Airway Complications from an Esophageal Foreign Body

García, Ismael; Varon, Joseph; Surani, Salim

doi:10.1155/2016/3403952

Cited by 7 publications

(6 citation statements)

References 21 publications

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“…Several novel causal links are founded and supported by clinical case report or observational studies. For example, for C16 Malignant neoplasm of stomach, Urate [52], T17 Foreign body in respiratory tract [53-54], F31 Bipolar affective disorder [55] and K41 Femoral hernia [56] have negative causal effects on the Malignant neoplasm of stomach. Urate [57] positively affects the risk of Carcinoma in situ of skin.…”

Section: Resultsmentioning

confidence: 99%

MRSL: A phenome-wide causal discovery algorithm based on GWAS summary data

Hou

Geng

Shi

et al. 2022

Preprint

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Causal discovery is a powerful tool to disclose underlying structures by analyzing purely observational data. Genetic variants can provide useful complementary information for structure learning. Here, we propose a novel algorithm MRSL (Mendelian Randomization (MR)-based Structure Learning algorithm), which combines the graph theory with univariable and multivariable MR to learn the true structure using only GWAS summary statistics. Specifically, MRSL also utilizes topological sorting to improve the precision of structure learning and provides three adjusting categories for multivariable MR. Results of simulation reveal that MRSL has up to two-fold higher F1 score than other eight competitive methods. Additionally, the computing time of MRSL is 100 times faster than other methods. Furthermore, we apply MRSL to 26 biomarkers and 44 ICD10-defined diseases from UK Biobank. The results cover most of expected causal links which have biological interpretations and several new links supported by clinical case reports or previous observational literatures.

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Section: Resultsmentioning

confidence: 99%

MRSL: A phenome-wide causal discovery algorithm based on GWAS summary data

Hou

Geng

Shi

et al. 2022

Preprint

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“…Approximately 10% of patients with esophageal foreign bodies have symptoms of airway involvement (18). The airway symptoms can stem from extrinsic compression of the membranous wall of the trachea or perforation of the esophagus and trachea by sharp objects (19,20). Patients with airway involvement represent more complicated cases of FBI and can, therefore, be expected to have a longer LOS for airway procedures and careful observation after removal of the foreign body.…”

Section: Discussionmentioning

confidence: 99%

Inpatient Pediatric Foreign Body Ingestion

Wood¹,

Potnuru

Nair³

2021

J. pediatr. gastroenterol. nutr.

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Objective: We generated national estimates of patient and hospitalization characteristics for pediatric inpatient admissions for foreign body ingestion (FBI) and compared these to admissions for other reasons. We further identified characteristics that were independently associated with length of stay (LOS). Finally, we hypothesized that endoscopy within 24 hours of admission was independently associated with a shorter LOS in patients admitted for FBI. Methods: In this retrospective study, we used data from the Kids' Inpatient Database for 2016. Admissions for FBI were identified and national estimates of patient and hospitalization characteristics were generated. Patients admitted for FBI were compared to patients admitted for other causes. Data were analyzed for independent associations with LOS. Subgroup analysis was performed to determine whether early endoscopy was associated with a shorter LOS. Results: A total of 2464 admissions for FBI were identified in the database. The median (interquartile range) patient age was 4 (1-11) years with a slight male predominance. Most patients (82.6%) had an endoscopy performed during admission. Independent factors associated with increased LOS included: airway procedures, intra-abdominal surgery, psychiatric diagnosis, esophageal disorder, and developmental delay. Among patients who required endoscopy, 56.7% were performed early (within 24 hours). Early endoscopy was independently associated with a 35% shorter LOS (incidence rate ratio ¼ 0.65, 95% confidence interval 0.54-0.80; P¼0.009). Conclusions: Inpatient admissions for FBI frequently require endoscopy and have a short LOS. In patients who require endoscopy during the admission, early endoscopy (within 24 hours of admission) may be associated with a shorter LOS.

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“…2,4 In children, organic EFBI is often secondary to an underlying esophageal pathology such as EoE, postanastomotic stricture after tracheoesophageal fistula repair, rings, webs, diverticula, achalasia, or other motility disorders. 3,5,6,[23][24][25][26] Although the risk of complication from EFBI is low as 90% of cases resolve spontaneously, 10% to 20% will require endoscopic intervention, 27 as there have been case reports of severe complications with food impactions such as airway compromise leading to hypoxemia 28 and death from perforation and haemorrhage. 29 3 The use of MD should not preclude the use of endoscopy as there is often an underlying pathology, 3,5,6,[23][24][25][26] as demonstrated in our study where 47.5% of patients who underwent endoscopy had abnormal histological findings; however, if there is symptomatic relief with MD, the procedure can be performed electively as an outpatient, reducing the need for an emergency procedure.…”

Section: Discussionmentioning

confidence: 99%

“…In children, organic EFBI is often secondary to an underlying esophageal pathology such as EoE, postanastomotic stricture after tracheoesophageal fistula repair, rings, webs, diverticula, achalasia, or other motility disorders 3,5,6,23–26 . Although the risk of complication from EFBI is low as 90% of cases resolve spontaneously, 10% to 20% will require endoscopic intervention, 27 as there have been case reports of severe complications with food impactions such as airway compromise leading to hypoxemia 28 and death from perforation and haemorrhage 29 …”

Section: Discussionmentioning

confidence: 99%

Medical Disimpaction for Children With Organic Esophageal Foreign Body in the Era of Eosinophilic Esophagitis

Lee

Grover²,

Borland³

et al. 2018

Pediatr Emer Care

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Objective: Esophageal foreign body impaction (EFBI) is a common presentation in pediatric emergency medicine. Interventions (medical or endoscopic) are often required because of the severity of symptoms and risk of complications. Use of medical disimpaction (MD) such as glucagon injections and effervescent agents (eg, carbonated beverages) has been well described in adults; however, there are limited data in the pediatric literature. Eosinophilic esophagitis (EoE) is a relatively "new" clinicopathological entity that may present with EFBI mostly due to food with histological findings of EoE. Our study aim was to determine the efficacy of MD for organic EFBI in the pediatric population especially in children with EoE.Methods: A retrospective chart review was performed using the International Classification of Diseases codes and the emergency department database of patients presenting with EFBI from January 2010 to December 2014. Response to MD was defined as symptomatic relief of obstruction. Age, object ingested, medical agent used, EoE status, complications, and outcome were recorded.Results: A total of 317 presentations of EFBI were identified during the study period, of which organic EFBI accounted for 101 impactions (31.9%). Medical disimpaction was attempted for 42 (41.6%) with organic EFBI, resulting in resolution of symptoms for 16 (38.1%). One child with EoE responded to MD compared with 15 without EoE (4.8% vs 71.4%, P < 0.0001). Conclusions: Medical disimpaction was ineffective in children with EoEbut may be of help with symptom resolution in approximately 70% of children without EoE.

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Airway Complications from an Esophageal Foreign Body

Cited by 7 publications

References 21 publications

MRSL: A phenome-wide causal discovery algorithm based on GWAS summary data

MRSL: A phenome-wide causal discovery algorithm based on GWAS summary data

Inpatient Pediatric Foreign Body Ingestion

Medical Disimpaction for Children With Organic Esophageal Foreign Body in the Era of Eosinophilic Esophagitis

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