Airway involvement in interstitial lung disease

Cordeiro, Carlos Robalo

doi:10.1097/01.mcp.0000239550.47702.bd

Cited by 12 publications

(10 citation statements)

References 19 publications

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“…Acute fibrinous and organizing pneumonia (AFOP) is an unusual type of lung injury characterized by a typical histological pattern recently described whose main features are the presence of intra-alveolar fibrin in the form of “balls” and organizing pneumonia with patchy distribution, which does not meet the classic histologic criteria for bronchiolitis obliterans with organizing pneumonia (BOOP), eosinophilic pneumonia (EP), or diffuse alveolar damage (DAD) [1–3]. …”

Section: Introductionmentioning

confidence: 99%

“…Acute fibrinous and organizing pneumonia (AFOP) may be idiopathic in nature or associated with many factors, such as autoimmune rheumatic diseases, occupational exposure (exotic animals, coal and tungsten mines, and hairspray [1, 4]), altered immune status (long-term steroids use, poorly controlled diabetes, alcoholism, lymphoma, acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation, HIV infection, and Pneumocystis jiroveci pneumonia [1, 5, 6]), infectious causes ( Haemophilus influenzae , Acinetobacter baumannii, and coronavirus [1, 3]), and exposure to drugs (abacavir, decitabine, and amiodarone) [1, 7–9]. …”

Section: Introductionmentioning

confidence: 99%

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Acute Fibrinous and Organizing Pneumonia and Undifferentiated Connective Tissue Disease: A Case Report

Valim

Rocha

Couto

et al. 2012

Case Reports in Rheumatology

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Acute fibrinous and organizing pneumonia (AFOP), recently described, is a histologic pattern characterized by the presence of fibrin “balls” within alveolar spaces. The term undifferentiated connective tissue disease (UCTD) is used to identify autoimmune systemic diseases that do not fulfill the criteria to be classified as a definitive connective tissue disease. The AFOP has never been reported in association with UCTD. The present reported case is a 39-year-old Caucasian, female with dry cough and progressive dyspnea. Eight months later, she was diagnosed with “organizing pneumonia” based on clinical history and radiologic images. She manifested Raynaud's Phenomenon, sicca syndrome, boot and gloves neuropathic pain, and previous hypothyroidism. Antinuclear antibody, rheumatoid factor, and specific autoantibodies were negative. Salivary gland biopsy and electroneuromyiography were normal. The capillaroscopy showed a “scleroderma” pattern with capillary deletion and ectasia. She experienced clinical and radiologic worsening. Despite being submitted to cyclophosphamide pulse, she developed hemorrhage and then died. Thoracotomy pulmonary specimen showed histological pattern of AFOP. This paper shows a rare association of AFOP with UCTD.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acute Fibrinous and Organizing Pneumonia and Undifferentiated Connective Tissue Disease: A Case Report

Valim

Rocha

Couto

et al. 2012

Case Reports in Rheumatology

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“…Therefore, he concluded that BOOP should be considered when imaging reveals nodular lesions with an air bronchogram and irregular margins [7]. Thus, the first type of AFOP was reported to have some clinical similarities with BOOP [8-10]. Corticosteroid therapy resulted in the improvement of nodular lesions and diffuse infiltrates.…”

Section: Discussionmentioning

confidence: 99%

Acute Fibrinous and Organizing Pneumonia Following Hematopoietic Stem Cell Transplantation

Lee

Park

Sung

et al. 2009

Korean J Intern Med

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A 60-year-old man presented with cough, sputum, and dyspnea. He had a history of acute myeloid leukemia and hematopoietic stem cell transplantation with chronic renal failure. Chest CT scans showed miliary nodules and patchy consolidations. Histological examination revealed numerous fibrin balls within the alveoli and thickening of the alveolar septum, both of which are typical pathological features of acute fibrinous and organizing pneumonia (AFOP). We report the first case of AFOP following allogeneic hematopoietic stem cell transplantation.

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“…Review papers in 2006, 2007, and 2012 discussed clinicopathologic features of ILDs with airway involvement but provided no new cases of their own. [17][18][19] Imaging and pulmonary function test results for both case series and individual case report patients are shown in Table 3.…”

mentioning

confidence: 99%

Interstitial Lung Diseases That Are Difficult to Classify: A Review of Bronchiolocentric Interstitial Lung Disease

Virk

Fraire²

2015

Archives of Pathology &Amp; Laboratory Medicine

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Context Idiopathic bronchiolocentric interstitial pneumonia, airway-centered interstitial fibrosis, centrilobular fibrosis, and bronchiolitis interstitial pneumonia are increasingly recognized histopathologic variants of idiopathic interstitial pneumonia that are difficult to fit within existing classification schemes. Objective To review and analyze the appropriate literature that describes the spectrum of histopathologic changes in these conditions, in an effort to ascertain similarities as well as their differences. In addition, we examined associations with hypersensitivity, cigarette smoking, and survival data. Data Sources Relevant and peer-reviewed literature indexed in PubMed (National Library of Medicine) coupled with experience gained by review of personal cases with appropriate histopathology constitute the basis of this study. Conclusions As anticipated, the common link among the above-cited conditions is their bronchiolocentricity, with a predominance of either fibrosis or inflammation. Clear-cut associations with hypersensitivity or cigarette smoking are not evident in this study. The airway-centered interstitial fibrosis variant of bronchiolocentric interstitial lung disease appears to have a poor outcome.

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Airway involvement in interstitial lung disease

Cited by 12 publications

References 19 publications

Acute Fibrinous and Organizing Pneumonia and Undifferentiated Connective Tissue Disease: A Case Report

Acute Fibrinous and Organizing Pneumonia and Undifferentiated Connective Tissue Disease: A Case Report

Acute Fibrinous and Organizing Pneumonia Following Hematopoietic Stem Cell Transplantation

Interstitial Lung Diseases That Are Difficult to Classify: A Review of Bronchiolocentric Interstitial Lung Disease

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