Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism

Xia, Jiafeng; Lv, Longxian; Liu, Boqiang; Wang, Zhen; Zhang, Sitong; Wu, Zhengjie; Yang, Liya; Bian, Xiaoyuan; Wang, Qiangqiang; Wang, Kaicen; Zhuge, Aoxiang; Li, Shengjie; Ren, Yan; Jiang, Huiyong; Xu, Kaijin; Li, Lanjuan

doi:10.1128/spectrum.01596-21

Cited by 88 publications

(90 citation statements)

References 70 publications

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“…The function of Christensenellaceae_R_7_group is the same as that of Christensenellaceae ( Morotomi et al, 2012 ). Additionally, Candidatus_Saccharimonas species are positively correlated with propionic acid and butyric acid levels ( Xia et al, 2022 ) and play an important role in maintaining gut functions ( Xie et al, 2021 ). The relative abundance of the genus Akkermansia was greater in the FH group than in the other groups.…”

Section: Discussionmentioning

confidence: 99%

High-Altitude Drives the Convergent Evolution of Alpha Diversity and Indicator Microbiota in the Gut Microbiomes of Ungulates

Wang

Shang

et al. 2022

Front. Microbiol.

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Convergent evolution is an important sector of evolutionary biology. High-altitude environments are one of the extreme environments for animals, especially in the Qinghai Tibet Plateau, driving the inquiry of whether, under broader phylogeny, high-altitude factors drive the convergent evolution of Artiodactyla and Perissodactyla gut microbiomes. Therefore, we profiled the gut microbiome of Artiodactyla and Perissodactyla at high and low altitudes using 16S rRNA gene sequencing. According to cluster analyses, the gut microbiome compositions of high-altitude Artiodactyla and Perissodactyla were not grouped together and were far from those of low-altitude Artiodactyla and Perissodactyla. The Wilcoxon’s test in high-altitude ungulates showed significantly higher Sobs and Shannon indices than in low-altitude ungulates. At the phylum level, Firmicutes and Patescibacteria were significantly enriched in the gut microbiomes of high-altitude ungulates, which also displayed a higher Firmicutes/Bacteroidetes value than low-altitude ungulates. At the family level, Ruminococcaceae, Christensenellaceae, and Saccharimonadaceae were significantly enriched in the gut microbiomes of high-altitude ungulates. Our results also indicated that the OH and FH groups shared two significantly enriched genera, Christensenellaceae_R_7_group and Candidatus_Saccharimonas. These findings indicated that a high altitude cannot surpass the order level to drive the convergent evolution of ungulate gut microbiome composition but can drive the convergent evolution of alpha diversity and indicator microbiota in the gut microbiome of ungulates. Overall, this study provides a novel perspective for understanding the adaptation of ungulates to high-altitude environments.

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Section: Discussionmentioning

confidence: 99%

High-Altitude Drives the Convergent Evolution of Alpha Diversity and Indicator Microbiota in the Gut Microbiomes of Ungulates

Wang

Shang

et al. 2022

Front. Microbiol.

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“…Oral Lactobacillus rhamnosus GG has been shown to protect against APAP-induced liver injury by activating Nrf2 via Lactobacillus-derived 5-methoxyindoleacetic acid [41]. Recent reports have shown that oral administration of Akkermansia muciniphila improved oxidative stress and inflammation to protect against APAP-induced liver injury, which was closely related to the remodeling of intestinal microflora and enhanced short-chain fatty acids (SCFAs) [42]. In this study, the hepatoprotective effect of BPP disappeared after depleting the intestinal flora.…”

Section: Discussionmentioning

confidence: 99%

Broussonetia papyrifera Polysaccharide Alleviated Acetaminophen-Induced Liver Injury by Regulating the Intestinal Flora

Hao

Chen

et al. 2022

Nutrients

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Liver injury caused by an overdose of acetaminophen (APAP) is a major public health problem. This study aimed to evaluate the effects of Broussonetia papyrifera polysaccharide (BPP) on liver injury and intestinal flora induced by APAP. The results showed that BPP could protect against APAP-induced liver injury, alleviate liver apoptosis, improve antioxidant capacity and enhance the liver’s detoxification ability to APAP. At the same time, BPP improved the intestinal flora disorder caused by APAP. More importantly, we found that the hepatoprotective effect of BPP disappeared after the depletion of gut microbiota in mice. Further, we reconstructed the intestinal flora structure of mice through fecal microbiota transplantation and found that the symptoms of APAP—induced liver injury were effectively alleviated. Overall, BPP was a potential hepatoprotective drug that could protect against APAP-induced liver injury and might be mediated by intestinal flora.

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“…The hepatoprotective roles of probiotics and their protective mechanism against APAP hepatotoxicity have been revealed in different preclinical studies [ 78 , 79 , 80 , 81 ]. In these reports, different probiotic strains exhibited different mechanisms of hepatoprotection against APAP hepatotoxicity.…”

Section: Protective Roles Of Probiotic Strains Against Apap Hepatotox...mentioning

confidence: 99%

“…In addition to their inherent mechanisms, such as reconditioning gut microbiota, maintaining a healthy gut barrier, improving ATP production, and preventing negative metabolic effects, probiotics also ensured antioxidant, immunomodulatory, and anti-inflammatory mechanisms to counteract APAP hepatotoxicity. Moreover, probiotics have been shown to regulate various signaling events against APAP hepatotoxicity [ 73 , 81 ]. A few reports showed that a few probiotic strains can interfere with the pharmacokinetics of APAP [ 75 ].…”

Section: Protective Roles Of Probiotic Strains Against Apap Hepatotox...mentioning

confidence: 99%

“…A few reports showed that a few probiotic strains can interfere with the pharmacokinetics of APAP [ 75 ]. In addition, probiotics use prebiotics to produce some metabolic products, such as short-chain fatty acids, that can attenuate APAP hepatotoxicity [ 81 ]. A schematic overview of the overall hepatoprotective mechanism of probiotics against APAP hepatotoxicity is depicted in Figure 2 .…”

Section: Protective Roles Of Probiotic Strains Against Apap Hepatotox...mentioning

confidence: 99%

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Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity

et al. 2022

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Acetaminophen (APAP) is the most common prescription medicine around the world for the treatment of pain and fever and is considered to be a safe drug at its therapeutic dose. However, a single overdose or frequent use of APAP can cause severe acute liver injury. APAP hepatotoxicity is a prevalent cause of acute liver disease around the world and the lack of suitable treatment makes it a serious problem. In recent years, there has been a surge in interest in using probiotics and probiotic-derived products, known as postbiotics, as health and disease negotiators. A growing body of evidence revealed that they can be equally effective against APAP hepatotoxicity. Different probiotic bacteria were found to be pre-clinically effective against APAP hepatotoxicity. Different postbiotics have also shown exciting results in preclinical models of APAP hepatotoxicity. This review summarized the protective roles and mechanisms of the different probiotic bacteria and postbiotics against APAP hepatotoxicity, with critical discussion. A brief discussion on potential novel probiotics and postbiotics for oxidative liver injury was also included. This review was written in an attempt to pique the interest of researchers in developing a safe therapeutic option against oxidative liver damage using probiotics and/or postbiotics as dietary supplements.

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Akkermansia muciniphila Ameliorates Acetaminophen-Induced Liver Injury by Regulating Gut Microbial Composition and Metabolism

Cited by 88 publications

References 70 publications

High-Altitude Drives the Convergent Evolution of Alpha Diversity and Indicator Microbiota in the Gut Microbiomes of Ungulates

High-Altitude Drives the Convergent Evolution of Alpha Diversity and Indicator Microbiota in the Gut Microbiomes of Ungulates

Broussonetia papyrifera Polysaccharide Alleviated Acetaminophen-Induced Liver Injury by Regulating the Intestinal Flora

Probiotics: Evolving as a Potential Therapeutic Option against Acetaminophen-Induced Hepatotoxicity

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