Airway Fistula Closure after Stem-Cell Infusion

Petrella, Francesco; Spaggiari, Lorenzo; Acocella, Fabio; Barberis, Massimo; Bellomi, Massimo; Brizzola, Stefano; Donghi, Stefano; Giardina, Giuseppina; Giordano, Rosaria; Guarize, Juliana; Lazzari, Lorenza; Montemurro, Tiziana; Pastano, Rocco; Rizzo, Stefania; Toffalorio, Francesca; Tosoni, Antonella; Zanotti, Marika

doi:10.1056/nejmc1411374

Cited by 52 publications

(38 citation statements)

References 3 publications

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“…A recent paper from Italy, showed the successful fistula closure after bronchoscopic transplantation of bone marrow-derived mesenchymal stem cells in the pars membranacea of the bronchus [28]. The degree of endoscopic success is variable and depends on the underlying disease and the proximity and size of the fistulas, with larger fistulas having poor closure rates [1].…”

Section: Commentmentioning

confidence: 99%

The Rationale for Treatment of Postresectional Bronchopleural Fistula: Analysis of 52 Patients

Cardillo

Carbone

Carleo

et al. 2015

The Annals of Thoracic Surgery

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Section: Commentmentioning

confidence: 99%

The Rationale for Treatment of Postresectional Bronchopleural Fistula: Analysis of 52 Patients

Cardillo

Carbone

Carleo

et al. 2015

The Annals of Thoracic Surgery

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“…A conservative or endoscopic approach may be attempted in case of small fistulas, but pleural debridement is mandatory in more complex cases to clean the pleural space and treat the occurring empyema. In addition, open window thoracostomy may be necessary to allow bronchial healing by means of continued pleural medications as well as by antibiotic irrigation and closure of the window (Clagett procedure) [22].…”

Section: Surgerymentioning

confidence: 99%

Therapeutic options following pneumonectomy in non-small cell lung cancer

Petrella

Spaggiari

2016

Expert Review of Respiratory Medicine

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Therapeutic options following pneumonectomy may be required at least in 3 different scenarios: 1) an early approach due to acute surgical complications 2) a late approach due to chronic surgical complications 3) an integrated radio-chemotherapeutic adjuvant approach for advanced stages. In this review we focused on these three settings with particular emphasis to surgical approach as well as to alternative options. Expert commentary: Pneumonectomy itself does not preclude postoperative additional treatments, if needed, to maximize oncological results and to manage potential short or long term complications. However, as pneumonectomy puts a significant physiological stress on the respiratory and circulatory systems, the benefits and risks of pneumonectomy should be compared with those of alternative, non-resectional treatment modalities.

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“…Secondly, a wide pericardial fat flap is mobilized to protect the stumps and the anastomosis and to separate the bronchial suture from the posterior aspect of the lining artery above. A pericardial fat flap was used not only because it is easy and fast to harvest, but mainly for its reparative properties due to the presence of adipose-derived stem cells (8).…”

Section: Discussionmentioning

confidence: 99%

Bronchial carcinoid in anomalous right upper bronchus: a “patient-tailored” bronchoplasty resection technique

et al. 2018

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Bronchial carcinoids (BC) are indolent neuroendocrine tumors (NET) that are classified as malignant because they can locally infiltrate and metastasize. Resection is the primary treatment for most localized carcinoid tumors, with lung parenchymal-sparing surgery the favoured objective for patients with central airway tumors. Sleeve bronchoplasty techniques are complex surgical procedures defined as parenchyma-saving because they allow a radical resection with tumor-free margins while preserving the maximum amount of parenchyma. They are mainly indicated for tumors arising at the origin of a lobar bronchus, precluding simple lobectomy but not infiltrating so far as to require pneumonectomy. We describe a case of typical bronchial carcinoid of an anomalous right upper bronchus requiring a "patient-tailored" bronchoplasty technique. The surgical aspects and preoperative work-up are discussed.

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Airway Fistula Closure after Stem-Cell Infusion

Cited by 52 publications

References 3 publications

The Rationale for Treatment of Postresectional Bronchopleural Fistula: Analysis of 52 Patients

The Rationale for Treatment of Postresectional Bronchopleural Fistula: Analysis of 52 Patients

Therapeutic options following pneumonectomy in non-small cell lung cancer

Bronchial carcinoid in anomalous right upper bronchus: a “patient-tailored” bronchoplasty resection technique

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