Airway hyperresponsiveness and chronic obstructive pulmonary disease outcomes

Cockcroft, Donald W.; Wenzel, Sally E.

doi:10.1016/j.jaci.2016.06.039

Cited by 6 publications

(6 citation statements)

References 13 publications

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“…Thus, persistent lung inflammation, associated with a progressive deterioration of respiratory function and infections in these patients, is an increasingly important clinical problem. Most of the clinical features and physiological abnormalities of mild‐to‐moderate COPD may be linked to AHR state (Cockcroft & Wenzel, ; Hospers, Postma, Rijcken, Weiss, & Schouten, ). Smokers with both asthma and COPD (Asthma‐COPD Overlap Syndrome, ACOS) recapitulate the above described clinical features and are exposed to an increased risk of disease progression and mortality (Tashkin et al, ; Vestbo et al, ) .…”

Section: Introductionmentioning

confidence: 99%

Functional contribution of sphingosine‐1‐phosphate to airway pathology in cigarette smoke‐exposed mice

Cunto

Brancaleone

Riemma

et al. 2019

British J Pharmacology

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Background and Purpose: A critical role for sphingosine kinase/sphingosine-1phosphate (S1P) pathway in the control of airway function has been demonstrated in respiratory diseases. Here, we address S1P contribution in a mouse model of mild chronic obstructive pulmonary disease (COPD).Experimental Approach: C57BL/6J mice have been exposed to room air or cigarette smoke up to 11 months and killed at different time points. Functional and molecular studies have been performed.Key Results: Cigarette smoke caused emphysematous changes throughout the lung parenchyma coupled to a progressive collagen deposition in both peribronchiolar and peribronchial areas. The high and low airways showed an increased reactivity to cholinergic stimulation and α-smooth muscle actin overexpression. Similarly, an increase in airway reactivity and lung resistances following S1P challenge occurred in smoking mice. A high expression of S1P, Sph-K 2 , and S1P receptors (S1P 2 and S1P 3 ) has been detected in the lung of smoking mice. Sphingosine kinases inhibition reversed the increased cholinergic response in airways of smoking mice.Conclusions and Implications: S1P signalling up-regulation follows the disease progression in smoking mice and is involved in the development of airway hyperresponsiveness. Our study defines a therapeutic potential for S1P inhibitors in management of airways hyperresponsiveness associated to emphysema in smokers with both asthma and COPD.

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Section: Introductionmentioning

confidence: 99%

Functional contribution of sphingosine‐1‐phosphate to airway pathology in cigarette smoke‐exposed mice

Cunto

Brancaleone

Riemma

et al. 2019

British J Pharmacology

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“…For an asthmatic patient with a long history of smoking or long-term exposure to air pollution, 17,18 combined with pulmonary CT scan revealing emphysema and low ventilation volume, 19 the diagnosis of ACOS is established. However, for a COPD patient, COPD may progress to ACOS if airway hyperresponsiveness 20,21 or airway remodeling and airway inflammation 22,23 are observed. Therefore, the definition of ACOS is still unclear in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

<p>Serum IL-8 and VEGFA are Two Promising Diagnostic Biomarkers of Asthma-COPD Overlap Syndrome</p>

Ding¹,

Sun²,

Zhang³

et al. 2020

COPD

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Background: Asthma-COPD overlap (ACO; previously referred to as asthma-COPD overlap syndrome) is characterized by persistent airflow limitation consistent with COPD, together with several distinguishing features of asthma. Asthma-COPD overlap syndrome is a condition of mixing symptoms of asthma and COPD, because of its complexity, it is difficult to find effective diagnostic markers in clinic. Purpose: Our aims were to detect the expression of serum cytokines in patients with asthma, explore the diagnostic potential of differential serum cytokines in ACOS. Patients and Methods: Ninety asthmatic patients were divided into ACOS group and non-ACOS group according to the major and minor criteria of ACOS, 15 kinds of cytokines including IL-3, IL-4, IL-8, IL-9, IL-13, IL-17A, VEGFA, VEGFC, VEGFD, bFGF, Fit-1 PIGF, Tie-2 were detected by MSD, and IL-27 and TGF-beta were determined by ELISA assay. Results: The serum levels of IL-9, VEGFA and PIGF in patients with ACOS were significantly higher than those in non-ACOS group (P<0.05, respectively), while the level of IL-8 and IL-17A in subjects with ACOS was lower than that in the non-ACOS group (P<0.05, respectively). We analyzed the correlation between several difference factors and FEV1/FVC% in the ACOS group, found VEGFA was negatively correlated with FEV1/FVC %, while IL-8 and IL-17A were positively correlated with FEV1/FVC%. Finally, three correlation factors were analyzed by ROC curve for the occurrence of ACOS. Conclusion: The results suggested that IL-8 was highly sensitive and VEGFA was highly specificity, both of which could be used as biomarkers for the diagnosis of ACOS.

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“…Measured with a challenge test and defined by a response beyond normal of the airways to nonspecific constrictor stimuli (4), airway hyper-responsiveness is a characteristic feature of asthma that is common among COPD patients too (5). Whether this feature precedes or is a consequence of COPD is unclear.…”

Section: How Do Smokers Quit?mentioning

confidence: 99%

Highlights from the European Respiratory Society 2017 annual congress: epidemiology and environment (assembly 6)

Gagnat

Amaral

2017

J. Thorac. Dis.

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Airway hyperresponsiveness and chronic obstructive pulmonary disease outcomes

Cited by 6 publications

References 13 publications

Functional contribution of sphingosine‐1‐phosphate to airway pathology in cigarette smoke‐exposed mice

Functional contribution of sphingosine‐1‐phosphate to airway pathology in cigarette smoke‐exposed mice

<p>Serum IL-8 and VEGFA are Two Promising Diagnostic Biomarkers of Asthma-COPD Overlap Syndrome</p>

Highlights from the European Respiratory Society 2017 annual congress: epidemiology and environment (assembly 6)

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