Aire's partnerships: An answer for many questions and new questions in search of answers

Towns, Roberto; Pietropaolo, Massimo

doi:10.1111/j.1399-5448.2010.00652.x

Pediatric Diabetes

2010

DOI: 10.1111/j.1399-5448.2010.00652.x

|View full text |Cite

Aire's partnerships: An answer for many questions and new questions in search of answers

Roberto Towns

Massimo Pietropaolo

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2014

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The biophysical and biochemical properties of the autoimmune regulator (AIRE) protein

Perniola

Musco

2014

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

View full text Add to dashboard Cite

AIRE (for autoimmune regulator) is a multidomain protein that performs a fundamental function in the thymus and possibly in the secondary lymphoid organs: the regulation, especially in the sense of activation, of the process of gene transcription in cell lines deputed to the presentation of self-antigens to the maturing T lymphocytes. The apoptosis of the elements bearing T-cell receptors with critical affinity for the exhibited self-antigens prevents the escape of autoreactive clones and represents a simple and efficient mechanism of deletional self-tolerance. However, AIRE action relies on an articulated complex of biophysical and biochemical properties, in most cases attributable to single subspecialized domains. Here a thorough review of the matter is presented, with a privileged look at the pathogenic changes of AIRE that interfere with such properties and lead to the impairment in its chief function.

show abstract

The biophysical and biochemical properties of the autoimmune regulator (AIRE) protein

Perniola

Musco

2014

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Aire's partnerships: An answer for many questions and new questions in search of answers

Cited by 1 publication

References 17 publications

The biophysical and biochemical properties of the autoimmune regulator (AIRE) protein

The biophysical and biochemical properties of the autoimmune regulator (AIRE) protein

Contact Info

Product

Resources

About