Airway calibre variation is a major determinant of exhaled nitric oxide's ability to capture asthma control

Michils, Alain; Haccuria, Amaryllis; Michiels, Sébastien; Muylem, Alain Van

doi:10.1183/13993003.00392-2017

Cited by 9 publications

(4 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A large part of FeNO is produced in the peripheral airways and therefore FeNO might paradoxically decrease if the small airway caliber reduces despite no changes in airway inflammation 8 . Thus, we speculate that the decrease in FeNO in the high FeNO group might be induced by small airway narrowing as reflected by the increase in R5 and R5‐R20 in this study.…”

Section: Figurementioning

confidence: 65%

High fractional exhaled nitric oxide levels may predict short‐term worsening of respiratory oscillometry in asthma

Endo

Shirai

Hirai

et al. 2020

Allergy

View full text Add to dashboard Cite

Section: Figurementioning

confidence: 65%

High fractional exhaled nitric oxide levels may predict short‐term worsening of respiratory oscillometry in asthma

Endo

Shirai

Hirai

et al. 2020

Allergy

View full text Add to dashboard Cite

“…Soto-Ramos et al found that patients with well-controlled asthma had lower FeNO levels [16] . However, Michils et al found that changes in asthma symptoms did not coincide with changes in pulmonary function and FeNO [17] . Our study found that FeNO levels differed according to the level of asthma control, with the highest level in the poor control group and a gradual decrease with improvement in asthma control.…”

Section: Discussionmentioning

confidence: 98%

Application of fractional exhaled nitric oxide and nasal nitric oxide in the evaluation of asthma control

Ma,

Lin,

Zheng

et al. 2023

Preprint

View full text Add to dashboard Cite

Background Asthma is the most common chronic respiratory disease in childhood. Persistent chronic airway inflammation is a pathological feature of asthma, so the control of airway inflammation is particularly important in asthma treatment. In recent years, fractional exhaled nitric oxide (FeNO) and fractional nasally exhaled nitric oxide (FnNO) has been used in the evaluation of airway inflammation. Methods This was a retrospective study. This study retrospectively analyzed the clinical data of 88 patients with asthma who received treatment and follow-up at The First Hospital of Jilin University from 2019 to 2022. The inclusion criteria were as follows: a. all patients met the criteria for diagnosis of bronchial asthma14; b. chronic persistent asthma was treated with standard protocols for more than 3 months; and c. the patient was able to cooperate with lung ventilation function tests and FeNO and FnNO examination.All subjects were divided into a control group, a partial control group and a poor control group according to Childhood Asthma Control Test (C-ACT) scores. FeNO, FnNO, and pulmonary function were compared among the three groups. We also analyzed whether FeNO and FnNO were correlated with various indices of pulmonary function in patients with asthma. Results The level of asthma control was not affected by rhinitis attacks. The FeNO and FnNO values of the poor control group were significantly higher than those of the partial control group and the control group. As asthma control improved, forced vital capacity (FVC) showed a statistically significant increase. The FEV1, maximal expiratory flow at 50% of the FVC (MEF50%) and maximal midexpiratory flow (MMEF) levels in the poor control group were significantly lower than those in the partial control group and the control group, and the PEF level of the poor control group was significantly lower than that of the control group. FeNO and FnNO had no significant correlation with pulmonary function parameters. Conclusions FeNO and FnNO should be used to assess the level of control in patients with asthma. There is no significant correlation among FeNO, FnNO and various parameters of pulmonary function.

show abstract

“…The performance of FE NO as a biomarker of asthma control increases when its assessment is combined with lung function parameters [122][123], when it is used to predict the future risk of losing asthma control [124][125][126][127][128], or when its increase in a given time is considered as a marker of loss of asthma control [119].…”

Section: Fe No and Asthma Controlmentioning

confidence: 99%

Fractional Exhaled Nitric Oxide (FENO) in the management of asthma: a position paper of the Italian Respiratory Society (SIP/IRS) and Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC)

Heffler¹,

Carpagnano

Favero

et al. 2020

Multidis Res Med

View full text Add to dashboard Cite

Asthma prevalence in Italy is on the rise and is estimated to be over 6% of the general population. The diagnosis of asthma can be challenging and elusive, especially in children and the last two decades has brought evidences that asthma is not a single disease but consists of various phenotypes. Symptoms can be underestimated by the patient or underreported to the clinician and physical signs can be scanty. Usual objective measures, like spirometry, are necessary but sometimes not significant. Despite proper treatment asthma can be a very severe condition (even leading to death) however new drugs have recently become available which can be very effective in its control. Since asthma is currently thought to be caused by inflammation, a direct measure of the latter can be of paramount importance. For this purpose, the measurement of Fractional Exhaled Nitric Oxide (FENO) has been used since the early years of the current century as a non-invasive, easy-to-assess tool useful for diagnosing and managing asthma. This SIP-IRS/SIAAIC Position Paper is a narrative review which summarizes the evidence behind the usefulness of FENO in the diagnosis, management and phenotypization of asthma.

show abstract

Airway calibre variation is a major determinant of exhaled nitric oxide's ability to capture asthma control

Cited by 9 publications

References 33 publications

High fractional exhaled nitric oxide levels may predict short‐term worsening of respiratory oscillometry in asthma

High fractional exhaled nitric oxide levels may predict short‐term worsening of respiratory oscillometry in asthma

Application of fractional exhaled nitric oxide and nasal nitric oxide in the evaluation of asthma control

Fractional Exhaled Nitric Oxide (FENO) in the management of asthma: a position paper of the Italian Respiratory Society (SIP/IRS) and Italian Society of Allergy, Asthma and Clinical Immunology (SIAAIC)

Contact Info

Product

Resources

About