Akkermansia muciniphila: A potential novel mechanism of nuciferine to improve hyperlipidemia

Yu, Yue; Liu, Juan; Sun, Li‐Zhong; Lyu, Xinkai; Chang, Xinyue; Mi, Xiao; Hu, Meigeng; Wu, Chongming; Chen, Xi

doi:10.1016/j.biopha.2020.111014

Cited by 56 publications

(29 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mucispirillum, Akkermansia and Butyricimonas, Faecalibaculum rodentium, and OTUs belonging to the family of Bacteroidacea, Erysipelotrichaceae and Streptococcaceae, have potentially beneficial interactions with energy regulation and metabolism. [65][66][67][68] Notably, the observed beneficial effects of WEFL on HFD-induced obesity and liver injury were significantly suppressed after removal of the gut microbiota, demon-…”

Section: Discussionmentioning

confidence: 99%

Water extract ofFerula lehmanni Boiss.prevents high-fat diet-induced overweight and liver injury by modulating the intestinal microbiota in mice

Shi

Wang

et al. 2022

Food Funct.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Water extract ofFerula lehmanni Boiss.prevents high-fat diet-induced overweight and liver injury by modulating the intestinal microbiota in mice

Shi

Wang

et al. 2022

Food Funct.

View full text Add to dashboard Cite

show abstract

“…There are two main reasons: food consumption and certain bacteria that have penetrated the intestinal barrier cannot be detected precisely, such as Akkermansia. Akkermansia plays a critical role in maintaining human immunity and metabolism, can strengthen the intestinal barrier by promoting mucus secretion ( van der Lugt et al, 2019 ), thus it has been deemed a promising therapeutic probiotic ( Zou and Chen, 2020 ; Yu et al, 2021 ). Hence, we selected mucosal specimens instead of feces in this study.…”

Section: Discussionmentioning

confidence: 99%

Albuca Bracteata Polysaccharides Attenuate AOM/DSS Induced Colon Tumorigenesis via Regulating Oxidative Stress, Inflammation and Gut Microbiota in Mice

Qin

Liu

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Inflammation is an important risk factor in the development of inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC). Accumulating evidence indicates that some phytochemicals have anti-cancer properties. Polysaccharides extracted from Albuca bracteata (AB) have been reported to possess anti-neoplastic activities on colorectal cancer (CRC) models. However, it is still unclear whether they exert therapeutic effects on colorectal cancer. In this study, we investigate the properties of polysaccharides of A. bracteate, named ABP. The average molecular weight of ABP was 18.3 kDa and ABP consisted of glucose, mannose, galactose, xylose, galacturonic acid, glucuronic acid at a molar ratio of 37.8:8:2.5:1.7:1:1. An Azoxymethane/Dextran sodium sulfate (AOM/DSS) induced CAC mouse model was established. The CAC mice treated with ABP showed smaller tumor size and lower tumor incidence than untreated ones. ABP increased anti-inflammatory cytokine IL-10, inhibited secretion of pro-inflammatory cytokines (IL-6, IFN-γ, and TNF-α), mitigated oxidative stress by increasing GSH and decreasing MDA levels, suppressed the activation of STAT3 and expressions of its related genes c-Myc and cyclin D1. Moreover, ABP treatment increased the relative abundance of beneficial bacteria (f_Ruminococcaceae, g_Roseburia, g_Odoribacter, g_Oscillospira, and g_Akkermansia) and the levels of fecal short-chain fatty acid (SCFA) in CAC model mice. In summary, our data suggest that ABP could be a potential therapeutic agent for treating CAC.

show abstract

“…However, few studies have demonstrated the role of Faecalibaculum or Roseburia in NAFLD, and further study is required before conclusions on their importance can be drawn. Furthermore, accumulated studies have demonstrated that compounds and herbs such as curcumin [ 38 ], Astragalus membranaceus polysaccharide [ 39 ], nuciferine [ 40 ], and Radix Paeoniae Rubra [ 41 ] in JGXZ could regulate gut microbiota. Further studies could be carried out to identify the critical compounds of JGXZ with regulatory effects on gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

Jian-Gan-Xiao-Zhi Decoction Alleviates Inflammatory Response in Nonalcoholic Fatty Liver Disease Model Rats through Modulating Gut Microbiota

Liao

Xie

Gao

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Jian-Gan-Xiao-Zhi decoction (JGXZ), composed of Salvia miltiorrhiza Bunge, Panax notoginseng, Curcuma zedoaria, and other 9 types of herbs, has demonstrated beneficial effects on nonalcoholic fatty liver disease (NAFLD). However, the mechanisms behind JGXZ’s impact on NAFLD remain unknown. Methods. In this study, a NAFLD rat model induced by a high-fat diet (HFD) received oral treatment of JGXZ (8 or 16 g crude herb/kg) for 12 weeks. The therapeutic effects of JGXZ on NAFLD model rats were investigated through blood lipid levels and pathological liver changes. 16S rRNA analysis was used to study the changes in gut microbiota after JGXZ treatment. The expressions of occludin and tight junction protein 1 (ZO-1) in the colon were investigated using immunostaining to study the effects of JGXZ on gut permeability. The anti-inflammatory effects of JGXZ were also studied through measuring the levels of IL-1β, IL-6, and TNF-α in the serum and liver. Results. JGXZ treatment could decrease body weight and ameliorate dyslipidemia in NAFLD model rats. H&E and Oil Red O staining indicated that JGXZ reduced steatosis and infiltration of inflammatory cells in the liver. 16S rRNA analysis showed that JGXZ impacted the diversity of gut microbiota, decreasing the Firmicutes–to-Bacteroidetes ratio, and increasing the relative abundance of probiotics, such as Alloprevotella, Lactobacillus, and Turicibacter. Gut permeability evaluation found that the expressions of ZO-1 and occludin in the colon were increased after JGXZ treatment. Moreover, JGXZ treatment could decrease the levels of IL-1β, IL-6, and TNF-α in the serum and liver. Conclusions. Our study illustrated that JGXZ could ameliorate NAFLD through modulating gut microbiota, decreasing gut permeability, and alleviating inflammatory response.

show abstract

Akkermansia muciniphila: A potential novel mechanism of nuciferine to improve hyperlipidemia

Cited by 56 publications

References 21 publications

Water extract ofFerula lehmanni Boiss.prevents high-fat diet-induced overweight and liver injury by modulating the intestinal microbiota in mice

Water extract ofFerula lehmanni Boiss.prevents high-fat diet-induced overweight and liver injury by modulating the intestinal microbiota in mice

Albuca Bracteata Polysaccharides Attenuate AOM/DSS Induced Colon Tumorigenesis via Regulating Oxidative Stress, Inflammation and Gut Microbiota in Mice

Jian-Gan-Xiao-Zhi Decoction Alleviates Inflammatory Response in Nonalcoholic Fatty Liver Disease Model Rats through Modulating Gut Microbiota

Contact Info

Product

Resources

About