2020
DOI: 10.3390/microorganisms8091360
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Akkermansia muciniphila is Negatively Correlated with Hemoglobin A1c in Refractory Diabetes

Abstract: Patients with refractory diabetes are defined as type 2 diabetes (T2D) patients; they cannot achieve optimal glycemic control and exhibit persistent elevations of hemoglobin A1c (HbA1c) ≥8% while on appropriate therapy. Hyperglycemia can lead to severe microvascular/macrovascular complications. However, in contrast to T2D, few studies have focused specifically on the gut microbiota in refractory diabetes. To examine this issue, we recruited 79 subjects with T2D and refractory diabetes (RT2D), and all subjects … Show more

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Cited by 36 publications
(29 citation statements)
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“… 35 In addition, in previous studies on refractory diabetes and autism spectrum disorders, it was known that the abundances of B. vulgatus and A. muciniphila are inversely proportional. 36 37 This inverse relationship between these two species was also confirmed in the present study, suggesting that the relationship between the two species provides insights on the pathophysiology of EEN.…”
Section: Discussionsupporting
confidence: 88%
“… 35 In addition, in previous studies on refractory diabetes and autism spectrum disorders, it was known that the abundances of B. vulgatus and A. muciniphila are inversely proportional. 36 37 This inverse relationship between these two species was also confirmed in the present study, suggesting that the relationship between the two species provides insights on the pathophysiology of EEN.…”
Section: Discussionsupporting
confidence: 88%
“…Raw paired-end reads were also analyzed using the BaseSpace Ribosomal Database Project (RDP) classifier. OTUs (relative abundance), α-diversity (Shannon entropy and Venn diagram), and β-diversity (PCoA-D_0.5 UniFrac) were determined using BaseSpace (Illumina, San Diego, CA, USA), CLC Genomics Workbench 21 with Microbial Genomics Module (Qiagen, Germantown, MD, USA) and GraphPad Prism 8 (GraphPad Software, La Jolla, CA, USA) 19 .…”
Section: Methodsmentioning
confidence: 99%
“…Correlations were calculated using the Pearson correlation coefficient. All statistical analyses were performed using GraphPad Prism 8 (GraphPad Software, La Jolla, CA, USA) 19 .…”
Section: Methodsmentioning
confidence: 99%
“…Evidence also suggests that Akkermansia prefers to ingest carbohydrates (mainly polysaccharides) as its nutritional source [34]. A. muciniphila has the ability to improve diabetes, reducing body fat production, and suppressing weight gain; therefore, increasing A. muciniphila in the intestines through diet is believed to have the ability to improve metabolic syndrome [49,50]. As shown in Figure 10A, the relative abundances of Akkermansia spp.…”
Section: The Regulation Of C Militaris On Gut Microbiota In Hfsd-induced Micementioning
confidence: 99%