“…SS has a broad spectrum of craniofacial manifestations, that also include malar hypoplasia, a small jaw, high arched palate, a broad nasal bridge or micro/retrognathia, and a propensity for upper airway obstruction [2]. The prevalence of cleft palate in SS patients is estimated at approximately 40%, and 24% of patients are born with Pierre-Robin Sequence (small lower jaw, cleft palate, and tongue-bases obstruction) [2,3], a condition known to predispose patients to perioperative airway and respiratory complications [4]. Anesthetic management reports of SS patients are scarce but described complications include difficult facemask ventilation, oxygenation, and/or intubation, which may therefore represent an anticipated difficult airway (ADA) scenario.…”