AKIR-1 regulates proteasome subcellular function in Caenorhabditis elegans

Pispa, Johanna; Mikkonen, Elisa; Arpalahti, Leena; Jin, Congyu; Martínez-Fernández, Carmen; Cerón, Julián; Holmberg, Carina I.

doi:10.1016/j.isci.2023.107886

Cited by 1 publication

(1 citation statement)

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“…HBXIP affects the malignant progression of tumor cells by altering the acetylation or ubiquitination of target proteins through several mechanisms, thereby regulating their intracellular abundance and activity ( Table II ). The ubiquitination-proteasome pathway is one of the major pathways of protein degradation ( 55 ). HBXIP can prevent this pathway in three ways: i) The first mechanism is though the activation of acetylases.…”

Section: Hbxip and Tumorsmentioning

confidence: 99%

Research progress on oncoprotein hepatitis B X‑interacting protein (Review)

Cheng,

Guo,

Zou

et al. 2024

Mol Med Rep

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Hepatitis B X-interacting protein (HBXIP) is a membrane protein located on the lysosomal surface and encoded by the Lamtor gene. It is expressed by a wide range of tumor types, including breast cancer, esophageal squamous cell carcinoma and hepatocellular carcinoma, and its expression is associated with certain clinicopathological characteristics. In the past decade, research on the oncogenic mechanisms of HBXIP has increased and the function of HBXIP in normal cells has been gradually elucidated. In the present review, the following was discussed: The normal physiological role of the HBXIP carcinogenic mechanism; the clinical significance of high levels of HBXIP expression in different tumors; HBXIP regulation of transcription, post-transcription and post-translation processes in tumors; the role of HBXIP in improving the antioxidant capacity of tumor cells; the inhibition of ferroptosis of tumor cells and regulating the metabolic reprogramming of tumor cells; and the role of HBXIP in promoting the malignant progression of tumors. In conclusion, the present review summarized the existing knowledge of HBXIP, established its carcinogenic mechanism and discussed future related research on HBXIP.

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Section: Hbxip and Tumorsmentioning

confidence: 99%