AJCC Cancer Staging Manual

Amin, Mahul B.; Edge, Stephen B.; Greene, Frederick L.; Byrd, David R.; Brookland, Robert K.; Washington, Mary Kay; Gershenwald, Jeffrey E.; Compton, Carolyn C.; Hess, Kenneth R.; Sullivan, Daniel C.; Jessup, J. Milburn; Brierley, James D.; Gaspar, Lauri E.; Schilsky, Richard L.; Balch, Charles M.; Winchester, David P.; Asare, Elliot A.; Madera, Martin; Gress, Donna M.; Meyer, Laura

doi:10.1007/978-3-319-40618-3

Cited by 4,283 publications

(188 citation statements)

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“…The clinicopathological characteristics of the 113 HCC patients in association with CYP4F2 protein expression by immunohistochemical staining are presented in Table II (14,15). High CYP4F2 expression positively correlated with a favorable pathological TNM stage (stage I vs. stages II–IV) (P=0.022).…”

Section: Resultsmentioning

confidence: 99%

Profiling cytochrome P450 family 4 gene expression in human hepatocellular carcinoma

et al. 2018

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Cytochrome P450 family 4 (CYP4) enzymes are known as microsomal omega (ω)-hydroxylases that metabolize fatty acids, eicosanoids, vitamin D and carcinogens. Thus, CYP4 enzymes may influence tumor development and progression. The aim of the present study was to evaluate the CYP4 expression profile in hepatocellular carcinoma (HCC) and its clinical relevance. The present study obtained CYP4 mRNA expression data for 377 HCC cases from The Cancer Genome Atlas cohort and performed Kaplan-Meier survival, Gene Ontology functional enrichment, and gene set enrichment analysis (GSEA). In addition, the level of CYP4F2 protein expression was evaluated in matched pairs of HCC and non-tumor tissue samples and the results were correlated with the clinicopathological characteristics of HCC (n=113). HCC survival analyses indicated better overall survival in patients with high CYP4F2, CYP4F12 and CYP4V2 mRNA expression levels; the results for histological grade and Tumor-Node-Metastasis stage supported these results. GSEA revealed high levels of CYP4F2, CYP4F12 and CYP4V2 mRNA expression to be negatively correlated with the expression of cell cycle-associated genes. CYP4F2 protein expression was higher in non-neoplastic liver tissue than in HCC tissue and positively correlated with favorable pathological tumor stage (I vs. II–IV; P=0.022) and was a good independent prognostic factor for overall survival (P=0.004). These results demonstrate that the expression levels of the genes CYP4F2, CYP4F12 and CYPV2 are favorable prognostic factors in HCC and suggest the potential predictive diagnostic and prognostic roles of CYP4F2, CYP4F12 and CYPV2 gene expression in HCC.

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Section: Resultsmentioning

confidence: 99%

Profiling cytochrome P450 family 4 gene expression in human hepatocellular carcinoma

et al. 2018

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“…PCs are classified according to the WHO 2015 classification [6] and staged according to the 2017 revision of the Union Internationale Contre le Cancer/American Joint Committee on Cancer (UICC/AJCC) TNM classification [7]. In addition, the European Neuroendocrine Tumour Society (ENETS) [8] and North American Neuroendocrine Tumor Society (NANETS) [9] guidelines have provided recommendations for additional pieces of standardisation that encompass biochemical screening for hormonal syndrome, biomarker measurements, and imaging for staging, including functional imaging, genetic screening, and prognostic stratification (Table 1).…”

Section: Classification and Diagnosticsmentioning

confidence: 99%

Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms

et al. 2018

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Pulmonary carcinoids (PCs) display the common features of all well-differentiated neuroendocrine neoplasms (NEN) and are classified as low- and intermediate-grade malignant tumours (i.e., typical and atypical carcinoid, respectively). There is a paucity of randomised studies dedicated to advanced PCs and management principles are drawn from the larger gastroenteropancreatic NEN experience. There is growing evidence that NEN anatomic subgroups have different biology and different responses to treatment and, therefore, should be investigated as separate entities in clinical trials. In this review, we discuss the existing evidence and limitations of tumour classification, diagnostics and staging, prognostication, and treatment in the setting of PC, with focus on unmet medical needs and directions for the future.

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“…We retrospectively analyzed the clinicopathologic data of chemotherapeutically naïve patients with pathologically proven primary gastric cancer who underwent curative gastrectomy at the Second Hospital of Hebei Medical University (Shijiazhuang, China) between March 2007 and June 2016. Gastric cancer was staged using the American Joint Committee on Cancer stage criteria (AJCC, 8 th Edition) (23,24). We excluded patients with a history of prior gastric surgery or who had a family history of hereditary nonpolyposis colorectal cancer (HNPCC).…”

Section: Patientsmentioning

confidence: 99%

Gastric cancer is associated with a high rate of microsatellite instability versus chronic gastritis: A retrospective study

Guo

Zheng

et al. 2020

Revista Romana De Medicina De Laborator

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Objective: Microsatellite instability (MSI) in gastric cancer contributes to genetic complexities of gastric cancer. In the current study, we employed a panel of mononucleotide and dinucleotide markers to detect MSI in 99 gastric cancer patients and 91 chronic gastritis patients and further analyzed the association of MSI with clinicopathologic variables of the study patients. Methods: We retrospectively analyzed the clinicopathologic data of primary gastric cancer patients and chronic gastritis patients. MSI was analyzed using five microsatellite markers, including D2S12, D5S346, D17S799, BAT26, and D18S34. MSI was defined as either a band shift or the appearance of a novel band in DNA. Multivariate logistic regression analysis was used to predict risk of MSI. Results: Seventeen (17.2%) gastric cancer patients and 7 (7.7%) chronic gastritis patients were positive for MSI (P=0.012). Multivariate analysis further showed that gastric cancer was associated with a significantly higher likelihood for MSI versus gastritis (OR 3.73; 95% CI 1.19, 11.72; P=0.024) while age, drinking or smoking was not associated with increased MSI. Conclusion: Gastric cancer is associated with a high rate of MSI. MSI should be further explored in future studies with a larger sample size for its role in gastric cancer development and as a predictive biomarker.

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AJCC Cancer Staging Manual

Cited by 4,283 publications

References 0 publications

Profiling cytochrome P450 family 4 gene expression in human hepatocellular carcinoma

Profiling cytochrome P450 family 4 gene expression in human hepatocellular carcinoma

Unmet Medical Needs in Pulmonary Neuroendocrine (Carcinoid) Neoplasms

Gastric cancer is associated with a high rate of microsatellite instability versus chronic gastritis: A retrospective study

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