Airway imaging in disease: Gimmick or useful tool?

Paré, Peter D.; Nagano, Taishi

doi:10.1152/japplphysiol.00372.2012

Cited by 19 publications

(19 citation statements)

References 76 publications

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“…The inner and outer borders of the preterminal bronchioles were measured using the full width at half-maximum principle, which has been validated by histology in studies where airways approximately 2 mm in diameter and larger were examined (12,37). To compare airway WT measured by microCT with that measured by histology, we used the record of airway WT previously measured by histology in samples adjacent to those scanned with microCT (17).…”

Section: Discussionmentioning

confidence: 99%

Micro–Computed Tomography Comparison of Preterminal Bronchioles in Centrilobular and Panlobular Emphysema

Tanabe

Vasilescu

McDonough

et al. 2017

Am J Respir Crit Care Med

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Rationale: Very little is known about airways that are too small to be visible on thoracic multidetector computed tomography but larger than the terminal bronchioles.Objectives: To examine the structure of preterminal bronchioles located one generation proximal to terminal bronchioles in centrilobular and panlobular emphysema.Methods: Preterminal bronchioles were identified by backtracking from the terminal bronchioles, and their centerlines were established along the entire length of their lumens. Multiple cross-sectional images perpendicular to the centerline were reconstructed to evaluate the bronchiolar wall and lumen, and the alveolar attachments to the outer airway walls in relation to emphysematous destruction in 28 lung samples from six patients with centrilobular emphysema, 20 lung samples from seven patients with panlobular emphysema associated with alpha-1 antitrypsin deficiency, and 47 samples from seven control (donor) lungs. Measurements and Main Results:The preterminal bronchiolar length, wall volume, total volume (wall 1 lumen), lumen circularity, and number of alveolar attachments were reduced in both centrilobular and panlobular emphysema compared with control lungs. In contrast, thickening of the wall and narrowing of the lumen were more severe and heterogeneous in centrilobular than in panlobular emphysema. The bronchiolar lumen was narrower in the middle than at both ends, and the decreased number of alveolar attachments was associated with increased wall thickness in centrilobular emphysema.Conclusions: These results provide new information about small airways pathology in centrilobular and panlobular emphysema and show that these changes affect airways that are not visible with thoracic multidetector computed tomography scans but located proximal to the terminal bronchioles in chronic obstructive pulmonary disease.

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Section: Discussionmentioning

confidence: 99%

Micro–Computed Tomography Comparison of Preterminal Bronchioles in Centrilobular and Panlobular Emphysema

Tanabe

Vasilescu

McDonough

et al. 2017

Am J Respir Crit Care Med

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“…The clinical relevance of airway wall thickening in subjects without COPD is unclear to date, but as we showed that airway wall thickness is associated with FEV1, it may be clinically relevant in current and former smokers without COPD. Detecting and quantifying these structural changes by CT may become relevant in improving the prognosis of individual subjects [30].…”

Section: Discussionmentioning

confidence: 99%

Airway wall thickness associated with forced expiratory volume in 1 second decline and development of airflow limitation

et al. 2015

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Airway wall thickness and emphysema contribute to airflow limitation.We examined their association with lung function decline and development of airflow limitation in 2021 male smokers with and without airflow limitation. Airway wall thickness and emphysema were quantified on chest computed tomography and expressed as the square root of wall area of a 10-mm lumen perimeter (Pi10) and the 15th percentile method (Perc15), respectively. Baseline and follow-up (median (interquartile range) 3 (2.9-3.1) years) spirometry was available.Pi10 and Perc15 correlated with baseline forced expiratory volume in 1 s (FEV1) (r= −0.49 and 0.11, respectively ( p<0.001)). Multiple linear regression showed that Pi10 and Perc15 at baseline were associated with a lower FEV1 after follow-up ( p<0.05). For each SD increase in Pi10 and decrease in Perc15 the FEV1 decreased by 20 mL and 30.2 mL, respectively. The odds ratio for developing airflow limitation after 3 years was 2.45 for a 1-mm higher Pi10 and 1.46 for a 10-HU lower Perc15 ( p<0.001).A greater degree of airway wall thickness and emphysema was associated with a higher FEV1 decline and development of airflow limitation after 3 years of follow-up. @ERSpublications Computed tomography airway wall thickness and emphysema are associated with lung function decline and COPD http://ow.ly/DMN4h

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“…Preliminary work in severe asthma has shown improved 3 He gas distribution following localised bronchial thermoplasty treatment 32. While these results provide a strong foundation for the use of MRI in asthma research and patient care, a major drawback has been that we do not clearly understand the aetiology of MRI ventilation defects 33. It has been speculated that MRI ventilation defects reflect regional airway narrowing that may be the consequence of airway remodelling34; however, to our knowledge, the direct spatial and quantitative relationship between MRI ventilation defects and CT airway measurements has not been reported in patients with asthma.…”

Section: Introductionmentioning

confidence: 94%