This paper deals with Geographical Indications (GI) as a critical strategy aimed to boost agri-food local supply chain and rural development. The main concern of this work, therefore, is to verify how the identification of these products and establishment of GI systems can propel sustainable development in local areas in Africa. Two assumptions are at the basis of our paper: viable GI systems can be established in Africa, and the establishment of a GI system can stimulate rural development. In order to clarify the process of GI setting up and valorization, we will test GI virtuous circle and the rural web, with the purpose of exploring the multiple dimensions (endogeneity, social capital, sustainability, novelty, institutional arrangements, governance of markets) interfering in the process at both the agri-food supply chain and rural context levels of analysis. The analysis is applied to the shea butter production in Ghana and will employ primary data. Questionnaires and interviews were administered in the study area (Yendi Municipality of Ghana) to gather both qualitative and quantitative data. Our analysis confirms the potentialities of the shea butter as GI, by underlying its engine for the development of local rural communities.