This chapter summarizes the work done at the Airliner Cabin Environment Research Lab (ACERL) related to air quality, airflow characteristics, and human thermal comfort inside aircraft cabins. The laboratory is part of the Institute for Environmental Research (IER) at Kansas State University. It has a Boing 767 mockup cabin, bleed air simulator, and a Boeing 737 actual aircraft section that were all utilized to conduct experimental studies to understand air quality inside aircraft cabins. The studies summarized in this chapter include particle image velocimetry (PIV) investigations, particle dispersion, computational fluid dynamics (CFD) simulations, tracer gas and smoke visualization studies, and bleed air investigations. The chapter also summarizes other related studies including virus dispersion, air quality monitoring devices, and related developed air quality standards. The scope of this chapter is to summarize the setup and results of each of the above categories. This summary along with the cited references provides results for full size aircraft cabin environments, helps validate data for CFD simulations, and provides comparison data for other similar studies. This helps improve the design of future aircraft cabins and their ventilation systems and recommends changes to maintenance practices done that can improve the health and safety of humans inside these enclosed compartments.