Analyzing
trace-level volatile organic compounds (VOCs)
remains
challenging due to initial sampling and preconcentration limitations.
Inspired by the highly reproducible and constantly renewable electrode
surface of dropping mercury electrode (DME), a contactless enrichment
process was first reported by using an acoustic levitation device
to trap and concentrate VOCs from gas samples onto suspended droplets,
which were then directly transferred into gas chromatography–mass
spectrometry (GC-MS) for real-time analysis. Compared with traditional
methods injection methods, this method achieves a 46-fold increase
in nicotine peak area. The detection sensitivity was enhanced significantly,
attributed to the high specific surface area of the droplets and the
accelerating extraction vibration. Notably, the number of identified
VOCs from burning cigarettes significantly increased from 17 to 212,
including 22 aromatic compounds with distinct aromas. The remarkable
versatility of this method was demonstrated by effectively monitoring
the dynamic changes of 16 VOCs in environmental tobacco smoke (ETS)
following cigarette burning, revealing the persistence of these compounds,
even after 40 min. Moreover, directly analyzing human-exhaled aerosol
found that nicotine rapidly decreased while its metabolite cotinine
increased, showcasing the potential for tracking human metabolism
and behavior in vivo. Furthermore, multivariate data analysis of VOC
profiles from six cigarette brands allowed for their visual differentiation.
With versatility, sensitivity, and the ability to distinguish trace-level
VOCs in realtime, this method offers promising avenues for environmental
monitoring, metabolic studies, and various analytical applications.