotic cell percentage that was more marked after 48 h exposure to 100 microg ml(-1) and a prevalence of late apoptosis stage with the increase of exposure time and concentration. Cells exposed to 50 or 100 microg ml(-1) of alpha-quartz for 24 and 48 h produced a significant increase in LDH release. The concentration-time-dependent bleb induction evidenced by SEM correlates with the increase of apoptotic cells and LDH activity release, demonstrating the onset of cytotoxic effects in human lung cells exposed to alpha-quartz.

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“…1,2 Volcanoes are a major source of natural silica, and 9% of the world's population lives within 100 km of historically active volcanos. environmental exposure to ambient crystalline silica can occur during natural, agricultural, or industrial activities.…”

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confidence: 99%