Airway reactivity following repeated milk aspiration in rabbits

Colombo, John L.; Hallberg, Timothy K.

doi:10.1002/(sici)1099-0496(200002)29:2<113::aid-ppul5>3.0.co;2-g

Cited by 28 publications

(16 citation statements)

References 35 publications

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“…This suggests that GER and aspiration may contribute to the accumulation of lipids in alveolar macrophages. This is also consistent with the conclusion of COLOMBO and HALLBERG [18], who found only modest and not statistically significant elevation of LLI after microaspiration of milk in rabbits, which was explained by clearance of lipids from alveolar macrophages after aspiration. It is possible that food particles do not reach alveoli during microaspiration and are evacuated from the respiratory system due to ciliary and cough clearance.…”

Section: Discussionsupporting

confidence: 92%

Lipid-laden macrophage index and inflammation in bronchoalveolar lavage fluids in children

Kazachkov

Muhlebach²,

Livasy³

et al. 2001

European Respiratory Journal

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Section: Discussionsupporting

confidence: 92%

Lipid-laden macrophage index and inflammation in bronchoalveolar lavage fluids in children

Kazachkov

Muhlebach²,

Livasy³

et al. 2001

European Respiratory Journal

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“…Irritation of the vagus nerve due to GER increases the incidence of bronchospasm and hyper-responsiveness [20, 22]. An animal study has also demonstrated that GER and microaspiration are major risk factors in developing respiratory symptoms [23]. If the patients had been tested with the use of 24-h pH monitoring or gastric scintigraphy, our present study would have provided the mechanisms for the detrimental effects of bedtime bottle feeding on respiratory symptoms.…”

Section: Discussionmentioning

confidence: 97%

Prolonged bedtime bottle feeding and respiratory symptoms in infants

Kim

Han

Pyun

et al. 2011

Asia Pacific Allergy

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BackgroundInfants with chronic respiratory symptoms should be evaluated thoroughly because there are various causes which are different from those of children and adolescents.ObjectiveThis study was designed to investigate the relationship between chronic respiratory symptoms and bedtime bottle feeding in infants after the age of 6 months.MethodsWe conducted a prospective study that included 44 infants who presented with respiratory symptoms for more than 8 weeks and also had been bottle-fed during bedtime even after 6 months of age. The infants were divided into 2 groups; infants who discontinued bedtime bottle feeding and those who did not. Respiratory symptom scores were graded with a four-point scale at 0, 1, 2 and 3 months, and were compared between the 2 groups.ResultsTwenty eight infants (63.6%) stopped being bottle-fed during bedtime and 16 infants (36.4%) were still bottle-fed. The respiratory symptom scores were significantly decreased in infants who stopped bedtime bottle feeding (p = 0.0003).ConclusionIt is suggested that prolonged bedtime bottle feeding might be one of the causes of chronic respiratory symptoms in infants.

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“…In rabbits, weekly aspiration of a small volume of milk for 5 weeks is associated with an increased proportion of neutrophils in bronchoalveolar lavage and increased airway responsiveness to methacholine. 7 Gastroesophageal reflux (GER) and microaspiration of liquids in early childhood may result in chronic inflammation of the airways, recurrent bronchoconstriction, and, perhaps, airway remodeling. In addition, GER may cause reflex bronchospasm mediated by stimulation of vagal pathways in the esophagus.…”

Section: Discussionmentioning

confidence: 99%

Bottle Feeding in the Bed or Crib Before Sleep Time and Wheezing in Early Childhood

Celedón

Litonjua

Ryan³

et al. 2002

Pediatrics

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ABSTRACT.Objective. Bottle feeding in the bed or crib before sleep time has been associated with an increased risk of wheezing in the first year of life. We examined whether bottle feeding in the bed or crib before sleep time in the first year of life is associated with wheezing in the first 5 years of life.Methods. In a prospective cohort study of 448 children with parental history of atopy followed from birth, we examined the relation between the number of bimonthly parental reports of bottle feeding in the bed or crib before sleep time in the first year of life (range: 0 -6 reports) and parental report of wheezing in the first 5 years of life. Additional outcome measures included recurrent wheezing (>2 episodes of wheezing in the previous year) and asthma (physician-diagnosed asthma and >1 episode of wheezing in the previous year) at the age of 5 years.Results. The risk of recurrent wheezing and asthma at 5 years of age increased significantly with each additional report of bottle feeding in the bed or crib before sleep time in the first year of life. The risk of wheezing between the ages of 1 and 5 years increased with each additional report of bottle feeding in the bed or crib before sleep time in the first year of life. As an example, a child whose parents reported bottle feeding in the bed or crib before sleep time on 3 occasions in the first year of life had 1.5 times higher risk of wheezing between the ages of 1 and 5 years than a child whose parents did not report bottle feeding in the bed or crib before sleep time in the first year of life (95% confidence interval for relative risk: 1.12-2.12).Conclusions. Among children with parental history of atopy, bottle feeding in the bed or crib before sleep time in the first year of life is a risk factor for recurrent wheezing and asthma at 5 years of age and a risk factor for wheezing between the ages of 1 and 5 years. Pediatrics 2002;110(6). URL: http://www.pediatrics.org/ cgi/content/full/110/6/e77; bottle feeding, sleep time, wheezing.ABBREVIATIONS. IgE, immunoglobulin E; OR, odds ratio; CI, confidence interval; GER, gastroesophageal reflux. W heezing in early childhood is a common problem that may or may not be related to the subsequent development of asthma or allergies. 1,2 In most cases, wheezing that starts before the age of 3 years is transient and presumed to be related to viral infections in children with reduced airway caliber but not related to allergen sensitization or an elevated total serum immunoglobulin E (IgE) level at the age of 6 years. In a minority of infants, wheezing that starts before the age of 3 years persists up to the age of 6 years. Although children with persistent wheezing are more likely to have atopy and reduced lung function at the age of 6 years than nonwheezing children, persistent wheezing can occur in the absence of allergen sensitization. 1 Factors such as maternal smoking during pregnancy may influence the development of persistent wheezing through nonallergic mechanisms. 3 The Home Allergens and Asthma Study is a pro...

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Airway reactivity following repeated milk aspiration in rabbits

Cited by 28 publications

References 35 publications

Lipid-laden macrophage index and inflammation in bronchoalveolar lavage fluids in children

Lipid-laden macrophage index and inflammation in bronchoalveolar lavage fluids in children

Prolonged bedtime bottle feeding and respiratory symptoms in infants

Bottle Feeding in the Bed or Crib Before Sleep Time and Wheezing in Early Childhood

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