Airway mucus, infection, and therapeutic strategies

NandyMazumdar, Monali

doi:10.1016/b978-0-323-85730-7.00056-4

Cited by 2 publications

(2 citation statements)

References 58 publications

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“…Glucocorticoids also function as potent anti-inflammatory agents, and a decrease in their expression can result in immunologic dysfunction, increased inflammation, and impaired immune system modulation [ 60 ]. MUC5AC is an inflammatory response-induced mucin protein, and its production has been reported to be suppressed by glucocorticoids [ 61 , 62 ]. In our study, the expression level of muc5ac was significantly up-regulated in the MMI and N100 groups.…”

Section: Discussionmentioning

confidence: 99%

Morphological and Transcriptomic Analyses Reveal the Toxicological Mechanism and Risk of Nitrate Exposure in Bufo gargarizans Embryos

Xie,

Niu,

Xiao

et al. 2024

Animals

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In recent years, nitrate (NO3-N) pollution in water bodies has been increasing due to the excessive use of nitrogen-based fertilizers. Exposure to NO3-N during the development of amphibian embryos may have lasting effects on the growth and development of individuals and even threaten their survival, but the toxicity mechanism of NO3-N in amphibian embryos prior to thyroid morphogenesis remains unclear. In the present study, Bufo gargarizans was selected as the model organism to investigate the toxic effects of 10 mg/L and 100 mg/L NO3-N exposure (N10 and N100) on amphibian embryos using methimazole (MMI) and exogenous thyroxine (T4) as the reference groups. We found that T4, MMI, N10 and N100 inhibited B. gargarizans embryo growth and development, with MMI and N100 showing the earliest and strongest effects. Transcriptome analysis revealed that MMI and NO3-N (especially N100) significantly downregulated genes related to thyroid morphogenesis and cholesterol metabolism, while upregulating genes related to inflammation and apoptosis. Together, these results contribute to a deeper understanding of the complex mechanisms by which NO3-N disrupts B. gargarizans embryonic development, reveal the potential risks of NO3-N pollution to other aquatic organisms, and provide insights into the conservation of a broader ecosystem.

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Section: Discussionmentioning

confidence: 99%

Morphological and Transcriptomic Analyses Reveal the Toxicological Mechanism and Risk of Nitrate Exposure in Bufo gargarizans Embryos

Xie,

Niu,

Xiao

et al. 2024

Animals

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“…However, most of these respiratory diseases such as cystic fibrosis (CF), lung cancer, bronchiectasis, and asthma are related to excessive mucus accumulation in the human respiratory system's tracheobronchial region, causing breathing obstruction but mostly for [3][4][5]. In most cases, mucus secreted by individuals with respiratory diseases has higher viscoelasticity compared to mucus from healthy individuals, causing mucus build-up in the airways and leading to the deterioration of lung function [6,7].…”

Section: Introductionmentioning

confidence: 99%

Examination of the behaviour of the lungs under high-frequency chest compression airway clearance therapy

Uzundurukan,

Poncet,

Boffito

et al. 2023

Progress in Canadian Mechanical Engineering. Volume 6

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Chronic Obstructive Pulmonary Disease (COPD) is the third leading cause of death worldwide, with 3 million in 2019. Medical devices for high-frequency chest compression (HFCC) therapy are currently the most common approach to relieve COPD symptoms in the lungs. The resonance frequency of the human thorax is one of the most influential parameters for HFCC to act on the viscoelastic, shearthinning, and thixotropic properties of bronchial mucus for airway clearance therapy (ACT). In this study, a 3D computed tomography-based finite element analysis (CT/FEA) is done by COMSOL Multiphysics ® 6.1 under the frequency domain with the purpose of examining the resonance frequency and the behaviour of lungs under HFCC therapy. An excitation under 140 dBSPL with a frequency range between 5 and 100 Hz is considered on the back-chest surface. As for comparison, the maximum kinetic energy density is 3.3 times higher than the kinetic energy density for the whole thorax because of the poroviscoelastic physical properties of the lungs. The lung kinetic energy density value reaches a peak at 56 µJ/m 3 at 30 Hz, which is supported by the numerical and experimental studies in the literature.

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Airway mucus, infection, and therapeutic strategies

Cited by 2 publications

References 58 publications

Morphological and Transcriptomic Analyses Reveal the Toxicological Mechanism and Risk of Nitrate Exposure in Bufo gargarizans Embryos

Morphological and Transcriptomic Analyses Reveal the Toxicological Mechanism and Risk of Nitrate Exposure in Bufo gargarizans Embryos

Examination of the behaviour of the lungs under high-frequency chest compression airway clearance therapy

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