Airway delivery of <scp><i>Streptococcus salivarius</i></scp> is sufficient to induce experimental pulmonary hypertension in rats

Zhang, Chenting; Zhang, Tingting; Xing, Yue; Lu, Wenju; Chen, Jiyuan; Luo, Xiaoning; Wu, Xiaoqian; Liu, Shiyun; Chen, Lishi; Zhang, Zizhou; Zhou, Dansha; Lin, Ziying; Chen, Yuqin; Xiong, Mingmei; Yuan, Jason X.‐J.; Yang, Kai; Wang, Jian

doi:10.1111/bph.16064

Cited by 3 publications

(1 citation statement)

References 40 publications

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“…Exposure to Streptococcus salivarius resulted in increased right ventricular systolic pressure, right ventricular hypertrophy, and pulmonary vascular remodeling, all typical characteristics of PH. S. salivarius ‐induced PH was characterized by increased inflammation in the lung and was also associated with a shift in the gut microbiome composition, indicating potential communication between the lung and gut axis [ 109 ]. Overall, the specific impact of changes in lung microbiota on gut function is still poorly characterized and needs further research efforts.…”

Section: Gut–lung Axismentioning

confidence: 99%

Promising dawn in the management of pulmonary hypertension: The mystery veil of gut microbiota

Yang,

Zhang,

Wang

et al. 2024

iMeta

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The gut microbiota is a complex community of microorganisms inhabiting the intestinal tract, which plays a vital role in human health. It is intricately involved in the metabolism, and it also affects diverse physiological processes. The gut–lung axis is a bidirectional pathway between the gastrointestinal tract and the lungs. Recent research has shown that the gut microbiome plays a crucial role in immune response regulation in the lungs and the development of lung diseases. In this review, we present the interrelated factors concerning gut microbiota and the associated metabolites in pulmonary hypertension (PH), a lethal disease characterized by elevated pulmonary vascular pressure and resistance. Our research team explored the role of gut‐microbiota‐derived metabolites in cardiovascular diseases and established the correlation between metabolites such as putrescine, succinate, trimethylamine N‐oxide (TMAO), and N, N, N‐trimethyl‐5‐aminovaleric acid with the diseases. Furthermore, we found that specific metabolites, such as TMAO and betaine, have significant clinical value in PH, suggesting their potential as biomarkers in disease management. In detailing the interplay between the gut microbiota, their metabolites, and PH, we underscored the potential therapeutic approaches modulating this microbiota. Ultimately, we endeavor to alleviate the substantial socioeconomic burden associated with this disease. This review presents a unique exploratory analysis of the link between gut microbiota and PH, intending to propel further investigations in the gut–lung axis.

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Section: Gut–lung Axismentioning

confidence: 99%

Promising dawn in the management of pulmonary hypertension: The mystery veil of gut microbiota

Yang,

Zhang,

Wang

et al. 2024

iMeta

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Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+ T cell infiltration in mice

Meng,

Du,

et al. 2024

Int J Oral Sci

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Uncovering the risk factors of pulmonary hypertension and its mechanisms is crucial for the prevention and treatment of the disease. In the current study, we showed that experimental periodontitis, which was established by ligation of molars followed by orally smearing subgingival plaques from patients with periodontitis, exacerbated hypoxia-induced pulmonary hypertension in mice. Mechanistically, periodontitis dysregulated the pulmonary microbiota by promoting ectopic colonization and enrichment of oral bacteria in the lungs, contributing to pulmonary infiltration of interferon gamma positive (IFNγ+) T cells and aggravating the progression of pulmonary hypertension. In addition, we identified Prevotella zoogleoformans as the critical periodontitis-associated bacterium driving the exacerbation of pulmonary hypertension by periodontitis, and the exacerbation was potently ameliorated by both cervical lymph node excision and IFNγ neutralizing antibodies. Our study suggests a proof of concept that the combined prevention and treatment of periodontitis and pulmonary hypertension are necessary.

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Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease

Gao,

Yang,

Xiang

et al. 2024

Respir Res

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Little is known about the relationships between human genetics and the airway microbiome. Deeply sequenced airway metagenomics, by simultaneously characterizing the microbiome and host genetics, provide a unique opportunity to assess the microbiome-host genetic associations. Here we performed a co-profiling of microbiome and host genetics with the identification of over 5 million single nucleotide polymorphisms (SNPs) through deep metagenomic sequencing in sputum of 99 chronic obstructive pulmonary disease (COPD) and 36 healthy individuals. Host genetic variation was the most significant factor associated with the microbiome except for geography and disease status, with its top 5 principal components accounting for 12.11% of the microbiome variability. Within COPD individuals, 113 SNPs mapped to candidate genes reported as genetically associated with COPD exhibited associations with 29 microbial species and 48 functional modules (P < 1 × 10−5), where Streptococcus salivarius exhibits the strongest association to SNP rs6917641 in TBC1D32 (P = 9.54 × 10−8). Integration of concurrent host transcriptomic data identified correlations between the expression of host genes and their genetically-linked microbiome features, including NUDT1, MAD1L1 and Veillonella parvula, TTLL9 and Stenotrophomonas maltophilia, and LTA4H and Haemophilus influenzae. Mendelian randomization analyses revealed a potential causal link between PARK7 expression and microbial type III secretion system, and a genetically-mediated association between COPD and increased relative abundance of airway Streptococcus intermedius. These results suggest a previously underappreciated role of host genetics in shaping the airway microbiome and provide fresh hypotheses for genetic-based host-microbiome interactions in COPD.

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Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats

Cited by 3 publications

References 40 publications

Promising dawn in the management of pulmonary hypertension: The mystery veil of gut microbiota

Promising dawn in the management of pulmonary hypertension: The mystery veil of gut microbiota

Periodontitis exacerbates pulmonary hypertension by promoting IFNγ+ T cell infiltration in mice

Human genetic associations of the airway microbiome in chronic obstructive pulmonary disease

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