Airway wall thickening on CT: Relation to smoking status and severity of COPD

Charbonnier, Jean-Paul; Pompe, Esther; Moore, Camille M.; Humphries, Stephen; Ginneken, Bram van; Make, Barry J.; Regan, Elizabeth A.; Crapo, James D.; Rikxoort, Eva M. van; Lynch, David A.

doi:10.1016/j.rmed.2018.11.014

Cited by 66 publications

(56 citation statements)

References 21 publications

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“…A study investigating whether the airwall thickening derived from CT is associated to diseases in smokers with or without COPD, showed that the Pi10, which was calculated from extracted airways and expressed as the square root of wall area of a hypothetical airway with internal perimeter of 10 mm, was increased in all GOLD stages and associated with worse FEV 1 predicted. Besides Pi10 was significantly higher in current smokers compared to former smokers and the average Pi10 of never smokers was significantly lower than both former and current smokers (45). In this study 2000 smokers and 46 never smokers group were from the COPD Gene study and were followed up for 5 years so they had repetitive CT scans.…”

Section: Imaging Modalitiesmentioning

confidence: 86%

The methods other than spirometry in the early diagnosis of COPD

Şerifoğlu¹,

Ulubay²

2019

Tuberk Toraks

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The methods other than spirometry in the early diagnosis of COPD Chronic obstructive pulmonary disease (COPD) is a major cause of mortality and morbidity around the world. The diagnosis od COPD is based on the presence of clinical symptoms and the fact that the ratio of post-bronhodilator forced expiratory volume in 1 second to forced expiratory vital capacity(FEV 1 / FVC) is less than 0.70. Persistent limitation of airflow which is a characteristics of COPD is reproducible and most common lung function test that is why it is usually measured by spirometry. The small airway diseases and the parenchymal destruction play a role in the pathogenesis of COPD at different rates over time resulting in chronic airflow limitation. These pathologies are not always together at the same time and the contribution of those to the development of COPD differ from one individual to another. The pathophysiological involvement of small airways in COPD has been confirmed. When the obstruction of the small airways occur either by mucus, smooth muscle hypertrophy, inflammatory infiltration or air wall thickening; then the consequence is the increased resistance and ventilation impairment. The parenchymal destruction can be estimated via scanning and at the initial assessment of a COPD patient, it gives information about the concomitant pulmonary diseases and/or differential diagnosis. There is an increasing interest on symptomatic individuals whose whose COPD diagnosis has not been confirmed yet with spirometry but diagnosis is based on alternative methods and approaches. Although these methods nowadays are commonly used for the clinical research, they will offer an opportunity to the clinician to find out the COPD patients at an early stage. Herein we will discuss the available methods other than spirometry in the early diagnosis of COPD before the overt disease is confirmed.

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Section: Imaging Modalitiesmentioning

confidence: 86%

The methods other than spirometry in the early diagnosis of COPD

Şerifoğlu¹,

Ulubay²

2019

Tuberk Toraks

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“…Given that airway parameters on chest CT have been regarded as radiological biomarkers for COPD and associated with air ow obstruction in all GOLD stages (35)(36)(37), airway structure and airway parameters on chest CT were obtained automatically to assess airway remodeling in our study. We demonstrated that the COPD group showed apparent changes in the airway structure, characterized by the thickened bronchial wall and rough and curved bronchial lumen.…”

Section: Discussionmentioning

confidence: 99%

Sestrin2 Was Involved in Airway Remodeling in COPD: A Multi-level Research

Zhang¹,

Wei²,

Ji³

et al. 2020

Preprint

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Background. Airway remodeling is a major pathological characteristic of chronic obstructive pulmonary disease (COPD), which is greatly associated with oxidative stress. Sestrin2 has recently drawn attention as a representative antioxidant protein. However, the underlying correlation between sestrin2 and airway remodeling in COPD has not yet been clarified.Methods. A total of 124 subjects were enrolled in this study, including 62 control subjects and 62 COPD patients. The pathological changes in airway tissues were showed by different staining methods. The expression of sestrin2 and matrix metalloproteinase 9 (MMP9) in airway tissues was assessed by Immunohistochemistry staining. Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum concentrations of sestrin2 and MMP9. The airway parameters on computed tomography (CT) of all participants were measured for the evaluation of airway remodeling. Serum sestrin2 concentrations' relationship with MMP9 and airway parameters on chest CT was further analyzed. Results. In patients with COPD, staining results of airway structure showed noticeable pathological changes of remodeling, including cilia cluttered, subepithelial fibrosis, and reticular basement membrane (Rbm) fragmentation. Compared with control subjects, the expression of sestrin2 and MMP9 was significantly increased in both human airway tissues and serum. Typical imaging characteristics of airway remodeling and increased airway parameters were found on chest CT. Additionally, the serum sestrin2 concentration was positively correlated with serum MMP9 concentration and airway parameters on chest CT.Conclusion. Increased expression of sestrin2 is related to airway remodeling in COPD at three levels including histology, biomarkers and imaging. It is demonstrated for the first time that sestrin2 may be a novel biomarker for airway remodeling in COPD.

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“…Emphysema score was calculated by calculating the percentage of lung voxels below −950 HU after resampling the CT images to 3 mm slice thickness, normalization, and bullae analysis ( Gevenois et al, 1996 ; Gallardo-Estrella et al, 2016 ). Pi10 is the square root of the airway wall area for a theoretical 10 mm lumen perimeter airway derived using the linear regression of the square root of segmented wall area against the lumen perimeter ( Charbonnier et al, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

Association between the number and size of intrapulmonary lymph nodes and chronic obstructive pulmonary disease severity

Schreuder

Jacobs

Scholten

et al. 2020

PeerJ

Self Cite

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Purpose One of the main pathophysiological mechanisms of chronic obstructive pulmonary disease is inflammation, which has been associated with lymphadenopathy. Intrapulmonary lymph nodes can be identified on CT as perifissural nodules (PFN). We investigated the association between the number and size of PFNs and measures of COPD severity. Materials and Methods CT images were obtained from COPDGene. 50 subjects were randomly selected per GOLD stage (0 to 4), GOLD-unclassified, and never-smoker groups and allocated to either “Healthy,” “Mild,” or “Moderate/severe” groups. 26/350 (7.4%) subjects had missing images and were excluded. Supported by computer-aided detection, a trained researcher prelocated non-calcified opacities larger than 3 mm in diameter. Included lung opacities were classified independently by two radiologists as either “PFN,” “not a PFN,” “calcified,” or “not a nodule”; disagreements were arbitrated by a third radiologist. Ordinal logistic regression was performed as the main statistical test. Results A total of 592 opacities were included in the observer study. A total of 163/592 classifications (27.5%) required arbitration. A total of 17/592 opacities (2.9%) were excluded from the analysis because they were not considered nodular, were calcified, or all three radiologists disagreed. A total of 366/575 accepted nodules (63.7%) were considered PFNs. A maximum of 10 PFNs were found in one image; 154/324 (47.5%) contained no PFNs. The number of PFNs per subject did not differ between COPD severity groups (p = 0.50). PFN short-axis diameter could significantly distinguish between the Mild and Moderate/severe groups, but not between the Healthy and Mild groups (p = 0.021). Conclusions There is no relationship between PFN count and COPD severity. There may be a weak trend of larger intrapulmonary lymph nodes among patients with more advanced stages of COPD.

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Airway wall thickening on CT: Relation to smoking status and severity of COPD

Cited by 66 publications

References 21 publications

The methods other than spirometry in the early diagnosis of COPD

The methods other than spirometry in the early diagnosis of COPD

Sestrin2 Was Involved in Airway Remodeling in COPD: A Multi-level Research

Association between the number and size of intrapulmonary lymph nodes and chronic obstructive pulmonary disease severity

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