Airway inflammation is augmented by obesity and fatty acids in asthma

Scott, Hayley A.; Gibson, Peter G.; Garg, Manohar L.; Wood, Lisa G.

doi:10.1183/09031936.00139810

Cited by 279 publications

(278 citation statements)

References 35 publications

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“…112,113 Obese asthmatic children did not have elevated airway LTB 4 . 134 Recent adult studies suggest that obesity may enhance neutrophilic airway inflammation 139 and systemic leukotriene production, 140 though this has not been evaluated in children. Since inhaled steroids are generally ineffective against neutrophilic inflammation, the discovery of neutrophilic inflammation in obese asthmatics is consistent with findings of reduced corticosteroids efficacy in the obese.…”

Section: Airway Inflammationmentioning

confidence: 99%

Obesity, Nutrition, and Asthma in Children

Lang

2012

Pediatric Allergy, Immunology, and Pulmonology

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Section: Airway Inflammationmentioning

confidence: 99%

Obesity, Nutrition, and Asthma in Children

Lang

2012

Pediatric Allergy, Immunology, and Pulmonology

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“…Obese and non-obese children and adults with asthma were recruited from the general community and John Hunter Hospital (Newcastle, Australia) [9,13]. In this study, we assayed stored samples of plasma from these two previously described populations.…”

Section: Subjectsmentioning

confidence: 99%

“…Furthermore, LANG et al [8] found age to be an important effect modifier of asthma control and airway function in obese asthma. Various studies have reported that obese adults with asthma had high levels of C-reactive protein (CRP) [9,10] and markers of macrophage infiltration [11]. Tryptase, a marker of mast cell activation, is also elevated in obese non-asthmatic adults [5].…”

Section: Introductionmentioning

confidence: 99%

Macrophage activation, age and sex effects of immunometabolism in obese asthma

et al. 2014

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Obese asthma is characterised by infiltration of adipose tissue by activated macrophages and mast cells. The aim of this study was to examine the age and sex effects of immunometabolism in obese asthma.Obese and non-obese asthmatic children and adults underwent spirometry, body composition assessment by dual energy X-ray absorptiometry and measurement of serum soluble CD163 (sCD163), tryptase, C-reactive protein (CRP) and other adipocytokines.Plasma CRP ( p<0.01) and leptin ( p<0.01) were elevated in obese asthmatic adults, and sCD163 ( p=0.003) was elevated in obese asthmatic children. We observed significantly higher sCD163 in obese female children compared to obese female adults and male children, and higher CRP in obese female adults compared to obese male children and adults. Serum tryptase concentrations were not significantly different across age groups. sCD163 positively correlated with the proportion of android fat in obese female children (r=0.70, p=0.003) and obese female adults (r=0.65, p=0.003). In obese female children, sCD163 was inversely associated with forced expiratory volume in 1 s % predicted (r=−0.55, p=0.02) and was positively associated with the Asthma Control Questionnaire (r=0.57, p=0.02).Obese children with asthma have sex-specific macrophage activation, which may contribute to worse asthma control and lung function. The heterogeneous systemic inflammatory profile across age and sex suggests the existence of sub-phenotypes in obese asthma at the molecular level. @ERSpublications Macrophage activation is a determinant of pro-inflammatory effects of immunometabolism in childhood obese asthma

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“…The etiology of the link between obesity and asthma is unknown, and proposed mechanisms include a proinflammatory effect of obesity and a physiological effect resulting from body composition changes associated with obesity (4,6). Additionally, there appear to be gender-specific differences in the mechanisms (7).…”

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confidence: 99%

Lean mass, not fat mass, is associated with lung function in male and female children with asthma

et al. 2013

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Background: Whether body composition is associated with lung function in asthmatic children has not been investigated. This study aimed to primarily investigate whether BMI z-score and body composition were associated with respiratory function in asthmatic children. Methods: In a cross-sectional study, male (n = 27; mean age: 11.9 y (SD: 2.3)) and female (n = 21; mean age: 13.6 y (SD: 2.2)) asthmatic children underwent clinical assessment. results: BMI z-score was associated with forced expiratory volume in 1 s (FEV 1 ; r = 0.458), forced vital capacity (FVC; r = 0.477), and total lung capacity (TLC; r = 0.451) in males only (P < 0.05). Total lean mass was associated with FEV 1 (r = 0.655), FVC (r = 0.562), and TLC (r = 0.635) in males, as was thoracic lean mass (FEV 1 (r = 0.573), FVC (r = 0.526), and TLC (r = 0.497); P < 0.05). TLC was associated with total (r = 0.522) and thoracic (r = 0.532) lean mass in females (P < 0.05). Fat mass was not associated with lung function in this group. conclusion: Lean mass, not fat mass, is associated with lung function in children with asthma. The positive association between BMI z-score and respiratory function in male children is driven by lean mass. Although body weight can be easily monitored in the clinical setting, body composition can provide important information. Future research exploring lean mass and lung function associations could inform future interventions.

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Airway inflammation is augmented by obesity and fatty acids in asthma

Cited by 279 publications

References 35 publications

Obesity, Nutrition, and Asthma in Children

Obesity, Nutrition, and Asthma in Children

Macrophage activation, age and sex effects of immunometabolism in obese asthma

Lean mass, not fat mass, is associated with lung function in male and female children with asthma

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